{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:34:46Z","timestamp":1760243686523,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Caesarean section is associated with an increased risk of abnormal placental implantation and adverse pregnancy outcomes in subsequent pregnancies. Besides the placenta accrete spectrum, only a few of the previous studies focused on other placental development alterations in the scarred uterus. We assessed placental development deviations in the uterus with a Caesarean section scar by evaluating placental volume (PV) and vascular flow indexes. From 1 January 2021 until 31 March 2022, placental volumes and vascularization indexes (VI, FI, VFI) were prospectively measured by 3D power Doppler and VOCAL techniques in 221 patients attending the first trimester screening program. We also calculated the placental quotient to standardize PV to the gestational age. No statistically significant differences in the values of placental volume, placental quotient and placental vascularization indexes were detected between women with previous Caesarean section delivery or women with vaginal delivery. FI was significantly lower in nulliparous in the first trimester. The results of our study suggest that 3D placental evaluation was not able to detect placental development alteration in the uterus with a Caesarean section scar. Future research needs to verify whether 3D power Doppler and Vocal techniques can provide more information if used in an earlier gestational age.<\/jats:p>","DOI":"10.3390\/diagnostics12112674","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T03:28:10Z","timestamp":1667532490000},"page":"2674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does a Caesarean Section Scar Affect Placental Volume, Vascularity and Localization?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-4960","authenticated-orcid":false,"given":"Diana","family":"Boku\u010dava","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, R\u012bga Stradi\u0146\u0161 University, LV-1007 R\u012bga, Latvia"},{"name":"R\u012bga Maternity Hospital, LV-1013 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-1187","authenticated-orcid":false,"given":"Anda","family":"\u0136\u012bv\u012bte-Urt\u0101ne","sequence":"additional","affiliation":[{"name":"Institute of Public Health, R\u012bga Stradi\u0146\u0161 University, LV-1007 R\u012bga, Latvia"},{"name":"Department of Public Health and Epidemiology, R\u012bga Stradi\u0146\u0161 University, LV-1010 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavels","family":"Doma\u0161evs","sequence":"additional","affiliation":[{"name":"R\u012bga Maternity Hospital, LV-1013 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5239-5134","authenticated-orcid":false,"given":"Laura","family":"L\u016bse","sequence":"additional","affiliation":[{"name":"R\u012bga Maternity Hospital, LV-1013 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u0101lija","family":"Vedmedovska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, R\u012bga Stradi\u0146\u0161 University, LV-1007 R\u012bga, Latvia"},{"name":"R\u012bga Maternity Hospital, LV-1013 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-6254","authenticated-orcid":false,"given":"Gilbert G. G.","family":"Donders","sequence":"additional","affiliation":[{"name":"Department of Obstetics and Gynecology, Antwerp University Hospital, 2650 Antwerp, Belgium"},{"name":"Femicare VZW, Clinical Research for Women, 3300 Tienen, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e005671","DOI":"10.1136\/bmjgh-2021-005671","article-title":"Trends and projections of caesarean section rates: Global and regional estimates","volume":"6","author":"Betran","year":"2021","journal-title":"BMJ Glob. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/ijgo.12408","article-title":"FIGO consensus guidelines on placenta accreta spectrum disorders: Prenatal diagnosis and screening","volume":"140","author":"Jauniaux","year":"2018","journal-title":"Int. J. Gynaecol. 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