{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:49:15Z","timestamp":1780505355680,"version":"3.54.1"},"reference-count":132,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Numerous prognostic indexes have been developed in hematological diseases based on patient characteristics and genetic or molecular assessment. However, less attention was paid to more accessible parameters, such as neutrophils, lymphocytes, monocytes, and platelet counts. Although many studies have defined the role of neutrophil-to-lymphocyte or platelet-to-lymphocyte in lymphoid malignancies, few applications exist for myeloid neoplasm or hematopoietic stem cell transplantation procedures. In this review, we synthesized literature data on the prognostic value of count blood cells in myeloid malignancies and hematopoietic stem cell transplantation in the context of classical prognostic factors and clinical outcomes.<\/jats:p>","DOI":"10.3390\/diagnostics12102493","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:04:55Z","timestamp":1665965095000},"page":"2493","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic Role of Cell Blood Count in Chronic Myeloid Neoplasm and Acute Myeloid Leukemia and Its Possible Implications in Hematopoietic Stem Cell Transplantation"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7487-3328","authenticated-orcid":false,"given":"Olga","family":"Mulas","sequence":"first","affiliation":[{"name":"Hematology Unit, Businco Hospital, ARNAS G. Brotzu, 09124 Cagliari, Italy"},{"name":"Department of Medical Sciences and Public Health, University of Cagliari, S554, km 4500, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunella","family":"Mola","sequence":"additional","affiliation":[{"name":"Hematology Unit, Businco Hospital, ARNAS G. Brotzu, 09124 Cagliari, Italy"},{"name":"Department of Medical Sciences and Public Health, University of Cagliari, S554, km 4500, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clelia","family":"Madeddu","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health, University of Cagliari, S554, km 4500, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Caocci","sequence":"additional","affiliation":[{"name":"Hematology Unit, Businco Hospital, ARNAS G. Brotzu, 09124 Cagliari, Italy"},{"name":"Department of Medical Sciences and Public Health, University of Cagliari, S554, km 4500, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0577-7217","authenticated-orcid":false,"given":"Antonio","family":"Macci\u00f2","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Businco Hospital, ARNAS G. Brotzu, 09124 Cagliari, Italy"},{"name":"Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio La","family":"Nasa","sequence":"additional","affiliation":[{"name":"Hematology Unit, Businco Hospital, ARNAS G. Brotzu, 09124 Cagliari, Italy"},{"name":"Department of Medical Sciences and Public Health, University of Cagliari, S554, km 4500, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ircmb.2021.09.001","article-title":"Classical Philadelphia-negative myeloproliferative neoplasms (MPNs): A continuum of different disease entities","volume":"365","author":"Coltro","year":"2021","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/ijlh.12365","article-title":"ICSH guidelines for the standardization of bone marrow immunohistochemistry","volume":"37","author":"Torlakovic","year":"2015","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jinf.2019.02.006","article-title":"The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis","volume":"78","author":"Russell","year":"2019","journal-title":"J. Infect."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3109\/09513590.2015.1126711","article-title":"An evaluation of homocysteine, C-reactive protein, lipid levels, neutrophils to lymphocyte ratio in postmenopausal osteopenic women","volume":"32","author":"Liu","year":"2016","journal-title":"Gynecol. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.amjsurg.2019.04.018","article-title":"Neutrophil-to-lymphocyte ratio predicts acute appendicitis and distinguishes between complicated and uncomplicated appendicitis: A systematic review and meta-analysis","volume":"219","author":"Hajibandeh","year":"2020","journal-title":"Am. J. Surg."