{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:36:14Z","timestamp":1762068974015,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Neurology and the Department of Nuclear Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Progressive Supranuclear Palsy\u2014Parkinsonism Predominant (PSP-P) is associated with moderate responsiveness to levodopa treatment and a possible lack of typical PSP milestones. The clinical manifestation of PSP-P poses difficulties in neurological examination. In the early stages it is often misdiagnosed as Parkinson\u2019s Disease, and in the more advanced stages PSP-P shows more symptoms in common with Multiple System Atrophy\u2014Parkinsonian type (MSA-P). The small number of tools enabling differential diagnosis of PSP-P and MSA leads to the necessity of searching for parameters facilitating in vivo diagnosis. In this study, 14 patients with PSP-P and 21 patients with MSA-P were evaluated using Single Photon Emission Computed Tomography. Considering the fact that PSP is linked with frontal deficits, regions of the frontal lobe were assessed in the context of hypoperfusion and their possible usefulness in the differential diagnosis with MSA-P. The outcome of the work revealed that the right middle frontal gyrus was the region most significantly affected in PSP-P.<\/jats:p>","DOI":"10.3390\/diagnostics12102421","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T01:52:21Z","timestamp":1665193941000},"page":"2421","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Assessment of Subregions in the Frontal Lobe May Be Feasible in the Differential Diagnosis of Progressive Supranuclear Palsy\u2014Parkinsonism Predominant (PSP-P) and Multiple System Atrophy (MSA)"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-6817","authenticated-orcid":false,"given":"Piotr","family":"Alster","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, 03-242 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8685-475X","authenticated-orcid":false,"given":"Natalia","family":"Madetko-Alster","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, 03-242 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-8121","authenticated-orcid":false,"given":"Bartosz","family":"Migda","sequence":"additional","affiliation":[{"name":"Diagnostic Ultrasound Lab, Department of Pediatric Radiology, Medical Faculty, Medical University of Warsaw, 03-242 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Nieciecki","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Children\u2019s Memorial Health Institute, 04-736 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Koziorowski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, 03-242 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leszek","family":"Kr\u00f3licki","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.parkreldis.2021.01.015","article-title":"Association of PSP phenotypes with survival: A brain-bank study","volume":"84","author":"Guasp","year":"2021","journal-title":"Park. Relat. Disord."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/aian.AIAN_611_20","article-title":"Subtypes of PSP and Prognosis: A Retrospective Analysis","volume":"24","author":"Mahale","year":"2021","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref_3","first-page":"331","article-title":"Diagnosis of MSA-P and PSP-P in Early Stage","volume":"72","author":"Yamawaki","year":"2020","journal-title":"Brain Nerve"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"630153","DOI":"10.3389\/fneur.2021.630153","article-title":"The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome-A Pilot Study","volume":"12","author":"Alster","year":"2021","journal-title":"Front. Neurol."},{"doi-asserted-by":"crossref","unstructured":"Madetko, N., Alster, P., Kuty\u0142owski, M., Migda, B., Nieciecki, M., Koziorowski, D., and Kr\u00f3licki, L. (2022). Is MRPI 2.0 More Useful than MRPI and M\/P Ratio in Differential Diagnosis of PSP-P with Other Atypical Parkinsonisms?. J. Clin. Med., 11.","key":"ref_5","DOI":"10.3390\/jcm11102701"},{"doi-asserted-by":"crossref","unstructured":"Alster, P., Nieciecki, M., Migda, B., Kuty\u0142owski, M., Madetko, N., Duszy\u0144ska-W\u0105s, K., Charzy\u0144ska, I., Koziorowski, D., Kr\u00f3licki, L., and Friedman, A. (2022). The Strengths and Obstacles in the Differential Diagnosis of Progressive Supranuclear Palsy-Parkinsonism Predominant (PSP-P) and Multiple System Atrophy (MSA) Using Magnetic Resonance Imaging (MRI) and Perfusion Single Photon Emission Computed Tomography (SPECT). Diagnostics, 12.","key":"ref_6","DOI":"10.3390\/diagnostics12020385"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/mds.28992","article-title":"Development and Validation of Automated Magnetic Resonance Parkinsonism Index 2.0 to Distinguish Progressive Supranuclear Palsy-Parkinsonism From Parkinson\u2019s Disease","volume":"37","author":"Quattrone","year":"2022","journal-title":"Mov. Disord."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.parkreldis.2020.01.019","article-title":"Magnetic Resonance Parkinsonism Index for evaluating disease progression rate in progressive supranuclear palsy: A longitudinal 2-year study","volume":"72","author":"Quattrone","year":"2020","journal-title":"Park. Relat. 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