{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:04:27Z","timestamp":1790996667336,"version":"4.1.0"},"reference-count":94,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Barrett\u2019s esophagus (BE) is a change in the distal esophageal mucosal lining, whereby metaplastic columnar epithelium replaces squamous epithelium of the esophagus. This change represents a pre-malignant mucosal transformation which has a known association with the development of esophageal adenocarcinoma. Gastroesophageal reflux disease is a risk factor for BE, other risk factors include patients who are Caucasian, age &gt; 50 years, central obesity, tobacco use, history of peptic stricture and erosive gastritis. Screening for BE remains selective based on risk factors, a screening program in the general population is not routinely recommended. Diagnosis of BE is established with a combination of endoscopic recognition, targeted biopsies, and histologic confirmation of columnar metaplasia. We aim to provide a comprehensive review of the epidemiology, pathogenesis, screening and advanced techniques of detecting and eradicating Barrett\u2019s esophagus.<\/jats:p>","DOI":"10.3390\/diagnostics13020321","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T03:40:34Z","timestamp":1673840434000},"page":"321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Barrett\u2019s Esophagus: An Updated Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Peter","family":"Stawinski","sequence":"first","affiliation":[{"name":"Long School of Medicine, Health Science Center, University of Texas at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Dziadkowiec","sequence":"additional","affiliation":[{"name":"Long School of Medicine, Health Science Center, University of Texas at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Kuo","sequence":"additional","affiliation":[{"name":"Long School of Medicine, Health Science Center, University of Texas at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Echavarria","sequence":"additional","affiliation":[{"name":"Long School of Medicine, Health Science Center, University of Texas at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreyas","family":"Saligram","sequence":"additional","affiliation":[{"name":"Long School of Medicine, Health Science Center, University of Texas at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"ref_1","unstructured":"Lowe, D., Kudaravalli, P., and Hsu, R. 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