},{"key":"ref_7","first-page":"333","article-title":"An increased neutrophil\/lymphocyte ratio is an early warning signal of severe COVID-19","volume":"40","author":"Xia","year":"2020","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.clinbiochem.2017.11.008","article-title":"Neutrophil to lymphocyte ratio predict mortality and major adverse cardiac events in acute coronary syndrome: A systematic review and meta-analysis","volume":"52","author":"Dong","year":"2018","journal-title":"Clin. Biochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"dju124","DOI":"10.1093\/jnci\/dju124","article-title":"Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: A systematic review and meta-analysis","volume":"106","author":"Templeton","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.2147\/CMAR.S245928","article-title":"The Neutrophil to Lymphocyte and Lymphocyte to Monocyte Ratios as New Prognostic Factors in Hematological Malignancies\u2014A Narrative Review","volume":"12","author":"Stefaniuk","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"347270","DOI":"10.1155\/2015\/347270","article-title":"The Hematopoietic Niche in Myeloproliferative Neoplasms","volume":"2015","author":"Nitschke","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13058-016-0794-1","article-title":"Prognostic role of neutrophil-to-lymphocyte ratio in breast cancer: A systematic review and meta-analysis","volume":"19","author":"Ethier","year":"2017","journal-title":"Breast Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1158\/0008-5472.CAN-18-3962","article-title":"The Tumor Microenvironment Innately Modulates Cancer Progression","volume":"79","author":"Hinshaw","year":"2019","journal-title":"Cancer Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"606819","DOI":"10.1155\/2015\/606819","article-title":"Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm","volume":"2015","author":"Fleischman","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"598182","DOI":"10.3389\/fmed.2021.598182","article-title":"Cytokine Consistency Between Bone Marrow and Peripheral Blood in Patients with Philadelphia-Negative Myeloproliferative Neoplasms","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/MOH.0000000000000251","article-title":"Microenvironmental regulation of hematopoietic stem cells and its implications in leukemogenesis","volume":"23","author":"Seshadri","year":"2016","journal-title":"Curr. Opin. Hematol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.3389\/fimmu.2020.01540","article-title":"Regulation of the Bone Marrow Niche by Inflammation","volume":"11","author":"Mitroulis","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1056\/NEJMoa041869","article-title":"Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells","volume":"351","author":"Dave","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1038\/bcj.2011.53","article-title":"Entourage: The immune microenvironment following follicular lymphoma","volume":"2","author":"Wahlin","year":"2012","journal-title":"Blood Cancer J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.14694\/EdBook_AM.2013.33.e91","article-title":"Cellular composition of the tumor microenvironment","volume":"33","author":"Ansell","year":"2013","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.18632\/oncotarget.14289","article-title":"Lymphocyte-to-monocyte ratio is associated with prognosis of diffuse large B-cell lymphoma: Correlation with CD163 positive M2 type tumor-associated macrophages, not PD-1 positive tumor-infiltrating lymphocytes","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/bjc.2011.189","article-title":"The prognostic influence of tumour-infiltrating lymphocytes in cancer: A systematic review with meta-analysis","volume":"105","author":"Gooden","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1186\/s12935-021-02089-2","article-title":"New insights into M1\/M2 macrophages: Key modulators in cancer progression","volume":"21","author":"Liu","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/ijc.29046","article-title":"Granulocyte colony-stimulating factor off-target effect on nerve outgrowth promotes prostate cancer development","volume":"136","author":"Dobrenis","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/2211-5463.13445","article-title":"G-CSF\/GM-CSF-induced hematopoietic dysregulation in the progression of solid tumors","volume":"12","author":"He","year":"2022","journal-title":"FEBS Open Bio"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Markovi\u0107, D., Maslovari\u0107, I., Djiki\u0107, D., and \u010coki\u0107, V.P. (2022). Neutrophil Death in Myeloproliferative Neoplasms: Shedding More Light on Neutrophils as a Pathogenic Link to Chronic Inflammation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031490"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1158\/2159-8290.CD-14-0736","article-title":"JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response","volume":"5","author":"Kleppe","year":"2015","journal-title":"Cancer Discov."