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Science Foundation of Shandong Province","award":["8210041176"],"award-info":[{"award-number":["8210041176"]}]},{"name":"Natural Science Foundation of Shandong Province","award":["22S31903000"],"award-info":[{"award-number":["22S31903000"]}]},{"name":"Natural Science Foundation of Shandong Province","award":["19441905800"],"award-info":[{"award-number":["19441905800"]}]},{"name":"Natural Science Foundation of Shandong Province","award":["2019C03045"],"award-info":[{"award-number":["2019C03045"]}]},{"name":"Natural Science Foundation of Shandong Province","award":["ZR2020MF105"],"award-info":[{"award-number":["ZR2020MF105"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Myopia is a significant cause of visual impairment which may lead to many complications. However, the understanding of the mechanisms of myopia is still limited. In this paper, in order to investigate the development and the treatment of myopia, we analyzed the biological structure parameters of mice eyes, obtained from optical coherence tomography (OCT), and the optical performance of mice eyes calculated using ZEMAX software (ZEMAX Development Corporation, Kirkland, WA, USA) in which the optical model was built on the segment-by-segment optically corrected OCT 3D-images. Time-serial evaluation of three groups of mice eyes (form-deprivation myopia mice eyes, normal mice eyes, and atropine-treated myopia mice eyes) was performed. In addition to the biological structure parameters, imaging performance with the development of root-mean-square wavefront aberration at six filed angles was compared and analyzed. Results show that the biological structure parameters of the eye are closely related to the development of myopia. The peripheral defocus of the retina has a significant impact on inducing myopia, which verifies the new theory of myopia development. The delaying effect of atropine solution on myopia development is shown to verify the therapeutic effect of the medicine. This study provides technical support for the investigation of the myopia mechanism.<\/jats:p>","DOI":"10.3390\/diagnostics13030379","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T06:22:10Z","timestamp":1674109330000},"page":"379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Time-Serial Evaluation of the Development and Treatment of Myopia in Mice Eyes Using OCT and ZEMAX"],"prefix":"10.3390","volume":"13","author":[{"given":"Xueqing","family":"Ding","sequence":"first","affiliation":[{"name":"College of Science, Shanghai Institute of Technology, Shanghai 201418, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhen","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Computer Science, Qufu Normal University, Qufu 276825, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Computer Science, Qufu Normal University, Qufu 276825, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilei","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiao","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixia","family":"Dai","sequence":"additional","affiliation":[{"name":"College of Science, Shanghai Institute of Technology, Shanghai 201418, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/519276a","article-title":"The myopia boom","volume":"519","author":"Dolgin","year":"2015","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1475-1313.2005.00298.x","article-title":"Myopia and associated pathological complications","volume":"25","author":"Saw","year":"2005","journal-title":"Ophthalmic Physiol. Opt. J. Br. Coll. Ophthalmic Opt. (Optom.)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ajo.2016.03.019","article-title":"Macular Bruch Membrane Holes in Highly Myopic Patchy Chorioretinal Atrophy","volume":"166","author":"Jonas","year":"2016","journal-title":"Am. J. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1038\/s41598-018-20272-w","article-title":"A highly efficient murine model of experimental myopia","volume":"8","author":"Jiang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1364\/BOE.8.002386","article-title":"Three-dimensional MRI study of the relationship between eye dimensions, retinal shape and myopia","volume":"8","author":"Pope","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"ref_7","first-page":"58","article-title":"Comparison of anterior section parameters using anterior segment optical coherence tomography and ultrasound biomicroscopy in myopic patients after ICL implantation","volume":"9","author":"Zhang","year":"2016","journal-title":"Int. J. