{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:40:04Z","timestamp":1780422004278,"version":"3.54.1"},"reference-count":30,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The current definition of osteoporosis includes alteration of bone quality. The assessment of bone quality is improved by the development of new texture analysis softwares. Our objectives were to assess if proximal femoral trabecular bone texture measured in Ultra high field (UHF) 7 Tesla MRI and CT scan were related to biomechanical parameters, and if the combination of texture parameters and areal bone mineral density (aBMD) measured by dual-energy X-ray absorptiometry provided a better prediction of femoral failure than aBMD alone. The aBMD of 16 proximal femur ends from eight cadavers were investigated. Nineteen textural parameters were computed in three regions or volumes of interest for each specimen on UHF MRI and CT scan. Then, the corresponding failure load and failure stress were calculated thanks to mechanical compression test. aBMD was not correlated to failure load (R2 = 0.206) and stress (R2 = 0.153). The failure load was significantly correlated with ten parameters in the greater trochanter using UHF MRI, and with one parameter in the neck and the greater trochanter using CT scan. Eight parameters in the greater trochanter using UHF MRI combined with aBMD improved the failure load prediction, and seven parameters improved the failure stress prediction. Our results suggest that textural parameters provide additional information on the fracture risk of the proximal femur when aBMD is not contributive.<\/jats:p>","DOI":"10.3390\/diagnostics12123143","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T02:59:01Z","timestamp":1670900341000},"page":"3143","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Texture Parameters Measured by UHF-MRI and CT Scan Provide Information on Bone Quality in Addition to BMD: A Biomechanical Ex Vivo Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Paul","family":"Knoepflin","sequence":"first","affiliation":[{"name":"Department of Radiology, Institute for Locomotion, Sainte-Marguerite Hospital, APHM, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5283-3504","authenticated-orcid":false,"given":"Martine","family":"Pithioux","sequence":"additional","affiliation":[{"name":"Institute of Movement Sciences (ISM), CNRS, Aix Marseille University, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bendahan","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonnance Magn\u00e9tique Biologique et M\u00e9dicale (CRMBM) UMR 7339, CNRS (Centre National de la Recherche Scientifique), Facult\u00e9 de M\u00e9decine, Aix Marseille University, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Poullain","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute for Locomotion, Sainte-Marguerite Hospital, APHM, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3035-7006","authenticated-orcid":false,"given":"Thomas","family":"Le Corroller","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute for Locomotion, Sainte-Marguerite Hospital, APHM, 13009 Marseille, France"},{"name":"Institute of Movement Sciences (ISM), CNRS, Aix Marseille University, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyprien","family":"Fabre","sequence":"additional","affiliation":[{"name":"Laboratoire de Sant\u00e9 Publique EA3279, Facult\u00e9 de M\u00e9decine, Aix Marseille University, 13005 Marseille, France"},{"name":"Service de Sant\u00e9 Publique et d\u2019Information M\u00e9dicale, H\u00f4pital de la Conception, APHM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Pauly","sequence":"additional","affiliation":[{"name":"Laboratoire de Sant\u00e9 Publique EA3279, Facult\u00e9 de M\u00e9decine, Aix Marseille University, 13005 Marseille, France"},{"name":"Service de Sant\u00e9 Publique et d\u2019Information M\u00e9dicale, H\u00f4pital de la Conception, APHM, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-9096","authenticated-orcid":false,"given":"Maud","family":"Creze","sequence":"additional","affiliation":[{"name":"Radiology Department, Bic\u00eatre Hospital, APHP, 94270 Le Kremlin\u2013Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2818-7500","authenticated-orcid":false,"given":"Enrico","family":"Soldati","sequence":"additional","affiliation":[{"name":"Institute of Movement Sciences (ISM), CNRS, Aix Marseille University, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Champsaur","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute for Locomotion, Sainte-Marguerite Hospital, APHM, 13009 Marseille, France"},{"name":"Institute of Movement Sciences (ISM), CNRS, Aix Marseille University, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Guenoun","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute for Locomotion, Sainte-Marguerite Hospital, APHM, 13009 Marseille, France"},{"name":"Institute of Movement Sciences (ISM), CNRS, Aix Marseille University, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell","year":"2006","journal-title":"Osteoporos. 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