{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:42:08Z","timestamp":1789684928781,"version":"4.0.1"},"reference-count":68,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T00:00:00Z","timestamp":1665792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Atherosclerosis is the basis of the cardiovascular continuum in peripheral artery disease (PAD) patients. Limiting functional decline and increasing quality of life are the main objectives for these patients. We conducted a prospective cohort study on 101 patients with PAD admitted to a single center in Northeast Romania. We used an index score to evaluate the 10-year mortality risk assessment and based on the scores we divided the patients into two groups: a low and low-intermediate risk mortality group (49 cases, 48.5%) and a high-intermediate and high-risk mortality group (52 cases, 51.5%). We analyzed demographics, comorbidities, clinical and paraclinical parameters and we aimed to identify the parameters associated with an unfavorable prognosis. Patients in the high-intermediate and high-risk mortality group were associated more with cardiovascular risk factors. Hypertension (p = 0.046), dyslipidemia (p &lt; 0.001), diabetes mellitus (p &lt; 0.001), and tobacco use (p = 0.018) were statistically significant factors. Lipid profile (low-density lipoprotein cholesterol, p = 0.005) and fasting blood glucose (p = 0.013) had higher mean serum values in the high-intermediate and high-risk mortality group, with a positive correlation between them and the ankle-brachial index value (p = 0.003). A multidisciplinary assessment and, especially, correction of associated cardiovascular risk factors prevent complications, and thus, improve the prognosis in the medium and long term.<\/jats:p>","DOI":"10.3390\/diagnostics12102499","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:04:55Z","timestamp":1665965095000},"page":"2499","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mortality Risk Assessment in Peripheral Arterial Disease\u2014The Burden of Cardiovascular Risk Factors over the Years: A Single Center\u2019s Experience"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2762-0918","authenticated-orcid":false,"given":"Viviana","family":"Aursulesei Onofrei","sequence":"first","affiliation":[{"name":"\u201cSt. Spiridon\u201d Clinical Emergency Hospital, Independence Boulevard nr 1, 700111 Iasi, Romania"},{"name":"Department of Medical Specialties I, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0043-9051","authenticated-orcid":false,"given":"Alexandr","family":"Ceasovschih","sequence":"additional","affiliation":[{"name":"\u201cSt. Spiridon\u201d Clinical Emergency Hospital, Independence Boulevard nr 1, 700111 Iasi, Romania"},{"name":"Department of Medical Specialties I, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2334-9953","authenticated-orcid":false,"given":"Dragos Traian Marius","family":"Marcu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7313-3320","authenticated-orcid":false,"given":"Cristina Andreea","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"},{"name":"Clinical Rehabilitation Hospital, Cardiovascular Rehabilitation Clinic, Pantelimon Halipa Street nr 14, 700661 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-8565","authenticated-orcid":false,"given":"Ovidiu","family":"Mitu","sequence":"additional","affiliation":[{"name":"\u201cSt. Spiridon\u201d Clinical Emergency Hospital, Independence Boulevard nr 1, 700111 Iasi, Romania"},{"name":"Department of Medical Specialties I, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1801-9327","authenticated-orcid":false,"given":"Florin","family":"Mitu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties I, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street nr 16, 700115 Ia\u015fi, Romania"},{"name":"Clinical Rehabilitation Hospital, Cardiovascular Rehabilitation Clinic, Pantelimon Halipa Street nr 14, 700661 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.amjmed.2019.04.043","article-title":"Peripheral Artery Disease: Past, Present, and Future","volume":"132","author":"Campia","year":"2019","journal-title":"Am. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2147\/vhrm.2007.3.2.229","article-title":"Epidemiology, Classification, and Modifiable Risk Factors of Peripheral Arterial Disease","volume":"3","author":"Shammas","year":"2007","journal-title":"Vasc. 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