{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:38:05Z","timestamp":1787315885158,"version":"build-2736575974"},"reference-count":40,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Scientific Foundation of the Russian Academy of Sciences","doi-asserted-by":"publisher","award":["22-15-00113"],"award-info":[{"award-number":["22-15-00113"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a debilitating chronic disease of unknown etiology, sharing a similar clinical presentation with the increasingly recognized post-COVID syndrome. We performed the first cross-sectional study of ME\/CFS in a community population in Russia. Then we described and compared some clinical and pathophysiological characteristics of ME\/CFS and post-COVID syndrome as neuroimmune disorders. Of the cohort of 76 individuals who suggested themselves as suffering from ME\/CFS, 56 were diagnosed with ME\/CFS by clinicians according to \u22651 of the four most commonly used case definitions. Of the cohort of 14 individuals with post-COVID-19 syndrome, 14 met the diagnostic criteria for ME\/CFS. The severity of anxiety\/depressive symptoms did not correlate with the severity of fatigue either in ME\/CFS or in post-COVID ME\/CFS. Still, a positive correlation was found between the severity of fatigue and 20 other symptoms of ME\/CFS related to the domains of \u201cpost-exertional exhaustion\u201d, \u201cimmune dysfunction\u201d, \u201csleep disturbances\u201d, \u201cdysfunction of the autonomic nervous system\u201d, \u201cneurological sensory\/motor disorders\u201d and \u201cpain syndromes\u201d. Immunological abnormalities were identified in 12\/12 patients with ME\/CFS according to the results of laboratory testing. The prevalence of postural orthostatic tachycardia assessed in the active orthostatic test amounted to 37.5% in ME\/CFS and 75.0% in post-COVID ME\/CFS (the latter was higher than in healthy controls, p = 0.02). There was a more pronounced increase in heart rate starting from the 6th minute of the test in post-COVID ME\/CFS compared with the control group. Assessment of the functional characteristics of microcirculation by laser doppler flowmetry revealed obvious and very similar changes in ME\/CFS and post-COVID ME\/CFS compared to the healthy controls. The identified laser doppler flowmetry pattern corresponded to the hyperemic form of microcirculation disorders usually observed in acute inflammatory response or in case of systemic vasoconstriction failure.<\/jats:p>","DOI":"10.3390\/diagnostics13010066","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T07:02:12Z","timestamp":1672124532000},"page":"66","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Ground?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6973-9901","authenticated-orcid":false,"given":"Varvara A.","family":"Ryabkova","sequence":"first","affiliation":[{"name":"Laboratory of the Mosaic of Autoimmunity and Department of Pathology, Saint Petersburg State University, 199034 Saint-Petersburg, Russia"},{"name":"Department of Hospital Therapy Named after Academician M.V. Chernorutskii, Research Institute of Rheumatology and Allergology, Pavlov First Saint Petersburg State Medical University, 197022 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Y.","family":"Gavrilova","sequence":"additional","affiliation":[{"name":"Laboratory of the Mosaic of Autoimmunity and Department of Pathology, Saint Petersburg State University, 199034 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara V.","family":"Fedotkina","sequence":"additional","affiliation":[{"name":"Laboratory of the Mosaic of Autoimmunity and Department of Pathology, Saint Petersburg State University, 199034 Saint-Petersburg, Russia"},{"name":"National Medical Research Center Named after V. A. Almazov, 197341 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6359-0026","authenticated-orcid":false,"given":"Leonid P.","family":"Churilov","sequence":"additional","affiliation":[{"name":"Laboratory of the Mosaic of Autoimmunity and Department of Pathology, Saint Petersburg State University, 199034 Saint-Petersburg, Russia"},{"name":"Saint Petersburg Research Institute of Phthisiopulmonology, 191036 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[{"name":"Laboratory of the Mosaic of Autoimmunity and Department of Pathology, Saint Petersburg State University, 199034 Saint-Petersburg, Russia"},{"name":"Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat-Gan 52621, Israel"},{"name":"Ariel University, Ariel 98603, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1515\/reveh-2015-0026","article-title":"Review of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: An evidence-based approach to diagnosis and management by clinicians","volume":"30","author":"Bested","year":"2015","journal-title":"Rev. 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