{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:32:33Z","timestamp":1791286353205,"version":"4.1.0"},"reference-count":69,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Aortic aneurysms represent a very common pathology that can affect any segment of the aorta. These types of aneurysms can be localized on the thoracic segment or on the abdominal portion, with the latter being more frequent. Though there are similarities between thoracic and abdominal aortic aneurysms, these pathologies are distinct entities. In this article, we undertook a review regarding the different mechanisms that can lead to the development of aortic aneurysm, and we tried to identify the different manners of treatment. For a long time, aortic wall aneurysms may evolve in an asymptomatic manner, but this progressive dilatation of the aneurysm can lead to a potentially fatal complication consisting in aortic rupture. Because there are limited therapies that may delay or prevent the development of acute aortic syndromes, surgical management remains the most common manner of treatment. Even though, surgical management has improved much in the last years, thus becoming less invasive and sophisticated, the morbi-mortality linked to these therapies remains increased. The identification of the cellular and molecular networks triggering the formation of aneurysm would permit the discovery of modern therapeutic targets. Molecular and cellular mechanisms are gaining a bigger importance in the complex pathogenesis of aortic aneurysms. Future studies must be developed to compare the findings seen in human tissue and animal models of aortic aneurysm, so that clinically relevant conclusions about the aortic aneurysm formation and the pharmacological possibility of pathogenic pathways blockage can be drawn.<\/jats:p>","DOI":"10.3390\/diagnostics13020253","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T01:30:47Z","timestamp":1673314247000},"page":"253","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Molecular and Cellular Mechanisms Involved in Aortic Wall Aneurysm Development"],"prefix":"10.3390","volume":"13","author":[{"given":"Iris","family":"Bararu Bojan (Bararu)","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Morpho-Functional Sciences, Faculty of Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 16 Unirii Street, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-7761","authenticated-orcid":false,"given":"Carmen Elena","family":"Ple\u0219oianu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"Department of Clinical Cardiology, \u2018Prof. Dr. George I.M. Georgescu\u2019 Institute of Cardiovascular Diseases, 700503 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7050-8430","authenticated-orcid":false,"given":"Oana Viola","family":"Badulescu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Morpho-Functional Sciences, Faculty of Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 16 Unirii Street, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Vladeanu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Morpho-Functional Sciences, Faculty of Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 16 Unirii Street, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8942-1909","authenticated-orcid":false,"given":"Minerva Codruta","family":"Badescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Bojan","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Faculty of Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Ciocoiu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Morpho-Functional Sciences, Faculty of Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 16 Unirii Street, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/CIRCRESAHA.118.313187","article-title":"Cellular Mechanisms of Aortic Aneurysm Formation","volume":"124","author":"Quintana","year":"2019","journal-title":"Circ. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jvs.2010.05.090","article-title":"Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals","volume":"52","author":"Kent","year":"2010","journal-title":"J. Vasc. 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