{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:34:46Z","timestamp":1760243686984,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Romanian Ministry of Education and Research, CNCS","award":["Ctr. No. PD87\/2020","Ctr. No. 393PED\/2020","Ctr. 18\/N\/2019","18PFE\/30.12.2021"],"award-info":[{"award-number":["Ctr. No. PD87\/2020","Ctr. No. 393PED\/2020","Ctr. 18\/N\/2019","18PFE\/30.12.2021"]}]},{"name":"Ministry of Research and Innovation","award":["Ctr. No. PD87\/2020","Ctr. No. 393PED\/2020","Ctr. 18\/N\/2019","18PFE\/30.12.2021"],"award-info":[{"award-number":["Ctr. No. PD87\/2020","Ctr. No. 393PED\/2020","Ctr. 18\/N\/2019","18PFE\/30.12.2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>In this study, we explore the \u201cwhy?\u201d, and \u201chow?\u201d, monitoring the pH of the fetal scalp is used, and show its limitations. In addition, we review the development of new devices based on the modern physics and nanomaterials serving this topic. Most of the works we found in our search have focused on improving the prognostic of fetal heart rate monitoring, because it is the \u201cgolden standard\u201d in determining fetal distress. Although the best-known screening method, it can only provide limited information about the actual status of the fetus. The best predictive assessment, with the highest reproducibility, states that a normal fetal heart rate is indicative of a healthy baby. However, its excellent sensitivity is much reduced when identifying the actual \u201cdistress\u201d. This is when second-line monitoring methods come into play to guide the diagnostics and direct the obstetrician towards an action plan. Although a historic method, fetal scalp pH sampling is still under review as to its efficiency and place in the current obstetrics. Continuous surveillance of the fetal parameters is important, especially for the fetuses undergoing intrauterine growth restricted (IUGR). Since fetal scalp blood sampling is still under research and is a randomized controlled trial, which compares the relevance of pH and lactates to the obstetrical situation, the maternal-fetal medicine could greatly benefit from the introduction of engineered nanomedicines to the field.<\/jats:p>","DOI":"10.3390\/diagnostics12112675","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T03:28:10Z","timestamp":1667532490000},"page":"2675","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Current Innovative Methods of Fetal pH Monitoring\u2014A Brief Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6381-7419","authenticated-orcid":false,"given":"Roxana-Elena","family":"Bohiltea","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cCarol Davila\u201d University of Medicine and Pharmacy Bucharest, 37 Dionisie Lupu, 020021 Bucharest, Romania"},{"name":"Department of Obstetrics, Gynecology and Neonatology, Filantropia Hospital, 11-13 Ion Mihalache Blv., Sector 1, 011171 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8957-737X","authenticated-orcid":false,"given":"Bianca Margareta","family":"Mihai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Neonatology, Filantropia Hospital, 11-13 Ion Mihalache Blv., Sector 1, 011171 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioni\u021b\u0103","family":"Ducu","sequence":"additional","affiliation":[{"name":"Memorial Life Hospital, Grivitei Route, No. 365, 010719 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9345-8384","authenticated-orcid":false,"given":"Ana-Maria","family":"Cioca","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy Bucharest, 37 Dionisie Lupu, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia-Teodora","family":"Bohiltea","sequence":"additional","affiliation":[{"name":"\u00c9cole H\u00f4teli\u00e8re de Lausanne, 1000 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4705-0606","authenticated-orcid":false,"given":"Ana-Maria","family":"Iordache","sequence":"additional","affiliation":[{"name":"Optospintronics Department, National Institute for Research and Development in Optoelectronics-INOE 2000, 409 Atomistilor, 077125 Magurele, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9840-9896","authenticated-orcid":false,"given":"Stefan-Marian","family":"Iordache","sequence":"additional","affiliation":[{"name":"Optospintronics Department, National Institute for Research and Development in Optoelectronics-INOE 2000, 409 Atomistilor, 077125 Magurele, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-8001","authenticated-orcid":false,"given":"Cristiana Eugenia Ana","family":"Grigorescu","sequence":"additional","affiliation":[{"name":"Optospintronics Department, National Institute for Research and Development in Optoelectronics-INOE 2000, 409 Atomistilor, 077125 Magurele, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silviu","family":"Marinescu","sequence":"additional","affiliation":[{"name":"Department 11-Plastic and Reconstructive Surgery, Pediatric Surgery, University of Medicine and Pharmacy \u201cCarol Davila\u201d, Eroii Sanitari Bvd., No. 8, Sector 5, 050471 Bucharest, Romania"},{"name":"Discipline of Plastic Surgery and Reconstructive Microsurgery, Emergency Clinical Hospital \u201cBagdasar-Arseni\u201d, Berceni Street, No. 12, Sector 4, 041915 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Valenzuela, C., Gregory, E., and Martin, J. 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