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1182\/blood-2006-10-048298","article-title":"Increased adhesion to endothelial cells of erythrocytes from patients with polycythemia vera is mediated by laminin alpha5 chain and Lu\/BCAM","volume":"110","author":"Wautier","year":"2007","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jaccao.2022.04.002","article-title":"Cardiovascular Disease in Myeloproliferative Neoplasms","volume":"4","author":"Leiva","year":"2022","journal-title":"JACC CardioOncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1056\/NEJM199907153410306","article-title":"The biology of chronic myeloid leukemia","volume":"341","author":"Faderl","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e468","DOI":"10.1097\/HS9.0000000000000468","article-title":"Chronic Myeloid Leukemia in 2020","volume":"4","author":"Hehlmann","year":"2020","journal-title":"Hemasphere"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1182\/blood.V63.4.789.789","article-title":"Prognostic discrimination in \u201cgood-risk\u201d chronic granulocytic leukemia","volume":"63","author":"Sokal","year":"1984","journal-title":"Blood"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1182\/blood-2010-12-319038","article-title":"Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: The EUTOS score","volume":"118","author":"Hasford","year":"2011","journal-title":"Blood"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/leu.2015.261","article-title":"Prognosis of long-term survival considering disease-specific death in patients with chronic myeloid leukemia","volume":"30","author":"Pfirrmann","year":"2016","journal-title":"Leukemia"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"739171","DOI":"10.3389\/fonc.2021.739171","article-title":"Prognostic Factors for Overall Survival in Chronic Myeloid Leukemia Patients: A Multicentric Cohort Study by the Italian CML GIMEMA Network","volume":"11","author":"Specchia","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1182\/blood.V124.21.4538.4538","article-title":"Correlation of Lymphocyte Count with Treatment Response to Tyrosine Kinase Inhibitors in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase","volume":"124","author":"Sasaki","year":"2014","journal-title":"Blood"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.critrevonc.2013.10.005","article-title":"Dasatinib, large granular lymphocytosis, and pleural effusion: Useful or adverse effect?","volume":"89","author":"Paydas","year":"2014","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_39","first-page":"319","article-title":"Significance of Lymphocyte Count, Monocyte Count, and Lymphocyte-To-Monocyte Ratio in Predicting Molecular Response in Patients with Chronic Myeloid Leukemia: A Single-Centre Experience","volume":"66","author":"Buyukkurt","year":"2020","journal-title":"Clin. Lab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.hoc.2020.12.001","article-title":"Overview of Myeloproliferative Neoplasms: History, Pathogenesis, Diagnostic Criteria, and Complications","volume":"35","author":"Tremblay","year":"2021","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"12367","DOI":"10.2147\/OTT.S287944","article-title":"Impact of Mutational Profile on the Management of Myeloproliferative Neoplasms: A Short Review of the Emerging Data","volume":"13","author":"Loscocco","year":"2020","journal-title":"OncoTargets Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/s41375-018-0077-1","article-title":"Philadelphia chromosome-negative classical myeloproliferative neoplasms: Revised management recommendations from European LeukemiaNet","volume":"32","author":"Barbui","year":"2018","journal-title":"Leukemia"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1002\/ajh.26008","article-title":"Polycythemia vera and essential thrombocythemia: 2021 update on diagnosis, risk-stratification and management","volume":"95","author":"Tefferi","year":"2020","journal-title":"Am. J. Hematol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1182\/blood.2019000943","article-title":"Leukemia secondary to myeloproliferative neoplasms","volume":"136","author":"Dunbar","year":"2020","journal-title":"Blood"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.hoc.2020.11.006","article-title":"Thrombotic, Vascular, and Bleeding Complications of the Myeloproliferative Neoplasms","volume":"35","author":"Schafer","year":"2021","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1200\/JCO.2005.07.062","article-title":"Vascular and Neoplastic Risk in a Large Cohort of Patients with Polycythemia Vera","volume":"23","author":"Marchioli","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1182\/blood-2012-01-403279","article-title":"A prognostic model to predict survival in 867 World Health Organization\u2013defined essential thrombocythemia at diagnosis: A study by the International Working Group on Myelofibrosis Research and Treatment","volume":"120","author":"Passamonti","year":"2012","journal-title":"Blood"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.7314\/APJCP.2015.16.13.5159","article-title":"Evaluation of Inflammation Parameters in Philadelphia Negative Chronic Myeloproliferative Neoplasia Patients","volume":"16","author":"Hacibekiroglu","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_49","first-page":"3036","article-title":"The ratio of platelet\/lymphocyte, the ratio of neutrophil\/lymphocyte and some haemogram parameters related to thrombosis in essential thrombocytosis and polycythaemia vera","volume":"28","author":"Kocak","year":"2017","journal-title":"Biomed Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.leukres.2018.03.013","article-title":"Clinico-hematological profile and thrombotic\/hemorrhagic events in 150 chinese patients with essential thrombocythemia","volume":"69","author":"Zhou","year":"2018","journal-title":"Leuk. