{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:17:55Z","timestamp":1775164675648,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Odontogenic cysts (OCs) are etiologically diverse conditions with a shared origin in the jaws. Unfortunately, there is a scarcity of published data regarding OC frequency, treatment, and follow-up information in Saudi Arabia, especially from tertiary centers. Objectives: The study aims to assess the relative frequency, clinicopathological features, treatment, and follow-up of OCs in three tertiary medical centers. Methods and Material: OCs were identified from King Abdulaziz Medical City, King Fahad Medical City, and Prince Sultan Military Medical City from January 2010 to December 2021. Results: Three hundred and seventy-two cases of OCs were identified from the archive of three medical centers in Riyadh; one hundred and forty-nine (40%) cases were retrieved from Prince Sultan Military Medical City. The mean age of all OCs was 32 years (range 2\u201390), with 225 (60.4%) cases occurring in males. There was an almost equal distribution of OCs between the maxilla (47.0%) and the mandible (53.0%). The apical radicular cyst (ARC) accounted for half of the cases, followed by dentigerous cyst (DC) (29.3%) and odontogenic keratocyst (OKC) (14.2%). Enucleation was the most common treatment modality (52.8%), followed by excision (35.0%). Thirteen cases showed recurrence: one ARC, four DCs, and eight OKCs. Conclusion: This is the first large multicenter study of OCs in Riyadh, Saudi Arabia. All three centers showed that ARC was the most common, followed by DC and OKC.<\/jats:p>","DOI":"10.3390\/diagnostics13030355","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T03:45:16Z","timestamp":1674099916000},"page":"355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Frequency and Demographic Profile of Odontogenic Cysts in Riyadh, Saudi Arabia: Retrospective Multicenter Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1467-0913","authenticated-orcid":false,"given":"Asma","family":"Almazyad","sequence":"first","affiliation":[{"name":"College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, P.O. Box 3660, Riyadh 11481, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, P.O. Box 3660, Riyadh 11481, Saudi Arabia"},{"name":"Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affair, P.O. Box 22490, Riyadh 11426, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzouq","family":"Almutairi","sequence":"additional","affiliation":[{"name":"College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, P.O. Box 3660, Riyadh 11481, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8859-6712","authenticated-orcid":false,"given":"Nasser","family":"Almadan","sequence":"additional","affiliation":[{"name":"Prince Sultan Military Medical Center, P.O. Box 7897, Riyadh 12233, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9335-6828","authenticated-orcid":false,"given":"Mohammed","family":"Alamro","sequence":"additional","affiliation":[{"name":"College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, P.O. Box 3660, Riyadh 11481, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahad","family":"Maki","sequence":"additional","affiliation":[{"name":"College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, P.O. Box 3660, Riyadh 11481, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turki S.","family":"AlQuwayz","sequence":"additional","affiliation":[{"name":"Prince Sultan Military Medical Center, P.O. Box 7897, Riyadh 12233, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assem S.","family":"Alrumeh","sequence":"additional","affiliation":[{"name":"Prince Sultan Military Medical Center, P.O. Box 7897, Riyadh 12233, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/jicd.12044","article-title":"Frequency of odontogenic cysts and tumors: A systematic review","volume":"5","author":"Johnson","year":"2014","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_2","unstructured":"Bishop, J.A.C., John, K.C., Gale, N., Helliwell, T., Hyrcza, M.D., Lewis, J.S., Loney, E.L., Mehortra, R., Nete, O., and Muller, S. (2022). WHO Classification of Tumors of Head and Neck Tumours, Internatinal Agency for Research on Cancer. [5th ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s12105-011-0298-3","article-title":"Glandular odontogenic cyst: Analysis of 46 cases with special emphasis on microscopic criteria for diagnosis","volume":"5","author":"Fowler","year":"2011","journal-title":"Head Neck Pathol."},{"key":"ref_4","unstructured":"El-Naggar, A.K., Grandis, C.J., Takata, T., and Slootweg, P.J. (2017). WHO Classification of Head and Neck Tumours, IARC Publications. [4th ed.]."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/PAS.0000000000001407","article-title":"Biallelic PTCH1 Inactivation Is a Dominant Genomic Change in Sporadic Keratocystic Odontogenic Tumors","volume":"44","author":"Stojanov","year":"2020","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1600-0714.2006.00455.x","article-title":"Range and demographics of odontogenic cysts diagnosed in a UK population over a 30-year period","volume":"35","author":"Jones","year":"2006","journal-title":"J. Oral Pathol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s12105-019-01011-7","article-title":"Demographic and Clinical Characteristics of 5294 Jaw Cysts: A Retrospective Study of 38 Years","volume":"13","author":"Tamiolakis","year":"2019","journal-title":"Head Neck Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2334\/josnusd.53.361","article-title":"Odontogenic cysts: A retrospective study of 1227 cases in an Iranian population from 1987 to 2007","volume":"53","author":"Sharifian","year":"2011","journal-title":"J. Oral Sci."},{"key":"ref_9","first-page":"304","article-title":"Odontogenic cysts. A clinicopathological study","volume":"33","year":"2012","journal-title":"Saudi Med. