{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:35:03Z","timestamp":1777343703829,"version":"3.51.4"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901238"],"award-info":[{"award-number":["81901238"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017zhyx37"],"award-info":[{"award-number":["2017zhyx37"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022xjk207"],"award-info":[{"award-number":["2022xjk207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2208085MH224"],"award-info":[{"award-number":["2208085MH224"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of Institute of Translational Medicine of Anhui Province","award":["81901238"],"award-info":[{"award-number":["81901238"]}]},{"name":"Project of Institute of Translational Medicine of Anhui Province","award":["2017zhyx37"],"award-info":[{"award-number":["2017zhyx37"]}]},{"name":"Project of Institute of Translational Medicine of Anhui Province","award":["2022xjk207"],"award-info":[{"award-number":["2022xjk207"]}]},{"name":"Project of Institute of Translational Medicine of Anhui Province","award":["2208085MH224"],"award-info":[{"award-number":["2208085MH224"]}]},{"name":"Scientific Foundation of Anhui Medical University","award":["81901238"],"award-info":[{"award-number":["81901238"]}]},{"name":"Scientific Foundation of Anhui Medical University","award":["2017zhyx37"],"award-info":[{"award-number":["2017zhyx37"]}]},{"name":"Scientific Foundation of Anhui Medical University","award":["2022xjk207"],"award-info":[{"award-number":["2022xjk207"]}]},{"name":"Scientific Foundation of Anhui Medical University","award":["2208085MH224"],"award-info":[{"award-number":["2208085MH224"]}]},{"name":"National Natural Science Foundation of Anhui Province","award":["81901238"],"award-info":[{"award-number":["81901238"]}]},{"name":"National Natural Science Foundation of Anhui Province","award":["2017zhyx37"],"award-info":[{"award-number":["2017zhyx37"]}]},{"name":"National Natural Science Foundation of Anhui Province","award":["2022xjk207"],"award-info":[{"award-number":["2022xjk207"]}]},{"name":"National Natural Science Foundation of Anhui Province","award":["2208085MH224"],"award-info":[{"award-number":["2208085MH224"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Post-neurosurgical bacterial meningitis (PNBM) is one of the severe complications in patients receiving neurosurgical procedures. Recent studies have found microbe-related glycans play important roles in adhesion, invasion, and toxicity toward innate immunological reactions. In this study, we aimed to investigate the glycomic profile and its potential diagnostic efficacy in post-neurosurgical bacterial meningitis (PNBM) patients with hemorrhagic stroke. A total of 136 cerebrospinal fluid (CSF) samples were recruited and divided into a PNBM group and a non-PNBM group based on the clinical diagnostic criteria. A lectin biochip-based method was established for the detection of glycans in CSF. The clinicopathological data and biochemical parameters in CSF from all patients were analyzed. Two models for multivariate analysis investigating glycan changes in the CSF were conducted, aiming at determining the specific expression and diagnostic efficacy of lectin-probing glycans (LPGs) for PNBM. In univariate analysis, we found that 8 out of 11 LPGs were significantly correlated with PNBM. Model 1 multivariate analysis revealed that PNA (p = 0.034), Jacalin (p = 0.034) and LTL (p = 0.001) were differentially expressed in the CSF of PNBM patients compared with those of non-PNBM patients. Model 2 multivariate analysis further disclosed that LTL (p = 0.021) and CSF glucose (p &lt; 0.001) had independent diagnostic efficacies in PNBM, with areas under the curve (AUC) of 0.703 and 0.922, respectively. In summary, this study provided a new insight into the subject of CSF glycomics concerning bacterial infection in patients with hemorrhagic stroke.<\/jats:p>","DOI":"10.3390\/diagnostics13020187","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T01:33:30Z","timestamp":1672882410000},"page":"187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Value of Glycan Changes in Cerebrospinal Fluid for Evaluation of Post-Neurosurgical Bacterial Meningitis with Hemorrhagic Stroke Patients"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5079-8730","authenticated-orcid":false,"given":"Lei","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijian","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xuzhou Municipal First People\u2019s Hospital, Daxue Road 269, Xuzhou 221116, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liao","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Anhui Medical University, Meishan Road 81, Hefei 230032, China"},{"name":"School of Clinical Medicine, Anhui Medical University, Meishan Road 81, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pathology, Anhui Medical University, Meishan Road 81, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.cmi.2017.05.013","article-title":"Management of post-neurosurgical meningitis: Narrative review","volume":"23","author":"Hussein","year":"2017","journal-title":"Clin. 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