{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:28:44Z","timestamp":1779917324426,"version":"3.53.1"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Direction Central du Service de Sant\u00e9 des Arm\u00e9es (OPEX grant)"},{"name":"Sant\u00e9 Publique France (CNR paludisme grant)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Malaria is one of the most common tropical diseases encountered by members of the French military who are deployed in operations under constrained conditions in malaria-endemic areas. Blood smear microscopy\u2014the gold standard for malaria diagnosis\u2014is often not available in such settings, where the detection of malaria relies on rapid diagnostic tests (RDTs). Ten RDTs (from Biosynex, Carestart, Humasis, SD Bioline, and CTK Biotech), based on the detection of the Plasmodium falciparum histidine-rich protein 2 (HRP2) or lactate dehydrogenase (pLDH, PfLDH, or PvLDH), were assessed against 159 samples collected from imported malaria cases, including 79 P. falciparum, 37 P. vivax, 22 P. ovale, and 21 P. malariae parasites. Samples had been previously characterised using microscopy and real-time PCR. The overall sensitivities for the Plasmodium test ranged from 69.8% (111\/159) to 95% (151\/159). There was no significant difference for the specific detection of P. falciparum (96.2% to 98.7%, p = 0.845). No significant difference was found between sensitivities to P. vivax by pan LDH or pvLDH (81.1% (30\/37) to 94.6% (35\/37) (p = 0.845)). Some of the RDTs missed most of P. ovale and P. malariae, with sensitivities for all RDTs ranging respectively from 4.5% (1\/22) to 81.8% (18\/22) and 14.3% (3\/21) to 95.2% (20\/21). Carestart Malaria Pf\/Pan (pLDH) Ag G0121, a pLDH-based RDT (PfLDH and pLDH), showed the highest sensitivities to P. falciparum (98.7%, 78\/79), P. vivax (94.6%, 35\/37), P. ovale (81.8%, 18\/22), and P. malariae (95.2%, 20\/21) and meets the requirements for military deployments in malaria-endemic areas.<\/jats:p>","DOI":"10.3390\/diagnostics12092240","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T22:12:43Z","timestamp":1663539163000},"page":"2240","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparative Assessment of the Sensitivity of Ten Commercial Rapid Diagnostic Test Kits for the Detection of Plasmodium"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2322-5427","authenticated-orcid":false,"given":"Mathieu","family":"Gendrot","sequence":"first","affiliation":[{"name":"Unit\u00e9 Parasitologie et Entomologie, D\u00e9partement de Microbiologie et Maladies Infectieuses, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 13005 Marseille, France"},{"name":"Aix Marseille University, IRD, AP-HMM, SSA, VITROME, 13005 Marseille, France"},{"name":"IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylin","family":"Madamet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Parasitologie et Entomologie, D\u00e9partement de Microbiologie et Maladies Infectieuses, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 13005 Marseille, France"},{"name":"Aix Marseille University, IRD, AP-HMM, SSA, VITROME, 13005 Marseille, France"},{"name":"IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Fonta","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Parasitologie et Entomologie, D\u00e9partement de Microbiologie et Maladies Infectieuses, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 13005 Marseille, France"},{"name":"Aix Marseille University, IRD, AP-HMM, SSA, VITROME, 13005 Marseille, France"},{"name":"IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Benoit","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Parasitologie et Entomologie, D\u00e9partement de Microbiologie et Maladies Infectieuses, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 13005 Marseille, France"},{"name":"Aix Marseille University, IRD, AP-HMM, SSA, VITROME, 13005 Marseille, France"},{"name":"IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Amalvict","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Parasitologie et Entomologie, D\u00e9partement de Microbiologie et Maladies Infectieuses, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 13005 Marseille, France"},{"name":"Aix Marseille University, IRD, AP-HMM, SSA, VITROME, 13005 Marseille, France"},{"name":"IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Mosnier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Parasitologie et Entomologie, D\u00e9partement de Microbiologie et Maladies Infectieuses, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 13005 Marseille, France"},{"name":"Aix Marseille University, IRD, AP-HMM, SSA, VITROME, 13005 Marseille, France"},{"name":"IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"French National Reference Centre for Imported Malaria Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2360-3803","authenticated-orcid":false,"given":"Bruno","family":"Pradines","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Parasitologie et Entomologie, D\u00e9partement de Microbiologie et Maladies Infectieuses, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 13005 Marseille, France"},{"name":"Aix Marseille University, IRD, AP-HMM, SSA, VITROME, 13005 Marseille, France"},{"name":"IHU M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"ref_1","first-page":"13","article-title":"Le paludisme: Toujours d\u2019actualit\u00e9 dans les arm\u00e9es fran\u00e7aises","volume":"46","author":"Velut","year":"2018","journal-title":"M\u00e9d. 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