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4103\/0975-8844.124251","article-title":"Prevalence of odontogenic cysts and tumors among UAE population","volume":"5","author":"Hariri","year":"2013","journal-title":"J. Orofac. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1159\/000330023","article-title":"Biopsied jaw lesions in Kuwait: A six-year retrospective analysis","volume":"20","author":"Ali","year":"2011","journal-title":"Med. Princ. Pract."},{"key":"ref_12","first-page":"E85","article-title":"Odontogenic cysts: Analysis of 2944 cases in Chile","volume":"12","author":"Ochsenius","year":"2007","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2334\/josnusd.51.581","article-title":"Odontogenic cysts: A clinicopathological study of 507 cases","volume":"51","author":"Avelar","year":"2009","journal-title":"J. Oral Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2334\/josnusd.48.59","article-title":"Odontogenic cysts: A clinical study of 695 cases","volume":"48","author":"Meningaud","year":"2006","journal-title":"J. Oral Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.4317\/medoral.17088","article-title":"Prevalence and distribution of odontogenic and nonodontogenic cysts in a Turkish population","volume":"17","author":"Acikgoz","year":"2012","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0030-4220(94)90299-2","article-title":"Relative incidence of odontogenic tumors and oral and jaw cysts in a Canadian population","volume":"77","author":"Daley","year":"1994","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2334\/josnusd.50.15","article-title":"Prevalence and distribution of odontogenic cysts in Sicily: 1986-2005","volume":"50","author":"Tortorici","year":"2008","journal-title":"J. Oral Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.joen.2009.02.012","article-title":"Nonsurgical root canal therapy of large cyst-like inflammatory periapical lesions and inflammatory apical cysts","volume":"35","author":"Lin","year":"2009","journal-title":"J. Endod."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0030-4220(87)90010-7","article-title":"The paradental cyst: A clinicopathologic study of 50 cases","volume":"64","author":"Ackermann","year":"1987","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-263X.2006.00683.x","article-title":"An analysis of oral and maxillofacial pathology found in children over a 30-year period","volume":"16","author":"Jones","year":"2006","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/jomfp.JOMFP_316_19","article-title":"Expression of stem cell marker cytokeratin 19 in reduced enamel epithelium, dentigerous cyst and unicystic ameloblastoma\u2014A comparative analysis","volume":"25","author":"Akhila","year":"2021","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0188-4409(00)00069-2","article-title":"Clinico-pathologic study of odontogenic cysts in a Mexican sample population","volume":"31","year":"2000","journal-title":"Arch. Med. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s12105-008-0060-7","article-title":"Odontogenic cysts: Analysis of 680 cases in Brazil","volume":"2","author":"Prockt","year":"2008","journal-title":"Head Neck Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bjoms.2020.08.011","article-title":"Non-neoplastic jaw cysts: A 30-year epidemiological study of 2150 cases in the Italian population","volume":"59","author":"Aquilanti","year":"2021","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_25","first-page":"102","article-title":"Eruption cysts: Retrospective clinical study of 36 cases","volume":"65","author":"Aguilo","year":"1998","journal-title":"ASDC J. Dent. Child"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/B978-0-444-62702-5.00008-1","article-title":"Basal cell nevus syndrome or Gorlin syndrome","volume":"132","author":"Thalakoti","year":"2015","journal-title":"Handb. Clin. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.ijom.2021.02.015","article-title":"Surgical management of the odontogenic keratocyst: A 20-year experience","volume":"50","author":"Mohanty","year":"2021","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.joms.2004.07.026","article-title":"A retrospective review of treatment of the odontogenic keratocyst","volume":"63","author":"Morgan","year":"2005","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_29","first-page":"CD008464","article-title":"Interventions for the treatment of keratocystic odontogenic tumours (KCOT, odontogenic keratocysts (OKC))","volume":"9","author":"Sharif","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1067\/moe.2001.113109","article-title":"Odontogenic keratocyst: Review of 256 cases for recurrence and clinicopathologic parameters","volume":"91","author":"Myoung","year":"2001","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/odi.12719","article-title":"Glandular odontogenic cyst: An updated analysis of 169 cases reported in the literature","volume":"24","author":"Chrcanovic","year":"2018","journal-title":"Oral Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s12663-012-0450-y","article-title":"Prevalence and distribution of odontogenic cyst in Indian population: A 10 year retrospective study","volume":"13","author":"Kambalimath","year":"2014","journal-title":"J. Maxillofac. Oral Surg."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/3\/355\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:09:25Z","timestamp":1760119765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/3\/355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,18]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["diagnostics13030355"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13030355","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,18]]}}}