{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:15:59Z","timestamp":1785539759783,"version":"3.56.0"},"reference-count":23,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Cor triatriatum sinister is a rare congenital heart disease characterized by an additional fibromuscular membrane in the left atrium. Cardioembolic stroke is a rare complication of cor triatriatum sinister, especially among women. We hereby describe the case of an 18-year-old female patient, without a past medical history, presenting with cardioembolic stroke in the territory of the right posterior cerebral artery. During extensive diagnostic work-up, nonrestrictive cor triatriatum sinister and patent foramen ovale were diagnosed using transthoracic and transesophageal echocardiography. In clinical practice, it is important to identify congenital cardiac defects as potential substrates for cardioembolism in young patients. In our case, cor triatriatum sinister presenting as ischemic stroke was diagnosed, which is an uncommon finding, especially in young females. Determining the optimal management strategy for patients with cor triatriatum sinister complicated by cardioembolic stroke requires a multidisciplinary approach.<\/jats:p>","DOI":"10.3390\/diagnostics13010097","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:59:01Z","timestamp":1672282741000},"page":"97","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cor Triatriatum Sinister Presenting as Cardioembolic Stroke in a Young Woman"],"prefix":"10.3390","volume":"13","author":[{"given":"Timea Magdolna","family":"Szabo","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Environmental Chemistry, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhard","family":"Heidenhoffer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical County Hospital Mures, 540103 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"Kirchmaier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical County Hospital Mures, 540103 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedek","family":"Pelok","sequence":"additional","affiliation":[{"name":"Department of Neurology, Municipal Hospital Odorheiu Secuiesc, 535600 Odorheiu Secuiesc, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3346-4082","authenticated-orcid":false,"given":"Attila","family":"Frigy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical County Hospital Mures, 540103 Targu Mures, Romania"},{"name":"Department of Internal Medicine IV, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540103 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1542\/peds.102.S1.258","article-title":"Report of the New England regional infant cardiac program, by Donald C. Fyler, MD, Pediatrics, 1980, 65(suppl):375\u2013461","volume":"102","author":"Talner","year":"1998","journal-title":"Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1177\/1089253216680495","article-title":"Cor Triatriatum: A Review","volume":"21","author":"Jha","year":"2017","journal-title":"Semin. Cardiothorac. Vasc. Anesth."},{"key":"ref_3","unstructured":"Gatzoulis, M.A., Webb, G.D., and Daubeney, P.E.F. (2017). Diagnosis and Management of Adult Congenital Heart Disease, Elsevier. [3rd ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Muggenthaler, M.M.A., Chowdhury, B., Hasan, S.N., Cross, H.E., Mark, B., Harlalka, G.V., Patton, M.A., Ishida, M., Behr, E.R., and Sharma, S. (2017). Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice. PLoS Genet., 13.","DOI":"10.1371\/journal.pgen.1006470"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ijcard.2016.02.072","article-title":"Hyaluronidase 2 deficiency is amolecular cause of cor triatriatumsinister in mice","volume":"209","author":"Chowdhury","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1074\/jbc.M112.393629","article-title":"Murine Hyaluronidase 2 Deficiency Results in Extracellular Hyaluronan Accumulation and Severe Cardiopulmonary Dysfunction","volume":"288","author":"Chowdhury","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0828-282X(10)70418-9","article-title":"Cor triatriatum sinistrum in childhood. A single institution\u2019s experience","volume":"26","author":"Humpl","year":"2010","journal-title":"Can. J. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjcr\/ytaa096","article-title":"Cardioembolic stroke in a young male with cor triatriatum sinister: A case report","volume":"4","author":"Amara","year":"2020","journal-title":"Eur. Heart J. Case Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"bcr-2017-219763","DOI":"10.1136\/bcr-2017-219763","article-title":"5th. 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Electrophysiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"815312","DOI":"10.3389\/fcvm.2021.815312","article-title":"A Rare Complication During Transcatheter Closure of Double Atrial Septal Defects With Incomplete Cor Triatriatum Dexter: A Case Report","volume":"8","author":"Chen","year":"2022","journal-title":"Front. Cardiovasc. Med."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/1\/97\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:54:59Z","timestamp":1760147699000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/1\/97"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["diagnostics13010097"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13010097","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]}}}