{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:20:40Z","timestamp":1777890040358,"version":"3.51.4"},"reference-count":24,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japan Society for Promoting Science","award":["19K09840"],"award-info":[{"award-number":["19K09840"]}]},{"name":"Japan Society for Promoting Science","award":["STSC20001"],"award-info":[{"award-number":["STSC20001"]}]},{"name":"Japan Society for Promoting Science","award":["A-243"],"award-info":[{"award-number":["A-243"]}]},{"name":"Japan Society for Promoting Science","award":["2019-Cancer in general-02"],"award-info":[{"award-number":["2019-Cancer in general-02"]}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["19K09840"],"award-info":[{"award-number":["19K09840"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["STSC20001"],"award-info":[{"award-number":["STSC20001"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["A-243"],"award-info":[{"award-number":["A-243"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["2019-Cancer in general-02"],"award-info":[{"award-number":["2019-Cancer in general-02"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan Agency for Medical Research and Development (AMED)","award":["19K09840"],"award-info":[{"award-number":["19K09840"]}]},{"name":"Japan Agency for Medical Research and Development (AMED)","award":["STSC20001"],"award-info":[{"award-number":["STSC20001"]}]},{"name":"Japan Agency for Medical Research and Development (AMED)","award":["A-243"],"award-info":[{"award-number":["A-243"]}]},{"name":"Japan Agency for Medical Research and Development (AMED)","award":["2019-Cancer in general-02"],"award-info":[{"award-number":["2019-Cancer in general-02"]}]},{"name":"National Hospital Organization Multi-center clinical study","award":["19K09840"],"award-info":[{"award-number":["19K09840"]}]},{"name":"National Hospital Organization Multi-center clinical study","award":["STSC20001"],"award-info":[{"award-number":["STSC20001"]}]},{"name":"National Hospital Organization Multi-center clinical study","award":["A-243"],"award-info":[{"award-number":["A-243"]}]},{"name":"National Hospital Organization Multi-center clinical study","award":["2019-Cancer in general-02"],"award-info":[{"award-number":["2019-Cancer in general-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>(1) Background\/Aim: In clinical practice, uterine lipoleiomyomas are variants of uterine leiomyomas that are often found incidentally and do not require surgical treatment unless the patient is symptomatic. Therefore, these should be clinically differentiated from lesions that need surgical treatment. Conversely, hemangiomas, or blood vessel benign tumors, rarely develop in the uterus; however, many clinical complications such as abdominal pain and excessive vaginal bleeding result from a uterine hemangioma. Hemangiomas can occur at any age and primarily affect pregnant women. (2) Materials and Methods: The oncological properties of uterine lipoleiomyoma and hemangioma in adults were investigated using molecular pathological examination on tissue excised from patients with a uterine tumor. (3) Results: Through molecular pathological studies, which included potential biomarkers for uterine mesenchymal tumors, a differential diagnosis was established for a case of mesenchymal tumor. Herein, we report a 54-year-old non-pregnant woman who presented with vaginal bleeding and underwent hysterectomy after detection of a 140 \u00d7 100 mm intramural mass diagnosed as a concurrent uterine hemangioma and lipoleiomyoma after molecular histopathologic examinations. (4) Conclusion: As far as we know, our case is the first patient of concurrent uterine hemangioma and lipoleiomyoma. Hence, the possibility of several types of mesenchymal tumors must be considered in the differential diagnosis of patients with abnormal vaginal bleeding. As such, molecular pathological examination and close monitoring of the MRI results should be conducted by medical staff while considering the patient\u2019s desire for pregnancy, including surgical treatment options for uterine hemangioma.<\/jats:p>","DOI":"10.3390\/diagnostics12102468","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T20:53:29Z","timestamp":1665608009000},"page":"2468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Characteristic of Concurrent Uterine Lipoleiomyoma and Hemangioma by Algorithm of Candidate Biomarkers for Uterine Mesenchymal Tumor"],"prefix":"10.3390","volume":"12","author":[{"given":"Shoko","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto 606-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7525-2048","authenticated-orcid":false,"given":"Takuma","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Section of Cancer Medicine, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan"},{"name":"Seeds Development and Research Infrastructure Division, Japan Agency for Medical Research and Development (AMED), Tokyo 100-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto 606-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Yaegashi","sequence":"additional","affiliation":[{"name":"Seeds Development and Research Infrastructure Division, Japan Agency for Medical Research and Development (AMED), Tokyo 100-0004, Japan"},{"name":"Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Miyagi 980-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Abiko","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto 606-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto 606-8501, Japan"},{"name":"Seeds Development and Research Infrastructure Division, Japan Agency for Medical Research and Development (AMED), Tokyo 100-0004, Japan"},{"name":"Department of Obstetrics and Gynecology, Kyoto University School of Medicine, Kyoto 606-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"ref_1","unstructured":"WHO Classification of Tumours Editorial Board (2020). 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