{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:36:05Z","timestamp":1767832565053,"version":"3.49.0"},"reference-count":42,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology (MOST)","award":["107-2314-B-038-078-"],"award-info":[{"award-number":["107-2314-B-038-078-"]}]},{"name":"Ministry of Science and Technology (MOST)","award":["108-2314-B-038-049-"],"award-info":[{"award-number":["108-2314-B-038-049-"]}]},{"name":"Ministry of Science and Technology (MOST)","award":["110-2314-B-038-091-"],"award-info":[{"award-number":["110-2314-B-038-091-"]}]},{"name":"Ministry of Science and Technology (MOST)","award":["111-2314-B-038-129-"],"award-info":[{"award-number":["111-2314-B-038-129-"]}]},{"name":"Ministry of Science and Technology (MOST)","award":["105TMU-WFH-02"],"award-info":[{"award-number":["105TMU-WFH-02"]}]},{"name":"Ministry of Science and Technology (MOST)","award":["110-phd-02"],"award-info":[{"award-number":["110-phd-02"]}]},{"name":"Taipei Medical University-Wan Fang Hospital","award":["107-2314-B-038-078-"],"award-info":[{"award-number":["107-2314-B-038-078-"]}]},{"name":"Taipei Medical University-Wan Fang Hospital","award":["108-2314-B-038-049-"],"award-info":[{"award-number":["108-2314-B-038-049-"]}]},{"name":"Taipei Medical University-Wan Fang Hospital","award":["110-2314-B-038-091-"],"award-info":[{"award-number":["110-2314-B-038-091-"]}]},{"name":"Taipei Medical University-Wan Fang Hospital","award":["111-2314-B-038-129-"],"award-info":[{"award-number":["111-2314-B-038-129-"]}]},{"name":"Taipei Medical University-Wan Fang Hospital","award":["105TMU-WFH-02"],"award-info":[{"award-number":["105TMU-WFH-02"]}]},{"name":"Taipei Medical University-Wan Fang Hospital","award":["110-phd-02"],"award-info":[{"award-number":["110-phd-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The present study proposes a cognitive prosthesis device for face memory impairment as a proof-of-concept for the domain-specific cognitive prosthesis. Healthy subjects (n = 6) and a patient with poor face memory were enrolled. An acquaintance face recognition test with and without the use of cognitive prosthesis for face memory impairment, face recognition tests, quality of life, neuropsychological assessments, and machine learning performance of the cognitive prosthesis were followed-up throughout four weeks of real-world device use by the patient. The healthy subjects had an accuracy of 92.38 \u00b1 4.41% and reaction time of 1.27 \u00b1 0.12 s in the initial attempt of the acquaintance face recognition test, which changed to 80.48 \u00b1 6.23% (p = 0.06) and 2.11 \u00b1 0.20 s (p &lt; 0.01) with prosthesis use. The patient had an accuracy of 74.29% and a reaction time of 6.65 s, which improved to 94.29% and 3.28 s with prosthesis use. After four weeks, the patient\u2019s unassisted accuracy and reaction time improved to 100% and 1.23 s. Functional MRI study revealed activation of the left superior temporal lobe during face recognition task without prosthesis use and activation of the right precentral motor area with prosthesis use. The prosthesis could improve the patient\u2019s performance by bypassing the brain area inefficient for facial recognition and employing the area more efficiently for the cognitive task.<\/jats:p>","DOI":"10.3390\/diagnostics12092242","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T22:12:43Z","timestamp":1663539163000},"page":"2242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Domain-Specific Cognitive Prosthesis for Face Memory and Recognition"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9979-6779","authenticated-orcid":false,"given":"Jowy","family":"Tani","sequence":"first","affiliation":[{"name":"Department of Neurology, Wan Fang Hospital, Taipei Medical University, Taipei 116079, Taiwan"},{"name":"Biomed Innovation Center, Wan Fang Hospital, Taipei Medical University, Taipei 116079, Taiwan"},{"name":"Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan"},{"name":"Taipei Medical University Biomed Accelerator, Taipei Medical University, Taipei 106339, Taiwan"},{"name":"Taipei Medical University Biodesign Center, Taipei Medical University, Taipei 106339, Taiwan"},{"name":"Taipei Neuroscience Institute, Taipei Medical University, New Taipei City 235041, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"Biomed Innovation Center, Wan Fang Hospital, Taipei Medical University, Taipei 116079, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6278-9217","authenticated-orcid":false,"given":"Chao-Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Biomed Innovation Center, Wan Fang Hospital, Taipei Medical University, Taipei 116079, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4033-5481","authenticated-orcid":false,"given":"Co Yih","family":"Siow","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei 110301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsui-San","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Yang","sequence":"additional","affiliation":[{"name":"MediXgraph Inc., Fremont, CA 94555, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Yao","sequence":"additional","affiliation":[{"name":"MediXgraph Inc., Fremont, CA 94555, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-5967","authenticated-orcid":false,"given":"Chaur-Jong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan"},{"name":"Taipei Neuroscience Institute, Taipei Medical University, New Taipei City 