{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:10:53Z","timestamp":1790223053031,"version":"4.1.0"},"reference-count":17,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"OPOS Foundation"},{"name":"Alfred-Vogt-Foundation"},{"name":"Nachwuchsfoerderung University of Basel"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Deep optic disc drusen (ODD) are located below Bruch\u2019s membrane opening (BMO) and may go undetected due to the challenges in imaging them. The purpose of this study is a head-to-head comparison of currently widely used imaging technologies: swept-source optical coherence tomography (SS-OCT; DRI OCT-1 Triton, Topcon) and enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT; Spectralis OCT, Heidelberg Engineering) for the detection of deep ODD and associated imaging features. The eyes included in this study had undergone high-resolution imaging via both EDI SD-OCT and SS-OCT volume scans, which showed at least one deep ODD or a hyperreflective line (HL). Grading was performed by three graders in a masked fashion. The study findings are based on 46 B-scan stacks of 23 eyes including a total of 7981 scans. For scan images with ODD located above or below the level of BMO, no significant difference was found between the two modalities compared in this study. However, for HLs and other features, EDI SD-OCT scan images had better visualization and less artifacts. Although SS-OCT offers deep tissue visualization, it did not appear to offer any advantage in ODD detection over a dense volume scan via EDI SD-OCT with B-scan averaging.<\/jats:p>","DOI":"10.3390\/diagnostics12102515","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T05:08:02Z","timestamp":1665983282000},"page":"2515","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of Spectral-Domain OCT versus Swept-Source OCT for the Detection of Deep Optic Disc Drusen"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5223-6483","authenticated-orcid":false,"given":"Simon P.","family":"Rothenbuehler","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen, 2600 Glostrup, Denmark"},{"name":"Department of Ophthalmology, OCTlab, University Hospital Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Malmqvist","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen, 2600 Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5855-4733","authenticated-orcid":false,"given":"Mohamed","family":"Belmouhand","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen, 2600 Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6620-6242","authenticated-orcid":false,"given":"Jakob","family":"Bjerager","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen, 2600 Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Maloca","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, OCTlab, University Hospital Basel, 4031 Basel, Switzerland"},{"name":"Institute of Molecular and Clinical Ophthalmology Basel (IOB), 4031 Basel, Switzerland"},{"name":"Moorfields Eye Hospital NHS Foundation Trust, London EC1V 2PD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-5891","authenticated-orcid":false,"given":"Michael","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen, 2600 Glostrup, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Hamann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen, 2600 Glostrup, Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/aos.13748","article-title":"Optic Disc Drusen: Understanding an Old Problem from a New Perspective","volume":"96","author":"Hamann","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/WNO.0b013e318252561b","article-title":"Differentiation of Optic Disc Edema from Optic Nerve Head Drusen with Spectral-Domain Optical Coherence Tomography","volume":"32","author":"Sarac","year":"2012","journal-title":"J. Neuro-Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.ajo.2005.01.020","article-title":"The Rate of Visual Field Loss in Optic Nerve Head Drusen","volume":"139","author":"Lee","year":"2005","journal-title":"Am. J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/WNO.0000000000000325","article-title":"Peripapillary Retinal Nerve Fiber Layer Thickness Corresponds to Drusen Location and Extent of Visual Field Defects in Superficial and Buried Optic Disc Drusen","volume":"36","author":"Malmqvist","year":"2016","journal-title":"J. Neuro-Ophthalmol."},{"key":"ref_5","first-page":"1","article-title":"Drusen of the Optic Disk. A Clinical and Genetic Study","volume":"90","author":"Lorentzen","year":"1966","journal-title":"Acta Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ajo.2020.03.052","article-title":"Young Adults With Anterior Ischemic Optic Neuropathy: A Multicenter Optic Disc Drusen Study","volume":"217","author":"Hamann","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.survophthal.2016.03.007","article-title":"Optic Disk Drusen in Children","volume":"61","author":"Chang","year":"2016","journal-title":"Surv. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.ophtha.2012.12.035","article-title":"Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen","volume":"120","author":"Merchant","year":"2013","journal-title":"Ophthalmology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/archopht.117.8.1045","article-title":"A Comparison of Imaging Techniques for Diagnosing Drusen of the Optic Nerve Head","volume":"117","author":"Landau","year":"1999","journal-title":"Arch. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01658107.2020.1810286","article-title":"The Optic Disc Drusen Studies Consortium Diagnosing Optic Disc Drusen in the Modern Imaging Era: A Practical Approach","volume":"45","author":"Costello","year":"2021","journal-title":"Neuro-Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ajo.2008.05.032","article-title":"Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography","volume":"146","author":"Spaide","year":"2008","journal-title":"Am. J. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/WNO.0000000000000585","article-title":"The Optic Disc Drusen Studies Consortium Recommendations for Diagnosis of Optic Disc Drusen Using Optical Coherence Tomography","volume":"38","author":"Malmqvist","year":"2018","journal-title":"J. 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Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0039-6257(02)00357-0","article-title":"Optic Disk Drusen","volume":"47","author":"Staubach","year":"2002","journal-title":"Surv. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/WNO.0000000000000911","article-title":"Progression Over 5 Years of Prelaminar Hyperreflective Lines to Optic Disc Drusen in the Copenhagen Child Cohort 2000 Eye Study","volume":"40","author":"Malmqvist","year":"2020","journal-title":"J. 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