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1182\/blood-2006-08-042515","article-title":"Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera","volume":"109","author":"Landolfi","year":"2007","journal-title":"Blood"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1365-2141.2007.06674.x","article-title":"Leucocytosis in polycythaemia vera predicts both inferior survival and leukaemic transformation","volume":"138","author":"Gangat","year":"2007","journal-title":"Br. J. Haematol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/bjh.12117","article-title":"Leucocytosis and thrombosis at diagnosis are associated with poor survival in polycythaemia vera: A population-based study of 327 patients","volume":"160","author":"Bonicelli","year":"2013","journal-title":"Br. J. Haematol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1038\/modpathol.2015.100","article-title":"Neutrophilic leukocytosis in advanced stage polycythemia vera: Hematopathologic features and prognostic implications","volume":"28","author":"Boiocchi","year":"2015","journal-title":"Mod. Pathol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1182\/blood.2019003347","article-title":"Persistent leukocytosis in polycythemia vera is associated with disease evolution but not thrombosis","volume":"135","author":"Ronner","year":"2020","journal-title":"Blood"},{"key":"ref_56","first-page":"e145","article-title":"Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as prognostic biomarkers in polycythemia vera","volume":"44","author":"Holik","year":"2022","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_57","unstructured":"Carobbio, A., Vannucchi, A.M., Guglielmelli, P., and Loscocco, G.G. (2022, July 31). Neutrophil-to-Lymphocyte Ratio (NLR) Is a Risk Factor for Venous Thrombosis in Polycythemia Vera\u2014ScienceDirect. Available online: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006497121034698."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"E35","DOI":"10.1002\/ajh.26423","article-title":"Deciphering the individual contribution of absolute neutrophil and monocyte counts to thrombosis risk in polycythemia vera and essential thrombocythemia","volume":"97","author":"Farrukh","year":"2022","journal-title":"Am. J. Hematol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2022.02.006","article-title":"Thrombosis in patients with post-polycythemia vera myelofibrosis: Incidence and risk factors","volume":"212","author":"Teng","year":"2022","journal-title":"Thromb. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/ajh.26050","article-title":"Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management","volume":"96","author":"Tefferi","year":"2021","journal-title":"Am. J. Hematol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1182\/blood-2007-11-121434","article-title":"A dynamic prognostic model to predict survival in post-polycythemia vera myelofibrosis","volume":"111","author":"Passamonti","year":"2008","journal-title":"Blood"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1200\/JCO.2010.32.2446","article-title":"DIPSS plus: A refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status","volume":"29","author":"Gangat","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1182\/blood-2008-07-170449","article-title":"New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment","volume":"113","author":"Cervantes","year":"2009","journal-title":"Blood"},{"key":"ref_64","first-page":"3157","article-title":"Elevated Neutrophil-to-Lymphocyte-ratio and Platelet-to-Lymphocyte Ratio in Myelofibrosis: Inflammatory Biomarkers or Representatives of Myeloproliferation Itself?","volume":"38","author":"Lucijanic","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00508-018-1318-z","article-title":"Assessing serum albumin concentration, lymphocyte count and prognostic nutritional index might improve prognostication in patients with myelofibrosis","volume":"130","author":"Lucijanic","year":"2018","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/ajh.25950","article-title":"Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management","volume":"95","author":"Chien","year":"2020","journal-title":"Am. J. Hematol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1182\/blood-2012-03-420489","article-title":"Revised international