{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:53:40Z","timestamp":1783652020686,"version":"3.55.0"},"reference-count":18,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The aim of this study was to compare the mortality rates, re-intervention rates, and volumetric changes in aortas following surgery, in terms of the true lumen and false lumen changes, using conventional hemi-arch repair (CET) and frozen elephant trunk (FET) techniques. During the period from 2015 to 2018, 66 patients underwent surgical treatment for acute aortic dissection (Debakey type 1). Demographic and procedure-related data were evaluated. We measured volumetric change before surgical treatment, at discharge, and at 12- and 24-month time points based on computed tomography angiography. The study cohort was divided into two groups (FET vs. CET). The mean age of the patients was 56.9 \u00b1 9.4 years in the FET group versus 63.6 \u00b1 11 years in the CET group (p = 0.063). The mean follow-up time was 24 \u00b1 6 and 25 \u00b1 5 months for the FET and CET groups, respectively. There were no significant differences between the two groups in terms of the medical histories of the cohorts. The results showed a significant increase in true lumen volume after the FET procedure (within 24 months postoperatively; p = 0.005), and no significant changes in total (p = 0.392) or false lumen (p = 0.659) volumes were noted. After the CET procedure, there were significant increases in total and false lumen volumes (p = 0.013, p = 0.042), while no significant change in true lumen was observed (p = 0.219). The volume increase in true lumen after the FET procedure was higher compared to the CET group at all postoperative time points (at discharge, 12 months, and 24 months) without significant evidence (p = 0.416, p = 0.422, p = 0.268). At two years, the volume increase in false lumen was significantly higher among the CET group compared to the FET group (p = 0.02). The Kaplan\u2013Meier curve analysis showed that patients who underwent the CET procedure underwent significantly more re-interventions due to false lumen expansion of the descending aorta (p = 0.047). Present study results indicate that the true and false lumen changes in the aorta following the FET and CET procedures were different. FET led to a significant increase in true lumen volume, while false lumen volume remained stable; however, after the CET procedure, significant false lumen enlargement was noted at mid-term follow-up time points. The re-intervention rate after CET was higher due to false lumen expansion.<\/jats:p>","DOI":"10.3390\/diagnostics12102524","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:31:01Z","timestamp":1666053061000},"page":"2524","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Volume Changes in the Descending Aorta after Frozen Elephant Trunk and Conventional Hemi-Arch Repair after Acute Type A Aortic Dissection"],"prefix":"10.3390","volume":"12","author":[{"given":"Abdulhakim","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Motekallemi","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Yahia","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6322-7152","authenticated-orcid":false,"given":"Alexander","family":"Oberhuber","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Eierhoff","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2643-2621","authenticated-orcid":false,"given":"Elena","family":"Marchiori","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0869-1630","authenticated-orcid":false,"given":"Andreas","family":"Rukosujew","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jtcvs.2012.07.013","article-title":"Supracoronary ascending aortic replacement in patients with acute aortic dissection type A: What happens to the aortic root in the long run?","volume":"146","author":"Rylski","year":"2013","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.athoracsur.2011.06.027","article-title":"The frozen elephant trunk for the treatment of chronic dissection of the thoracic aorta: A multicenter experience","volume":"92","author":"Pacini","year":"2011","journal-title":"Ann. Thorac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1093\/ejcts\/ezv415","article-title":"Open thoracoabdominal aortic aneurysm repair in the modern era: Results from a 20-year single-centre experience","volume":"49","author":"Murana","year":"2016","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/1538574415624767","article-title":"A Meta-Analysis of Total Arch Replacement with Frozen Elephant Trunk in Acute Type A Aortic Dissection","volume":"50","author":"Takagi","year":"2016","journal-title":"Vasc. Endovascular. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/ejcts\/ezx218","article-title":"Single-centre experience with the frozen elephant trunk technique in 251 patients over 15\u2009years","volume":"52","author":"Shrestha","year":"2017","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.21037\/jtd-20-2356","article-title":"Quantification of volume changes in the descending aorta after frozen elephant trunk procedure using the Thoraflex hybrid prosthesis for type A aortic dissection","volume":"13","author":"Usai","year":"2020","journal-title":"J. Thorac. Dis"},{"key":"ref_7","first-page":"631","article-title":"La tecnica del \u201cfrozen elephant trunk\u201d nel trattamento delle lesioni complesse dell\u2019aorta toracica [The frozen elephant trunk technique for the treatment of complex lesions of the thoracic aorta]","volume":"18","author":"Pacini","year":"2017","journal-title":"G. Ital. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/ejcts\/ezv085","article-title":"Current status and recommendations for use of the frozen elephant trunk technique: A position paper by the Vascular Domain of EACTS","volume":"47","author":"Shrestha","year":"2015","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/ejcts\/ezs296","article-title":"Total aortic arch replacement with a novel four-branched frozen elephant trunk graft: First-in-man results","volume":"43","author":"Shrestha","year":"2013","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_10","first-page":"606","article-title":"Early- and medium-term results after aortic arch replacement with frozen elephant trunk techniques-a single center study","volume":"2","author":"Leontyev","year":"2013","journal-title":"Ann. Cardiothorac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jacc.2013.12.028","article-title":"How does the ascending aorta geometry change when it dissects?","volume":"63","author":"Rylski","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/ejcts\/ezv045","article-title":"Aortic remodelling in aortic dissection after frozen elephant trunk","volume":"49","author":"Dohle","year":"2016","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/ejcts\/ezu173","article-title":"The frozen elephant trunk technique for acute type A aortic dissection: Results from 15 years of experience","volume":"47","author":"Katayama","year":"2015","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.athoracsur.2009.06.055","article-title":"Long-term results after repair of type A acute aortic dissection according to false lumen patency","volume":"88","author":"Fattouch","year":"2009","journal-title":"Ann. Thorac. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12055-018-0679-2","article-title":"Aortic remodeling in acute type A aortic dissection after frozen elephant trunk implantation","volume":"35","author":"Pacini","year":"2019","journal-title":"Indian J. Thorac. Cardiovasc. Surg."},{"key":"ref_16","first-page":"1066","article-title":"Frozen elephant trunk technique and partial remodeling for acute type A aortic dissection","volume":"40","author":"Uchida","year":"2011","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.5090\/jcs.21.027","article-title":"Distal Aortic Remodeling after Type A Dissection Repair: An Ongoing Mirage","volume":"54","author":"Rathore","year":"2021","journal-title":"J. Chest. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.athoracsur.2021.07.099","article-title":"Inside Pathophysiology of Thoracic Aorta Grafts","volume":"114","author":"Manenti","year":"2022","journal-title":"Ann. Thorac. Surg."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/10\/2524\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:56:07Z","timestamp":1760144167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/10\/2524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,18]]},"references-count":18,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["diagnostics12102524"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12102524","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,18]]}}}