{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:33:26Z","timestamp":1774528406325,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The assessment of fibrosis in chronic liver diseases using non-invasive methods is an important topic in hepatology. The aim of this study is to identify patients with non-alcoholic fatty liver disease (NAFLD) and advanced liver fibrosis by establishing correlations between biological\/ultrasound markers and non-invasively measured liver stiffness. This study enrolled 116 patients with non-alcoholic fatty liver disease, which were evaluated clinically, biologically, and by ultrasound. Liver fibrosis was quantified by measuring liver stiffness by shear wave elastography (SWE). Multiple correlation analysis of predictors of liver fibrosis identified a number of clinical, biological, and ultrasound parameters (BMI, blood glucose, albumin, platelet count, portal vein diameter, bipolar spleen diameter) that are associated with advanced liver fibrosis in patients with non-alcoholic fatty liver disease. The correlations between the degree of liver fibrosis and the risk values of some serological and ultrasound markers obtained in our study could be useful in clinical practice for the identification of advanced fibrosis in patients with NAFLD.<\/jats:p>","DOI":"10.3390\/diagnostics12092136","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T23:35:57Z","timestamp":1662420957000},"page":"2136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk Predictors of Advanced Fibrosis in Non-Alcoholic Fatty Liver Disease"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3204-0878","authenticated-orcid":false,"given":"Vasile-Andrei","family":"Olteanu","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Gr. T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, St. 1 Spiridon Emergency County Hospital, 1, Independentei Boulevard, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gheorghe G.","family":"Balan","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Gr. T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, St. 1 Spiridon Emergency County Hospital, 1, Independentei Boulevard, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana","family":"Timofte","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Gr. T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, St. 1 Spiridon Emergency County Hospital, 1, Independentei Boulevard, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Gena","family":"Dascalu","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Gr. T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Gologan","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Gr. T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5590-6462","authenticated-orcid":false,"given":"Georgiana-Emanuela","family":"Gilca-Blanariu","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Gr. T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, St. 1 Spiridon Emergency County Hospital, 1, Independentei Boulevard, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-6058","authenticated-orcid":false,"given":"Madalina-Maria","family":"Diac","sequence":"additional","affiliation":[{"name":"Forensic Sciences Department, Gr. T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Institute of Legal Medicine Iasi, 700455 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-8967","authenticated-orcid":false,"given":"Ion","family":"Sandu","sequence":"additional","affiliation":[{"name":"Science Department, Interdisciplinary Research Institute, Alexandru Ioan Cuza University of Iasi, 11 Carol I Boulevard, 700506 Iasi, Romania"},{"name":"Academy of Romanian Scientists (AORS), 54 Splaiul Independen\u021bei St., Sector 5, 050094 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-7970","authenticated-orcid":false,"given":"Gabriela","family":"Stefanescu","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Gr. T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, St. 1 Spiridon Emergency County Hospital, 1, Independentei Boulevard, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhep.2018.10.033","article-title":"Non-alcoholic fatty liver disease\u2014A global public health perspective","volume":"70","author":"Younossi","year":"2019","journal-title":"J. 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