prognostic scoring system for myelodysplastic syndromes","volume":"120","author":"Greenberg","year":"2012","journal-title":"Blood"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1182\/blood.V89.6.2079","article-title":"International scoring system for evaluating prognosis in myelodysplastic syndromes","volume":"89","author":"Greenberg","year":"1997","journal-title":"Blood"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41408-019-0223-7","article-title":"Lymphopenia at diagnosis is highly prevalent in myelodysplastic syndromes and has an independent negative prognostic value in IPSS-R-low-risk patients","volume":"9","author":"Silzle","year":"2019","journal-title":"Blood Cancer J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4149\/BLL_2020_068","article-title":"Does the platelet-to-lymphocyte ratio have a prognostic effect in patients with myelodysplastic syndrome?","volume":"121","author":"Yikilmaz","year":"2020","journal-title":"Bratisl. Med. J. Bratisl. Lek. Listy"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/ajh.21618","article-title":"Host immunity affects survival in myelodysplastic syndromes: Independent prognostic value of the absolute lymphocyte count","volume":"85","author":"Jacobs","year":"2010","journal-title":"Am. J. Hematol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e550","DOI":"10.1038\/bcj.2017.30","article-title":"Prognostic relevance of lymphocytopenia, monocytopenia and lymphocyte-to-monocyte ratio in primary myelodysplastic syndromes: A single center experience in 889 patients","volume":"7","author":"Saeed","year":"2017","journal-title":"Blood Cancer J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5534","DOI":"10.1182\/blood.V128.22.5534.5534","article-title":"Subnormal Lymphocyte Count Predicts Inferior Survival in Myelodysplastic Syndromes: A Single Center Experience in 889 Patients","volume":"128","author":"Saeed","year":"2016","journal-title":"Blood"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ajh.23661","article-title":"Prediction of adverse events during intensive induction chemotherapy for acute myeloid leukemia or high-grade myelodysplastic syndromes","volume":"89","author":"Buckley","year":"2014","journal-title":"Am. J. Hematol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/leu.2015.23","article-title":"Low platelet count reduces subsequent complete remission rate despite marrow with <5% blasts after AML induction therapy","volume":"29","author":"Chen","year":"2015","journal-title":"Leukemia"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1038\/bcj.2016.50","article-title":"Acute myeloid leukemia: A comprehensive review and 2016 update","volume":"6","year":"2016","journal-title":"Blood Cancer J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/ajh.25214","article-title":"Acute myeloid leukemia: 2019 update on risk-stratification and management","volume":"93","author":"Estey","year":"2018","journal-title":"Am. J. Hematol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1200\/JCO.2012.43.4738","article-title":"Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia","volume":"30","author":"Marcucci","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e4139","DOI":"10.7717\/peerj.4139","article-title":"Pretreatment platelet count predicts survival outcome of patients with de novo non-M3 acute myeloid leukemia","volume":"5","author":"Zhang","year":"2017","journal-title":"PeerJ"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Huang, J., Zhao, H., Hong, M., Zhu, H., Zhu, Y., Lian, Y., Li, S., Li, J., and Qian, S. (2018). Early recovery of the platelet count after decitabine-based induction chemotherapy is a prognostic marker of superior response in elderly patients with newly diagnosed acute myeloid leukaemia. Bmc Cancer, 18.","DOI":"10.1186\/s12885-018-5160-5"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000500230","article-title":"Low Platelet Counts at Diagnosis Predict Better Survival for Patients with Intermediate-Risk Acute Myeloid Leukemia","volume":"143","author":"Zhang","year":"2020","journal-title":"Acta Haematol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.3109\/10428194.2016.1166491","article-title":"Effect of initial absolute monocyte count on survival outcome of patients with de novo non-M3 acute myeloid leukemia","volume":"57","author":"Feng","year":"2016","journal-title":"Leuk. Lymphoma"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s12288-018-0976-3","article-title":"Absolute Monocyte Count is Superior than Absolute Lymphocyte Count at Day 28 as an Independent Prognostic Factor in Acute Myeloid Leukemia","volume":"35","author":"Ismail","year":"2019","journal-title":"Indian J. Hematol. Blood Transfus."