{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:21:29Z","timestamp":1778181689730,"version":"3.51.4"},"reference-count":18,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Songjiang District tackling key science and technology research projects","award":["20sjkjgg32"],"award-info":[{"award-number":["20sjkjgg32"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Gastrointestinal stromal tumour (GIST) is a malignant tumour of the gastrointestinal lobe tissue, which mostly occurs in the gastrointestinal tract. Clinical manifestations can range from being benign to malignant. It mainly occurs in the gastric and small intestine. It may also develop in the colon, oesophagus, and bowel membranes, or outside the gastrointestinal tract and intestines. The pathological diagnosis of GIST depends on morphological measurements and immunohistochemistry. We report an interesting case in which the patient\u2019s gastroscopy indicated gastric malignant tumours, and the results of the contrast-enhanced computed tomography (CT) of the upper abdomen showed malignant stomach tumour accompanied by liver metastasis. After the patient knew about this diagnosis, she wanted to give up treatment. Finally, the gastric biopsy suggested positive CD34, CD117, DOG1, and Ki-67, which supported the diagnosis of GIST. We hope that, through this case, we could improve clinicians\u2019 understanding of GIST and improve its diagnosis and treatment.<\/jats:p>","DOI":"10.3390\/diagnostics13030376","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T05:50:20Z","timestamp":1674107420000},"page":"376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gastrointestinal Stromal Tumour with Liver Metastasis Presenting as Gastric Cancer"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7416-4281","authenticated-orcid":false,"given":"Yongwei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Songjiang Hospital, School of Medicine, Shanghai Jiaotong University, No. 746, Zhongsanzhong Road, Songjiang District, Shanghai 201600, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bacui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Songjiang Hospital, School of Medicine, Shanghai Jiaotong University, No. 746, Zhongsanzhong Road, Songjiang District, Shanghai 201600, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Songjiang Hospital, School of Medicine, Shanghai Jiaotong University, No. 746, Zhongsanzhong Road, Songjiang District, Shanghai 201600, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41572-021-00254-5","article-title":"Gastrointestinal stromal tumours","volume":"7","author":"Blay","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"iv267","DOI":"10.1093\/annonc\/mdy320","article-title":"ESMO Guidelines Committee and EURACAN. Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"29","author":"Casali","year":"2018","journal-title":"Ann. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"853","DOI":"10.6004\/jnccn.2014.0080","article-title":"Gastrointestinal stromal tumors, version 2.2014","volume":"12","author":"Mehren","year":"2014","journal-title":"J. Natl. Compr. Canc Netw."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Pinieux, G., Karanian, M., Le Loarer, F., Le Guellec, S., Chabaud, S., Terrier, P., Bouvier, C., Batistella, M., Neuville, A., and Robin, Y.-M. (2021). Nationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0246958"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.canep.2015.10.031","article-title":"Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies","volume":"40","author":"Sandvik","year":"2016","journal-title":"Cancer Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6195","DOI":"10.3748\/wjg.v26.i40.6195","article-title":"Prevalence, diagnosis, and treatment of primary hepatic gastrointestinal stromal tumors","volume":"26","author":"Qian","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_7","first-page":"889","article-title":"Diagnosis and management of gastrointestinal stromal tumours: An up-to-date literature review","volume":"13","author":"Mekkodathil","year":"2017","journal-title":"J. Cancer Res. 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Care Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1586\/14737140.2014.952284","article-title":"Managing GIST in the imatinib era: Optimization of adjuvant therapy","volume":"14","author":"Trent","year":"2014","journal-title":"Expert Rev Anticancer Ther."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/3\/376\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:10:30Z","timestamp":1760119830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/3\/376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,19]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["diagnostics13030376"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13030376","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,19]]}}}