{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T13:16:58Z","timestamp":1786454218578,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Spinal cord injury (SCI) where the lower motor neuron is compromised leads to atrophy and degenerative changes in the respective muscle. This type of lesion becomes especially critical when the gluteal muscles and\/or the hamstrings are affected as they usually offer a cushioning effect to protect from skin injuries. Previous research conducted over the past 30 years has made advancements in the development of parameters for the optimal application of long pulse stimulation with the aim to restore muscle structure and trophic aspects in people with chronic SCI (&lt;20 years post-injury). This work provides an overview of previous achievements in the field through a narrative literature review before presenting preliminary results in the form of a case series from an ongoing study investigating the acute effects of six months of long pulse stimulation on the tissue composition of the gluteal muscles in five people with chronic SCI (&gt;20 years post-injury). Participants underwent a 33-min home-based long pulse stimulation program five times a week, and their muscle and adipose tissue thicknesses were assessed at baseline, after three and six months, respectively, using magnetic resonance imaging. The results show that the largest increase in muscle thickness occurred at the level of the height of the acetabulum (+44.37%; \u03c72(2) = 0.5; p = 0.779), whereas the most important decrease in adipose tissue occurred at the level of the sacroiliac joint (SIJ) reference (\u221211.43%; \u03c72(2) = 1.6; p = 0.449) within only six months of regular stimulation despite the preceding long denervation period. The underlying mechanism and physiology of muscular resuscitation from myofibrillar debris as presented in chronic denervation to functional contractile entities remain to be investigated further.<\/jats:p>","DOI":"10.3390\/diagnostics13020219","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T03:25:58Z","timestamp":1673234758000},"page":"219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Electrical Stimulation for Preventing Skin Injuries in Denervated Gluteal Muscles\u2014Promising Perspectives from a Case Series and Narrative Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Marie","family":"Alberty","sequence":"first","affiliation":[{"name":"International FES Centre<sup>\u00ae<\/sup>, Swiss Paraplegic Centre, Guido A. Z\u00e4ch Strasse 1, CH-6207 Nottwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9648-3649","authenticated-orcid":false,"given":"Winfried","family":"Mayr","sequence":"additional","affiliation":[{"name":"Medical University of Vienna, Center for Medical Physics and Biomedical Engineering, W\u00e4hringer G\u00fcrtel 18-20, AT-1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Bersch","sequence":"additional","affiliation":[{"name":"International FES Centre<sup>\u00ae<\/sup>, Swiss Paraplegic Centre, Guido A. Z\u00e4ch Strasse 1, CH-6207 Nottwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.4081\/bam.2014.1.5","article-title":"The Biology of Long-Term Denervated Skeletal Muscle","volume":"24","author":"Carlson","year":"2014","journal-title":"Eur. J. Transl. Myol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1525-1594.2005.29035.x","article-title":"Electrical Stimulation of Denervated Muscles: First Results of a Clinical Study","volume":"29","author":"Modlin","year":"2005","journal-title":"Artif. 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