{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:23:32Z","timestamp":1789521812539,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Introduction: Urinary CD80 has been shown to have good specificity for minimal change disease (MCD) in children. However, the investigation of circulating factors such as soluble urokinase plasminogen activator receptor (suPAR) as biomarkers of focal segmental glomerulosclerosis (FSGS) is quite controversial. The objective of this study was to determine whether urinary CD80 and serum suPAR can be used for the diagnosis of MCD and FSGS, respectively, in the adult population of Brazil. We also attempted to determine whether those biomarkers assess the response to immunosuppressive treatment. Methods: This was a prospective study in which urine and blood samples were collected for analysis of CD80 and suPAR, respectively, only in the moment of renal biopsy, from patients undergoing to diagnostic renal biopsy. At and six months after biopsy, we analyzed serum creatinine, serum albumin, and proteinuria in order to evaluate the use of the CD80 and suPAR collected in diagnosis as markers of response to immunosuppressive treatment. In healthy controls were collected urinary CD80 and proteinuria, serum suPAR, and creatinine. Results: The results of 70 renal biopsies were grouped, by diagnosis, as follows: FSGS (n = 18); membranous nephropathy (n = 14); MCD (n = 5); and other glomerulopathies (n = 33). There was no significant difference among the groups in terms of the urinary CD80 levels, and serum suPAR was not significantly higher in the FSGS group, as would have been expected. Urinary CD80 correlated positively with nephrotic syndrome, regardless of the type of glomerular disease. Neither biomarker correlated with proteinuria at six months after biopsy. Conclusion: In adults, urinary CD80 can serve as a marker of nephrotic syndrome but is not specific for MCD, whereas serum suPAR does not appear to be useful as a diagnostic or treatment response marker.<\/jats:p>","DOI":"10.3390\/diagnostics13020203","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T06:11:51Z","timestamp":1672899111000},"page":"203","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil"],"prefix":"10.3390","volume":"13","author":[{"given":"Renata de C\u00e1ssia","family":"Zen","sequence":"first","affiliation":[{"name":"Nephrology Department, Hospital das Cl\u00ednicas, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner Vasques","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Laboratory of Renal Pathophysiology, Hospital das Cl\u00ednicas, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivone","family":"Braga","sequence":"additional","affiliation":[{"name":"Laboratory of Renal Pathophysiology, Hospital das Cl\u00ednicas, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene Machado","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Laboratory of Renal Pathophysiology, Hospital das Cl\u00ednicas, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lect\u00edcia Barbosa","family":"Jorge","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital das Cl\u00ednicas, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-0063","authenticated-orcid":false,"given":"Luis","family":"Yu","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital das Cl\u00ednicas, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Woronik","sequence":"additional","affiliation":[{"name":"Laboratory of Renal Pathophysiology, Hospital das Cl\u00ednicas, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Bitencourt","family":"Dias","sequence":"additional","affiliation":[{"name":"Laboratory of Renal Pathophysiology, Hospital das Cl\u00ednicas, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0140-6736(74)91880-7","article-title":"Pathogenesis of lipoid nephrosis: A disorder of T-cell function","volume":"304","author":"Shalhoub","year":"1974","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1007\/s00467-016-3379-4","article-title":"Pathogenesis of proteinuria in idiopathic minimal change disease: Molecular mechanisms","volume":"31","author":"Clapp","year":"2016","journal-title":"Pediatr. 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