{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:55:37Z","timestamp":1774612537641,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"Ministry of Science, ICT, and Future Planning","doi-asserted-by":"publisher","award":["2020R1C1C1007169"],"award-info":[{"award-number":["2020R1C1C1007169"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Catholic University of Pusan 2021 and Brain Busan 21 Plus project","award":["2020R1C1C1007169"],"award-info":[{"award-number":["2020R1C1C1007169"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The present study aimed to clinically evaluate the effect of T-cell dysfunction in hemodialysis (HD) patients with latent tuberculosis (TB) infection (LTBI) who were false-negatives in the QuantiFERON-TB Gold In-Tube (QFT-GIT) test. Whole blood samples from a total of 20 active TB patients, 83 HD patients, and 52 healthy individuals were collected, and the QFT-GIT test was used for measuring Mycobacterium tuberculosis (MTB)-specific interferon gamma (IFN-\u03b3) level. The positive rate of the IFN-\u03b3 release assays (IGRAs) in HD patients was lower than the negative rate. The mean value of MTB-specific IFN-\u03b3 level, which determines the positive rate of the IGRA test, was highest in active TB, followed by HD patients and healthy individuals. Among HD patients, phytohemagglutinin A (PHA)-stimulated IFN-\u03b3 levels of approximately 40% were 10.00 IU\/mL or less. However, there was no low level of PHA-stimulated IFN-\u03b3 in the healthy individuals. This reveals that T-cell function in HD patients was reduced compared to healthy individuals, which leads to the possibility that QFT-GIT results in HD patients are false-negative. The clinical manifestations of TB in patients on HD are quite non-specific, making timely diagnosis difficult and delaying the initiation of curative treatment, delay being a major determinant of outcome.<\/jats:p>","DOI":"10.3390\/diagnostics13010088","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T08:42:22Z","timestamp":1672216942000},"page":"88","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predictors for False-Negative Interferon-Gamma Release Assay Results in Hemodialysis Patients with Latent Tuberculosis Infection"],"prefix":"10.3390","volume":"13","author":[{"given":"Heechul","family":"Park","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea"},{"name":"Clinical Trial Specialist Program for In Vitro Diagnostics, Brain Busan 21 Plus Program, Graduate School, Catholic University of Pusan, Busan 46252, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Jeong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea"},{"name":"Department of Laboratory Medicine, Good Samsun Hospital, Busan 47007, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9595-7355","authenticated-orcid":false,"given":"Ye Na","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kosin University Gospel Hospital, Busan 49267, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Bae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science, Masan University, Changwon 51217, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6905-5710","authenticated-orcid":false,"given":"Jaewon","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Park Clinic, Busan 46512, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ae","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Seoul 03772, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyejon","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul 03772, Republic of Korea"},{"name":"Clinical Vaccine Research Section, International Tuberculosis Research Center, Seoul 03772, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2511-6555","authenticated-orcid":false,"given":"Sunghyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea"},{"name":"Clinical Trial Specialist Program for In Vitro Diagnostics, Brain Busan 21 Plus Program, Graduate School, Catholic University of Pusan, Busan 46252, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.thorsurg.2018.09.010","article-title":"The Global Fight Against Tuberculosis","volume":"29","author":"Daley","year":"2019","journal-title":"Thorac. 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