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1167\/iovs.13-12630","article-title":"The ability of macular parameters and circumpapillary retinal nerve fiber layer by three SD-OCT instruments to diagnose highly myopic glaucoma","volume":"54","author":"Akashi","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"116008","DOI":"10.1117\/1.JBO.17.11.116008","article-title":"Comparison of Schlemm\u2019s canal\u2019s biological parameters in primary open-angle glaucoma and normal human eyes with swept source optical","volume":"17","author":"Wang","year":"2012","journal-title":"J. Biomed. Opt."},{"key":"ref_10","first-page":"629","article-title":"Advances of application with intraoperative coherence optical tomography in ophthalmic surgery","volume":"51","author":"Zhang","year":"2015","journal-title":"Chin. J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1364\/OE.10.000397","article-title":"Correction of geometric and refractive image distortions in optical coherence tomography applying Fermat\u2019s principle","volume":"10","author":"Westphal","year":"2002","journal-title":"Opt. Express"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/OPX.0000000000000725","article-title":"Distortion Correction of Visante Optical Coherence Tomography Cornea Images","volume":"92","author":"Ramasubramanian","year":"2015","journal-title":"Optom. Vis. Sci. Off. Publ. Am. Acad. Optom."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"615","DOI":"10.14232\/actacyb.23.2.2017.11","article-title":"An approach to the quantitative assessment of retinal layer distortions and subretinal fluid in SD-OCT images","volume":"23","author":"Katona","year":"2017","journal-title":"Acta Cybern."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1364\/BOE.10.004815","article-title":"Direct modeling of foveal pit morphology from distortion-corrected OCT images","volume":"10","author":"Breher","year":"2019","journal-title":"Biomedical optics express"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e202200146","DOI":"10.1002\/jbio.202200146","article-title":"Correction of refractive distortion in whole-eye optical coherence tomography imaging of the mouse eye","volume":"15","author":"Tan","year":"2022","journal-title":"J. Biophotonics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1475-1313.2005.00297.x","article-title":"Aberrations and myopia","volume":"25","author":"Charman","year":"2005","journal-title":"Ophthalmic Physiol. Opt. J. Br. Coll. Ophthalmic Opt."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuron.2004.08.008","article-title":"Homeostasis of eye growth and the question of myopia","volume":"43","author":"Wallman","year":"2004","journal-title":"Neuron"},{"key":"ref_18","first-page":"1810","article-title":"Distortion-corrected retinal curvature using a Fourier domain mode locking (FDML) laser ultrawide-field optical coherence tomography (OCT)","volume":"62","author":"Tan","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_19","first-page":"2687","article-title":"Retinal and foveal shape integrity is preserved in myopia","volume":"61","author":"Ohlendorf","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3928\/1081-597X-19950701-08","article-title":"Model for deriving the optical performance of the myopic eye corrected with an intracorneal ring","volume":"11","author":"Patel","year":"1995","journal-title":"J. Refract. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2147\/OPTO.S167297","article-title":"Visual performance of myopia control soft contact lenses in non-presbyopic myopes","volume":"10","author":"Sha","year":"2018","journal-title":"Clin. Optom."},{"key":"ref_22","first-page":"203","article-title":"Average optical performance of the human eye as a function of age in a normal population","volume":"40","author":"Guirao","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0042-6989(99)00156-X","article-title":"Monochromatic aberrations in the accommodated human eye","volume":"40","author":"He","year":"2000","journal-title":"Vis. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/OPX.0000000000001513","article-title":"Longitudinal Changes in Optical Quality, Spatial Vision, and Depth Vision after Laser Refractive Surgery for Myopia","volume":"97","author":"Sarkar","year":"2020","journal-title":"Optom. Vis. Sci. Off. Publ. Am. Acad. Optom."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3109\/02713683.2014.903498","article-title":"The effect of fractal contact lenses on peripheral refraction in myopic model eyes","volume":"39","author":"Benlloch","year":"2014","journal-title":"Curr. Eye Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Shaker, L.M., Al-Amiery, A.A., Kadhum AA, H., and Takriff, M.S. (2020). Manufacture of Contact Lens of Nanoparticle-Doped Polymer Complemented with ZEMAX. Nanomaterials, 10.","DOI":"10.3390\/nano10102028"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1016\/j.visres.2006.01.011","article-title":"Optical aberrations in the mouse eye","volume":"46","author":"Llorente","year":"2006","journal-title":"Vis. