{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:17:26Z","timestamp":1792203446840,"version":"4.4.0"},"reference-count":103,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The management of chronic diseases in the midst of the COVID-19 pandemic is especially challenging, and reducing potential psychological harm is essential. This review aims to determine the prevalence of depression during the COVID-19 pandemic in patients with chronic disease, and to characterize the impacts of related factors. A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The meta-analysis was performed using StatsDirect software. The review identified 33 articles with a total of 50,905 patients with chronic diseases. Four meta-analyses were performed to estimate the prevalence of depression. In diabetic patients, the prevalence ranged from 17% (95% CI = 7\u201331) (PHQ-9) to 33% (95% CI = 16\u201351) (PHQ-8); in obese patients, the prevalence was 48% (95% CI = 26\u201371); and in hypertensive patients, the prevalence was 18% (95% CI = 13\u201324). The factors significantly associated with depression were female sex, being single, deterioration in the clinical parameters of diabetes, a decrease in self-care behavior, reduced physical activity and sleep time and fear of contagion. The COVID-19 pandemic has significantly increased levels of depression among persons with chronic disease. Pandemics and other emergency events have a major impact on mental health, so early psychological interventions and health management policies are needed to reinforce chronic patients\u2019 physical and mental health.<\/jats:p>","DOI":"10.3390\/diagnostics12123094","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T02:50:51Z","timestamp":1670554251000},"page":"3094","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence of Depression and Related Factors among Patients with Chronic Disease during the COVID-19 Pandemic: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Rub\u00e9n A.","family":"Garc\u00eda-Lara","sequence":"first","affiliation":[{"name":"UGC Orgiva, Granada-South Health Management Area, Andalusian Health Service, Calle La Madre s\/n, Lanjar\u00f3n, 18420 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4133-0092","authenticated-orcid":false,"given":"Nora","family":"Suleiman-Martos","sequence":"additional","affiliation":[{"name":"Nursing Department, Faculty of Health Sciences, University of Granada, Av. de la Ilustraci\u00f3n, 60, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1074-1462","authenticated-orcid":false,"given":"Mar\u00eda J.","family":"Membrive-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Red Cross Nursing Center, University of Sevilla, Av. la Cruz Roja, 41009 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-9935","authenticated-orcid":false,"given":"Victoria","family":"Garc\u00eda-Morales","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Biotechnology and Public Health, Faculty of Medicine, University of Cadiz, Pl. Falla, 9, 11003 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Quesada-Caballero","sequence":"additional","affiliation":[{"name":"UGC La Caleta Granada-Metropolitano, Andalusian Health Service, Av. del Sur, 11, 18014 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6365-9070","authenticated-orcid":false,"given":"Isabel M.","family":"Guisado-Requena","sequence":"additional","affiliation":[{"name":"Nursing Department, Faculty of Health Sciences, University of Castilla la Mancha, 02006 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8684-1817","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"G\u00f3mez-Urquiza","sequence":"additional","affiliation":[{"name":"Nursing Department, Faculty of Health Sciences, University of Granada, Cortadura del Valle s\/n, 51001 Ceuta, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pandey, D., Bansal, S., Goyal, S., Garg, A., Sethi, N., Pothiyill, D.I., Sreelakshmi, E.S., Sayyad, M.G., and Sethi, R. 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