235041, Taiwan"},{"name":"Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235041, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0534-7882","authenticated-orcid":false,"given":"Jia-Ying","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wan Fang Hospital, Taipei Medical University, Taipei 116079, Taiwan"},{"name":"Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan"},{"name":"Taipei Neuroscience Institute, Taipei Medical University, New Taipei City 235041, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nrneurol.2014.181","article-title":"Classifying neurocognitive disorders: The DSM-5 approach","volume":"10","author":"Sachdev","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1001\/jama.2014.13806","article-title":"The diagnosis and management of mild cognitive impairment: A clinical review","volume":"312","author":"Langa","year":"2014","journal-title":"JAMA"},{"key":"ref_3","first-page":"80","article-title":"Post-stroke cognitive impairment: Epidemiology, mechanisms and management","volume":"2","author":"Sun","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fneur.2019.00198","article-title":"Cognitive Impairment Following Acute Mild Traumatic Brain Injury","volume":"10","author":"Faleiro","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s13054-016-1376-4","article-title":"The neurological and cognitive consequences of hyperthermia","volume":"20","author":"Walter","year":"2016","journal-title":"Crit. Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/00006842-200205000-00016","article-title":"Assessing quality of life in older adults with cognitive impairment","volume":"64","author":"Logsdon","year":"2002","journal-title":"Psychosom. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3233\/NRE-182618","article-title":"Cognitive impairment and health-related quality of life following traumatic brain injury","volume":"44","author":"Gorgoraptis","year":"2019","journal-title":"NeuroRehabilitation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2147\/JMDH.S209106","article-title":"Burden of caring for people with dementia\u2014Comparing family caregivers and professional caregivers. A descriptive study","volume":"12","author":"Seidel","year":"2019","journal-title":"J. Multidiscip. Healthc."},{"key":"ref_9","unstructured":"Patterson, C. (2018). World Alzheimer Report 2018: The State of the Art of Dementia Research: New Frontiers, Alzheimer\u2019s Disease International."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3233\/JAD-190367","article-title":"A Clinical Trial of Transcranial Electromagnetic Treatment in Alzheimer\u2019s Disease: Cognitive Enhancement and Associated Changes in Cerebrospinal Fluid, Blood, and Brain Imaging","volume":"71","author":"Arendash","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1080\/13607863.2015.1132677","article-title":"Computer-based cognitive interventions for people living with dementia: A systematic literature review and meta-analysis","volume":"21","author":"Loizeau","year":"2017","journal-title":"Aging Ment. Health"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41562-019-0672-9","article-title":"Cognitive prostheses for goal achievement","volume":"3","author":"Lieder","year":"2019","journal-title":"Nat. Hum. Behav."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1038\/s41598-021-84288-5","article-title":"Quantifying the alignment error and the effect of incomplete somatosensory feedback on motor performance in a virtual brain\u2013computer-interface setup","volume":"11","author":"Dyck","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"14171","DOI":"10.1038\/s41598-020-70379-2","article-title":"Haptic sound-localisation for use in cochlear implant and hearing-aid users","volume":"10","author":"Fletcher","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_15","unstructured":"Vermette, L., Chilana, P., Terry, M., Fourney, A., Lafreniere, B., and Kerr, T. (2015, January 3\u20135). CheatSheet: A contextual interactive memory aid for web applications. Proceedings of the 41st Graphics Interface Conference, Halifax, NS, Canada."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1177\/1471301217735180","article-title":"Electronic memory aids for people with dementia experiencing prospective memory loss: A review of empirical studies","volume":"18","author":"King","year":"2019","journal-title":"Dementia"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hodges, S., Williams, L., Berry, E., Izadi, S., Srinivasan, J., Butler, A., Smyth, G., Kapur, N., and Wood, K. (2006, January 17\u201321). SenseCam: A retrospective memory aid. Proceedings of the International Conference on Ubiquitous Computing, Orange County, CA, USA.","DOI":"10.1007\/11853565_11"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/09602011.2015.1128450","article-title":"A critical review of the effects of wearable cameras on memory","volume":"28","author":"Silva","year":"2018","journal-title":"Neuropsychol. Rehabil."},{"key":"ref_19","unstructured":"Wieser, I., Toprak, S., Grenzing, A., Hinz, T., Auddy, S., Karao\u011fuz, E.C., Chandran, A., Remmels, M., El Shinawi, A., and Josifovski, J. (2019, January 21\u201325). A Robotic Home Assistant with Memory Aid Functionality. Proceedings of the Joint German\/Austrian Conference on Artificial Intelligence (K\u00fcnstliche Intelligenz), Bamberg, Germany."},{"key":"ref_20","first-page":"52","article-title":"A kinect-based wearable face recognition system to aid visually impaired users","volume":"47","author":"Neto","year":"2016","journal-title":"IEEE Trans. Hum. Mach. Syst."