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.21037\/tcr-20-2179","article-title":"Neutrophil-to-lymphocyte ratio correlates with prognosis and response to chemotherapy in patients with non-M3 de novo acute myeloid leukemia","volume":"10","author":"Zhang","year":"2021","journal-title":"Transl. Cancer Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1182\/blood-2018-99-112204","article-title":"Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Relapsed\/Refractory Acute Myeloid Leukemia","volume":"132","author":"Mushtaq","year":"2018","journal-title":"Blood"},{"key":"ref_86","first-page":"5087","article-title":"Absolute Lymphocyte Count after First Induction Is Associated with Relapse Free Survival in Acute Myeloid Leukemia","volume":"130","author":"Lobanova","year":"2017","journal-title":"Blood"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1182\/blood-2019-128027","article-title":"Peripheral Blood Absolute Lymphocyte Count at Diagnosis As a New Prognostic Factor in Acute Myeloid Leukemia with t(8;21) Patients","volume":"134","author":"Jang","year":"2019","journal-title":"Blood"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3109\/10428194.2013.813504","article-title":"Initial absolute lymphocyte count as a prognostic factor for outcome in acute myeloid leukemia","volume":"55","author":"Bertoli","year":"2014","journal-title":"Leuk. Lymphoma"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.3109\/10428194.2015.1020060","article-title":"Elevated lymphocyte count at time of acute myeloid leukemia diagnosis is associated with shorter remission","volume":"56","author":"Bar","year":"2015","journal-title":"Leuk. Lymphoma"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1182\/blood.V120.21.3553.3553","article-title":"Early Absolute Lymphocyte Count Is a Strong Predictor of Long-Term Improved Survival in Childhood Acute Myeloid Leukaemia","volume":"120","author":"Keenan","year":"2012","journal-title":"Blood"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1182\/blood.V124.21.5256.5256","article-title":"Impact of Day 28 Absolute Lymphocyte Count on Outcome of Adult Patients with Acute Myeloid Leukemia","volume":"124","author":"Bumma","year":"2014","journal-title":"Blood"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3747\/co.26.5033","article-title":"A general practitioner\u2019s guide to hematopoietic stem-cell transplantation","volume":"26","author":"Bazinet","year":"2019","journal-title":"Curr. Oncol. Tor. Ont"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41375-020-0776-2","article-title":"European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia","volume":"34","author":"Hochhaus","year":"2020","journal-title":"Leukemia"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/ajh.26349","article-title":"2021 Update on Allogeneic Hematopoietic Stem Cell Transplant for Myelofibrosis: A Review of Current Data and Applications on risk Stratification and Management","volume":"96","author":"Ali","year":"2021","journal-title":"Am. J. Hematol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1182\/blood-2019-03-900860","article-title":"Stem cell transplant in MF: It\u2019s time to personalize","volume":"133","author":"Passamonti","year":"2019","journal-title":"Blood"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41409-021-01472-x","article-title":"Outcomes and toxicity of allogeneic hematopoietic cell transplantation in chronic myeloid leukemia patients previously treated with second-generation tyrosine kinase inhibitors: A prospective non-interventional study from the Chronic Malignancy Working Party of the EBMT","volume":"57","author":"Olavarria","year":"2022","journal-title":"Bone Marrow Transplant."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/bjh.17612","article-title":"British Society for Haematology guidelines for the management of adult myelodysplastic syndromes","volume":"194","author":"Killick","year":"2021","journal-title":"Br. J. Haematol."},{"key":"ref_98","first-page":"38","article-title":"Acute Myeloid Leukemia: A Review","volume":"103","author":"Pelcovits","year":"2020","journal-title":"Rhode Isl. Med. J."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/bjh.17151","article-title":"Bone marrow transplantation in the United Kingdom\u2014Past, present and future","volume":"191","author":"Barrett","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/bmt.2015.351","article-title":"Risk factors and outcome of graft failure after HLA matched and mismatched unrelated donor hematopoietic stem cell transplantation: A study on behalf of SFGM-TC and SFHI","volume":"51","author":"Cluzeau","year":"2016","journal-title":"Bone Marrow Transplant."