{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:27:04Z","timestamp":1792168024492,"version":"4.4.0"},"reference-count":65,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ARC Foundation for Cancer Research (9, rue Guy M\u00f4quet, BP 90003, 94803 Villejuif CEDEX, France) through the ELIOS grant (Endoscopic Luminescent Imaging for precision Oncologic Surgery"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Complete mesocolic excision (CME), which involves the adequate resection of the tumor-bearing colonic segment with \u201cen bloc\u201d removal of its mesocolon along embryological fascial planes is associated with superior oncological outcomes. However, CME presents a higher complication rate compared to non-CME resections due to a higher risk of vascular injury. Hyperspectral imaging (HSI) is a contrast-free optical imaging technology, which facilitates the quantitative imaging of physiological tissue parameters and the visualization of anatomical structures. This study evaluates the accuracy of HSI combined with deep learning (DL) to differentiate the colon and its mesenteric tissue from retroperitoneal tissue. In an animal study including 20 pig models, intraoperative hyperspectral images of the sigmoid colon, sigmoid mesentery, and retroperitoneum were recorded. A convolutional neural network (CNN) was trained to distinguish the two tissue classes using HSI data, validated with a leave-one-out cross-validation process. The overall recognition sensitivity of the tissues to be preserved (retroperitoneum) and the tissues to be resected (colon and mesentery) was 79.0 \u00b1 21.0% and 86.0 \u00b1 16.0%, respectively. Automatic classification based on HSI and CNNs is a promising tool to automatically, non-invasively, and objectively differentiate the colon and its mesentery from retroperitoneal tissue.<\/jats:p>","DOI":"10.3390\/diagnostics12092225","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T22:11:10Z","timestamp":1663279870000},"page":"2225","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Computer-Assisted Differentiation between Colon-Mesocolon and Retroperitoneum Using Hyperspectral Imaging (HSI) Technology"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7930-0633","authenticated-orcid":false,"given":"Nariaki","family":"Okamoto","sequence":"first","affiliation":[{"name":"Research Institute against Digestive Cancer (IRCAD), 67091 Strasbourg, France"},{"name":"ICube Laboratory, Photonics Instrumentation for Health, 67081 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-0176","authenticated-orcid":false,"given":"Mar\u00eda Rita","family":"Rodr\u00edguez-Luna","sequence":"additional","affiliation":[{"name":"Research Institute against Digestive Cancer (IRCAD), 67091 Strasbourg, France"},{"name":"ICube Laboratory, Photonics Instrumentation for Health, 67081 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Bencteux","sequence":"additional","affiliation":[{"name":"ICube Laboratory, Photonics Instrumentation for Health, 67081 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-9406","authenticated-orcid":false,"given":"Mahdi","family":"Al-Taher","sequence":"additional","affiliation":[{"name":"Research Institute against Digestive Cancer (IRCAD), 67091 Strasbourg, France"},{"name":"Department of Surgery, Maastricht University Medical Center, 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2186-9421","authenticated-orcid":false,"given":"Lorenzo","family":"Cinelli","sequence":"additional","affiliation":[{"name":"Research Institute against Digestive Cancer (IRCAD), 67091 Strasbourg, France"},{"name":"Department of Gastrointestinal Surgery, San Raffaele Hospital IRCCS, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5664-6746","authenticated-orcid":false,"given":"Eric","family":"Felli","sequence":"additional","affiliation":[{"name":"Research Institute against Digestive Cancer (IRCAD), 67091 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-1777","authenticated-orcid":false,"given":"Takeshi","family":"Urade","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1400-6230","authenticated-orcid":false,"given":"Jacques","family":"Marescaux","sequence":"additional","affiliation":[{"name":"Research Institute against Digestive Cancer (IRCAD), 67091 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8269-6766","authenticated-orcid":false,"given":"Alexandre","family":"Hostettler","sequence":"additional","affiliation":[{"name":"Research Institute against Digestive Cancer (IRCAD), 67091 Strasbourg, France"},{"name":"Research Institute against Digestive Cancer (IRCAD), Kigali, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Collins","sequence":"additional","affiliation":[{"name":"Research Institute against Digestive Cancer (IRCAD), 67091 Strasbourg, France"},{"name":"Research Institute against Digestive Cancer (IRCAD), Kigali, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1390-8486","authenticated-orcid":false,"given":"Michele","family":"Diana","sequence":"additional","affiliation":[{"name":"Research Institute against Digestive Cancer (IRCAD), 67091 Strasbourg, France"},{"name":"ICube Laboratory, Photonics Instrumentation for Health, 67081 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sawicki, T., Ruszkowska, M., Danielewicz, A., Nied\u017awiedzka, E., Ar\u0142ukowicz, T., and Przyby\u0142owicz, K.E. 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