},{"key":"ref_21","unstructured":"Chaudhry, S., and Chandra, R. (2015). Design of a mobile face recognition system for visually impaired persons. arXiv."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Krishna, S., Little, G., Black, J., and Panchanathan, S. (2005, January 9\u201312). A wearable face recognition system for individuals with visual impairments. Proceedings of the 7th international ACM SIGACCESS Conference on Computers and Accessibility, New York, NY, USA.","DOI":"10.1145\/1090785.1090806"},{"key":"ref_23","first-page":"233","article-title":"Age Differences in Face Memory and Face Processing Between Younger and Older Adults in Taiwan","volume":"58","author":"Cheng","year":"2016","journal-title":"Chin. J. Psychol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/2150135111422720","article-title":"Design control requirements for medical device development","volume":"3","author":"Kinsel","year":"2012","journal-title":"World J. Pediatr. Congenit. Heart Surg."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Yock, P.G. (2015). Biodesign: The Process of Innovating Medical Technologies, Cambridge University Press. [2nd ed.].","DOI":"10.1017\/CBO9781316095843"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Schroff, F., Kalenichenko, D., and Philbin, J. (2015, January 7\u201312). Facenet: A unified embedding for face recognition and clustering. Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, Boston, MA, USA.","DOI":"10.1109\/CVPR.2015.7298682"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"S\u00e9guin, J.A., Scharff, A., and Pedersen, K. (2019, January 4\u20139). Triptech: A Method for Evaluating Early Design Concepts. Proceedings of the Extended Abstracts of the 2019 CHI Conference on Human Factors in Computing Systems, Glasgow, Scotland, UK.","DOI":"10.1145\/3290607.3299061"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Wechsler, D. (2008). Wechsler Adult Intelligence Scale\u2014Fourth Edition (WAIS\u2013IV), NCS Pearson.","DOI":"10.1037\/t15169-000"},{"key":"ref_29","first-page":"676","article-title":"Factor structure and explanatory variables of the Mini-Mental State Examination (MMSE) for elderly persons in Taiwan","volume":"100","author":"Shyu","year":"2001","journal-title":"J. Med. Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0010-9452(76)80035-4","article-title":"A modified card sorting test sensitive to frontal lobe defects","volume":"12","author":"Nelson","year":"1976","journal-title":"Cortex A J. Devoted Study Nerv. Syst. Behav."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Wechsler, D. (1945). Wechsler, D. Wechsler Memory Scale. Wechsler Memory Scale, Psychological Corporation.","DOI":"10.1037\/t27207-000"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1001\/archneur.1978.00500300038006","article-title":"Visuospatial judgment. A clinical test","volume":"35","author":"Benton","year":"1978","journal-title":"Arch. Neurol."},{"key":"ref_33","unstructured":"Benton, A.L., deS Hamsher, K., and Sivan, A.B. (1994). Multilingual Aphasia Examination, AJA associates."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med. Care"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Weinger, M.B., Gardner-Bonneau, D.J., and Wiklund, M.E. (2010). Handbook of Human Factors in Medical Device Design, CRC Press.","DOI":"10.1201\/b10439"},{"key":"ref_36","first-page":"4","article-title":"SUS-A quick and dirty usability scale","volume":"189","author":"Brooke","year":"1996","journal-title":"Usability Eval. Ind."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ipm.2009.03.002","article-title":"A systematic analysis of performance measures for classification tasks","volume":"45","author":"Sokolova","year":"2009","journal-title":"Inf. Process. Manag."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.neuropsychologia.2005.07.001","article-title":"The Cambridge Face Memory Test: Results for neurologically intact individuals and an investigation of its validity using inverted face stimuli and prosopagnosic participants","volume":"44","author":"Duchaine","year":"2006","journal-title":"Neuropsychologia"},{"key":"ref_39","first-page":"395","article-title":"Do SF-36 summary component scores accurately summarize subscale scores?","volume":"10","author":"Taft","year":"2001","journal-title":"Qual. Life Res. Int. J. Qual. Life Asp. Treat. Care Rehabil."},{"key":"ref_40","unstructured":"Card, S.K., Newell, A., and Moran, T.P. (1983). The Psychology of Human-Computer Interaction, L. Erlbaum Associates Inc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1097\/00001756-200106130-00014","article-title":"A functional MRI study of face recognition in patients with prosopagnosia","volume":"12","author":"Marotta","year":"2001","journal-title":"Neuroreport"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1097\/00001756-200112210-00029","article-title":"A left-lateralized network for reading Chinese words: A 3 T fMRI study","volume":"12","author":"Kuo","year":"2001","journal-title":"Neuroreport"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/9\/2242\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:33:13Z","timestamp":1760142793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/9\/2242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,16]]},"references-count":42,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["diagnostics12092242"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12092242","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,16]]}}}