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.3389\/fonc.2019.01217","article-title":"The Graft-Versus-Leukemia Effect in AML","volume":"9","author":"Sweeney","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.bbmt.2011.08.007","article-title":"Peripheral Blood Lymphocyte and Monocyte Recovery and Survival in Acute Leukemia Postmyeloablative Allogeneic Hematopoietic Stem Cell Transplant","volume":"18","author":"Thoma","year":"2012","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.leukres.2018.04.006","article-title":"Effect of absolute monocyte count post-transplant on the outcome of patients with acute myeloid leukemia undergoing myeloablative allogeneic hematopoietic stem cell transplant with busulfan and cyclophosphamide conditioning","volume":"69","author":"Tang","year":"2018","journal-title":"Leuk. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.3109\/10428194.2013.783912","article-title":"Early lymphocyte recovery predicts superior overall survival after unmanipulated haploidentical blood and marrow transplant for myelodysplastic syndrome and acute myeloid leukemia evolving from myelodysplastic syndrome","volume":"54","author":"Chang","year":"2013","journal-title":"Leuk. Lymphoma"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbmt.2015.10.020","article-title":"Optimal Threshold and Time of Absolute Lymphocyte Count Assessment for Outcome Prediction after Bone Marrow Transplantation","volume":"22","author":"Bayraktar","year":"2016","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/sj.bmt.1704082","article-title":"Early lymphocyte recovery is an important determinant of outcome following allogeneic transplantation with CD34+selected graft and limited T-cell addback","volume":"32","author":"Chakrabarti","year":"2003","journal-title":"Bone Marrow Transplant."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/ctr.12771","article-title":"Early lymphocyte recovery predicts superior outcomes after unmanipulated haploidentical blood and marrow transplant for acute myeloid leukemia","volume":"30","author":"Fu","year":"2016","journal-title":"Clin. Transplant."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/bmt.2014.284","article-title":"Low blood lymphocyte count at 30 days post transplant predicts worse acute GVHD and survival but not relapse in a large retrospective cohort","volume":"50","author":"Gul","year":"2015","journal-title":"Bone Marrow Transplant."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3349\/ymj.2013.54.1.62","article-title":"Implication of Early Lymphocyte Recovery after Allogeneic Hematopoietic Stem Cell Transplantation in Children with Leukemia","volume":"54","author":"Han","year":"2013","journal-title":"Yonsei Med. J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/sj.leu.2402503","article-title":"Early lymphocyte recovery is a predictive factor for prolonged survival after autologous hematopoietic stem cell transplantation for acute myelogenous leukemia","volume":"16","author":"Porrata","year":"2002","journal-title":"Leukemia"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.bbmt.2016.04.015","article-title":"Higher Early Monocyte and Total Lymphocyte Counts Are Associated with Better Overall Survival after Standard Total Body Irradiation, Cyclophosphamide, and Fludarabine Reduced-Intensity Conditioning Double Umbilical Cord Blood Allogeneic Stem Cell Transplantation in Adults","volume":"22","author":"Peterlin","year":"2016","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-immunol-102119-073227","article-title":"Current Concepts and Advances in Graft-Versus-Host Disease Immunology","volume":"39","author":"Hill","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00277-017-2939-4","article-title":"Improved prognostic stratification power of CIBMTR risk score with the addition of absolute lymphocyte and eosinophil counts at the onset of chronic GVHD","volume":"96","author":"Moon","year":"2017","journal-title":"Ann. Hematol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3389\/fonc.2019.00623","article-title":"Differential Interaction of Peripheral Blood Lymphocyte Counts (ALC) With Different in vivo Depletion Strategies in Predicting Outcomes of Allogeneic Transplant: An International 2 Center Experience","volume":"9","author":"Sheth","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbmt.2017.08.029","article-title":"Optimizing Antithymocyte Globulin Dosing for Unrelated Donor Allogeneic Hematopoietic Cell Transplantation Based on Recipient Absolute Lymphocyte Count","volume":"24","author":"Kennedy","year":"2018","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"20406207211063784","DOI":"10.1177\/20406207211063783","article-title":"Association between preconditioning absolute lymphocyte count and transplant outcomes in patients undergoing matched unrelated donor allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning and anti-thymocyte globulin","volume":"12","author":"Seo","year":"2021","journal-title":"Ther. Adv. Hematol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00277-020-04347-1","article-title":"High lymphocyte counts before antithymocyte globulin administration predict acute graft-versus-host disease","volume":"100","author":"Shiratori","year":"2021","journal-title":"Ann. Hematol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/sj.bmt.1703262","article-title":"Effect of slow lymphocyte recovery and type of graft-versus-host disease prophylaxis on relapse after allogeneic bone marrow transplantation for acute myelogenous leukemia","volume":"28","author":"Kumar","year":"2001","journal-title":"Bone Marrow Transplant."