{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T03:04:48Z","timestamp":1760151888054,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Eligibility criteria for blood donation require hemoglobin levels of \u226512.5 g\/dL for women and \u226513.5 g\/dL for men, and a platelet count of \u2265180 \u00d7 109\/L. Screening methods before donation should ensure high accuracy, precision, and ease in operation. We assessed the performance, precision, and repeatability of the Horiba Micros ES 60 (Horiba) compared to the Beckman Coulter DXH 800. Methods: Performance was compared by testing samples for each of the 11 devices across 6 sites in the Transfusion Service of Friuli Venezia Giulia Region, Italy. We measured precision by calculating the coefficient of variation (CV), concordance with \u03c1-Pearson\u2019s correlation coefficient, and accuracy with F-tests. The intra-assay agreement was examined in the 11 devices, and repeatability was performed by using CV and the Kruskal\u2013Wallis test. Results: The precision of Horiba was acceptable. Overall, \u03c1-Pearson\u2019s coefficients indicated a strong correlation and positive relationship between all variables. The Bland\u2013Altman plots showed that most of the differences lay within the limits of agreement. All CV were below the reference threshold for all the parameters. Finally, the Kruskal\u2013Wallis test reported non-significant statistical differences for all parameters, except platelet count (p &lt; 0.000). Conclusions: Horiba is adequate for routine pre-donation screening. The intra-assay agreement further demonstrates the accuracy of the device.<\/jats:p>","DOI":"10.3390\/diagnostics12112586","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T12:29:45Z","timestamp":1666700985000},"page":"2586","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Horiba Micros ES 60 Blood Cell Analyzer in Blood Donor Eligibility: A Validation Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Silvia","family":"Tillati","sequence":"first","affiliation":[{"name":"Unit of Medical Statistics, Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4846-2338","authenticated-orcid":false,"given":"Ilaria","family":"Pati","sequence":"additional","affiliation":[{"name":"National Blood Centre, Italian National Institute of Health, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Delle Donne","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Department, Udine University Hospital, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Meneghel","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Department, Udine University Hospital, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0583-4958","authenticated-orcid":false,"given":"Donatella","family":"Londero","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Department, Udine University Hospital, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"De Angelis","sequence":"additional","affiliation":[{"name":"National Blood Centre, Italian National Institute of Health, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1016\/S0140-6736(17)31928-1","article-title":"Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): A randomized trial of 45,000 donors","volume":"390","author":"Thompson","year":"2017","journal-title":"Lancet"},{"key":"ref_2","unstructured":"EDQM (2020). 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Res."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/11\/2586\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:02:24Z","timestamp":1760144544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/12\/11\/2586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,25]]},"references-count":20,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["diagnostics12112586"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics12112586","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2022,10,25]]}}}