{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:18:08Z","timestamp":1785251888239,"version":"3.55.0"},"reference-count":40,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Government of the Russian Federation","award":["15.34.3.2017"],"award-info":[{"award-number":["15.34.3.2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>There is a need to further characterize the antibody response to vimentin in relation to its possible involvement in pathogenicity of sarcoidosis and other lung disorders. Objectives: We investigated serum samples from patients with sarcoidosis, healthy controls and controls with other non-infectious lung diseases., to evaluate levels and frequency of these antibodies. Materials and methods: A retrospective-prospective comparative study was performed in the years 2015\u20132019. Sera from 93 patients with sarcoidosis, 55 patients with non-infectious lung diseases and 40 healthy subjects was examined for presence of autoantibodies to mutated citrullinated vimentin (anti-MCV). Patients with elevated anti-MCV levels were tested for antibodies to a cyclic citrullinated peptide (anti-CCP) and citrullinated vimentin (anti-Sa). In all cases ELISA assays was used. The results were considered statistically significant at p-value less than 0.05. Results of the study: The high concentrations of anti-MCV antibodies were more frequent in patients with sarcoidosis (40.9% of the cases, 38\/93), compared to the control groups (23.6% and 25.0% of cases, respectively). In sarcoidosis, clinical symptoms similar to the autoimmune pathology were described. A moderate positive correlation between the anti-MCV and anti-Sa antibodies (r = 0.66) was found in 13 patients with sarcoidosis. There was no significant difference between the levels of the anti-MCV and the anti-CCP in patients with non-infectious lung diseases and the healthy control group. Conclusion: Antibodies to citrullinated cyclic peptides are not significant in the pathogenesis of sarcoidosis and other investigated pulmonary diseases (COPD, granulomatosis with polyangiitis, alveolitis) and based on their low concentration, it can be assumed that citrullination and modification of vimentin is not a key factor in the development of an autoimmune response in patients with sarcoidosis.<\/jats:p>","DOI":"10.3390\/diagnostics12081939","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T05:43:57Z","timestamp":1660196637000},"page":"1939","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Detection of Anti-Vimentin Antibodies in Patients with Sarcoidosis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-6986","authenticated-orcid":false,"given":"Anna","family":"Starshinova","sequence":"first","affiliation":[{"name":"Laboratory of the Mosaic of Autoimmunity, Medical Department, St. Petersburg State University, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6008-1354","authenticated-orcid":false,"given":"Anna","family":"Malkova","sequence":"additional","affiliation":[{"name":"Laboratory of the Mosaic of Autoimmunity, Medical Department, St. Petersburg State University, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6273-4304","authenticated-orcid":false,"given":"Ulia","family":"Zinchenko","sequence":"additional","affiliation":[{"name":"Laboratory of the Mosaic of Autoimmunity, Medical Department, St. Petersburg State University, 199034 St. Petersburg, Russia"},{"name":"Phthisiopulmonology Department, St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, 127994 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4998-3699","authenticated-orcid":false,"given":"Sergey","family":"Lapin","sequence":"additional","affiliation":[{"name":"Laboratory for the Diagnosis of Autoimmune Diseases of the Scientific and Methodological Center, St. Petersburg State Medical University, 194100 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3055-6507","authenticated-orcid":false,"given":"Alexandra","family":"Mazing","sequence":"additional","affiliation":[{"name":"Laboratory for the Diagnosis of Autoimmune Diseases of the Scientific and Methodological Center, St. Petersburg State Medical University, 194100 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1878-4467","authenticated-orcid":false,"given":"Dmitry","family":"Kudlay","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia"},{"name":"Laboratory of Personalized Medicine and Molecular Immunology, NRC Institute of Immunology FMBA of Russia, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Yablonskiy","sequence":"additional","affiliation":[{"name":"Laboratory of the Mosaic of Autoimmunity, Medical Department, St. Petersburg State University, 199034 St. Petersburg, Russia"},{"name":"Phthisiopulmonology Department, St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, 127994 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[{"name":"Laboratory of the Mosaic of Autoimmunity, Medical Department, St. Petersburg State University, 199034 St. Petersburg, Russia"},{"name":"Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.chest.2017.11.030","article-title":"The pathogenesis of pulmonary sarcoidosis and implications for treatment","volume":"153","author":"Patterson","year":"2018","journal-title":"Chest"},{"key":"ref_2","first-page":"197","article-title":"Sarcoidosis and autoimmunity: From Genetic background to environmental factors","volume":"18","author":"Bindoli","year":"2016","journal-title":"Isr. 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