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1182\/blood.V91.9.3481","article-title":"Identification of patients who may benefit from prophylactic immunotherapy after bone marrow transplantation for acute myeloid leukemia on the basis of lymphocyte recovery early after transplantation","volume":"91","author":"Powles","year":"1998","journal-title":"Blood"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/ejh.12338","article-title":"Early lymphocyte recovery at 28 d post-transplant is predictive of reduced risk of relapse in patients with acute myeloid leukemia transplanted with peripheral blood stem cell grafts","volume":"93","author":"Michelis","year":"2014","journal-title":"Eur. J. Haematol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/bmt.2009.91","article-title":"Early lymphocyte recovery after allogeneic hematopoietic SCT is associated with significant GVL effect in pediatric ALL but not acute myelogenous leukemia-Update study","volume":"44","author":"Afzal","year":"2009","journal-title":"Bone Marrow Transplant."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2141.1987.00295.x-i1","article-title":"Rapid reappearance of large granular lymphocytes (LGL) with concomitant reconstitution of natural killer (NK) activity after human bone marrow transplantation (BMT)","volume":"65","author":"Niederwieser","year":"1987","journal-title":"Br. J. Haematol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002770050246","article-title":"Association of natural killer cell immune recovery with a graft-versus-leukemia effect independent of graft-versus-host disease following allogeneic bone marrow transplantation","volume":"74","author":"Jiang","year":"1997","journal-title":"Ann. Hematol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/pbc.25347","article-title":"Impact of Very Early CD4(+)\/CD8(+) T Cell Counts on the Occurrence of Acute Graft-Versus-Host Disease and NK Cell Counts on Outcome After Pediatric Allogeneic Hematopoietic Stem Cell Transplantation","volume":"62","author":"Huttunen","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/j.bbmt.2016.09.006","article-title":"Early Natural Killer Cell Reconstitution Predicts Overall Survival in T Cell-Replete Allogeneic Hematopoietic Stem Cell Transplantation","volume":"22","author":"Minculescu","year":"2016","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.2174\/138161212799504731","article-title":"Inflammation-induced thrombosis: Mechanisms, disease associations and management","volume":"18","author":"Aksu","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/jth.13911","article-title":"Inflammation and thrombosis: Roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis","volume":"16","author":"Iba","year":"2018","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1016\/j.semcancer.2015.03.004","article-title":"Immune evasion in cancer: Mechanistic basis and therapeutic strategies","volume":"35","author":"Vinay","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s40425-019-0549-5","article-title":"Lymphopenia in Cancer Patients and its Effects on Response to Immunotherapy: An opportunity for combination with Cytokines?","volume":"7","author":"Blay","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nrc3245","article-title":"The immune contexture in human tumours: Impact on clinical outcome","volume":"12","author":"Fridman","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1182\/blood.V112.11.3633.3633","article-title":"Low Absolute Lymphocyte Count (ALC) at Diagnosis Is An IPSS-Independent Predictor of Poorer Survival in Myelodysplastic Syndromes (MDS)","volume":"112","author":"Jacobs","year":"2008","journal-title":"Blood"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1080\/21505594.2016.1208866","article-title":"Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection","volume":"7","author":"Mehta","year":"2016","journal-title":"Virulence"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/10\/2493\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:54:35Z","timestamp":1760144075000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/10\/2493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,14]]},"references-count":132,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["diagnostics12102493"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12102493","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,14]]}}}