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1167\/iovs.09-4153","article-title":"Mouse experimental myopia has features of primate myopia","volume":"51","author":"Tkatchenko","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jneumeth.2006.10.011","article-title":"Head-mounted goggles for murine form deprivation myopia","volume":"161","author":"Faulkner","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"R207","DOI":"10.1088\/0022-3727\/36\/14\/201","article-title":"Techniques for depth-resolved imaging through turbid media including coherence-gated imaging","volume":"36","author":"Dunsby","year":"2003","journal-title":"J. Phys. D Appl. Phys."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1088\/0031-9155\/49\/7\/015","article-title":"Correction of distortions in optical coherence tomography imaging of the eye","volume":"49","author":"Podoleanu","year":"2004","journal-title":"Phys. Med. Biol."},{"key":"ref_32","first-page":"851","article-title":"Neurofibromatosis: An update of ophthalmic characteristics and applications of optical coherence tomography","volume":"10","author":"Abdolrahimzadeh","year":"2016","journal-title":"Clin. Ophthalmol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1167\/iovs.10-6340","article-title":"Postnatal elongation of eye size in DBA\/2J mice compared with C57BL\/6J mice: In vivo analysis with whole-eye OCT","volume":"52","author":"Chou","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1167\/iovs.13-13362","article-title":"Unaltered retinal dopamine levels in a C57BL\/6 mouse model of form-deprivation myopia","volume":"56","author":"Wu","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.exer.2018.03.027","article-title":"Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations","volume":"172","author":"Zhang","year":"2018","journal-title":"Exp. Eye Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.visres.2004.03.011","article-title":"A paraxial schematic eye model for the growing C57BL\/6 mouse","volume":"44","author":"Schmucker","year":"2004","journal-title":"Vis. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/00006324-199211000-00005","article-title":"Crystalline lens power in myopia","volume":"69","author":"Garner","year":"1992","journal-title":"Optom. Vis. Sci. Off. Publ. Am. Acad. Optom."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/OPX.0000000000000978","article-title":"Animal Studies and the Mechanism of Myopia-Protection by Light?","volume":"93","author":"Ashby","year":"2016","journal-title":"Optom. Vis. Sci. Off. Publ. Am. Acad. Optom."},{"key":"ref_39","first-page":"670","article-title":"Retinoic acid metabolic change in retina and choroid of the guinea pig with lens-induced myopia","volume":"5","author":"Mao","year":"2012","journal-title":"Int. J. Ophthalmol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00006324-199707000-00015","article-title":"Ocular components measured by keratometry, phakometry, and ultrasonography in emmetropic and myopic optometry students","volume":"74","author":"Goss","year":"1997","journal-title":"Optom. Vis. Sci. Off. Publ. Am. Acad. Optom."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1364\/BOE.10.006084","article-title":"Morphological changes of human crystalline lens in myopia","volume":"10","author":"Muralidharan","year":"2019","journal-title":"Biomed. Opt. Express"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exer.2014.05.015","article-title":"Refractive index measurement of the mouse crystalline lens using optical coherence tomography","volume":"125","author":"Chakraborty","year":"2014","journal-title":"Exp. Eye Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1364\/JOSAA.20.001841","article-title":"Optical aberrations of intraocular lenses measured in vivo and in vitro","volume":"20","author":"Barbero","year":"2003","journal-title":"J. Opt. Soc. America. A Opt. Image Sci. Vis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1097\/OPX.0000000000000905","article-title":"Peripheral Refraction, Peripheral Eye Length, and Retinal Shape in Myopia","volume":"93","author":"Verkicharla","year":"2016","journal-title":"Optom. Vis. Sci. Off. Publ. Am. Acad. Optom."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Li, W., Nan, X., and Mo, Z. (2010, January 24\u201326). Effects of budgetary goal characteristics on managerial attitudes and performance. Proceedings of the 2010 International Conference on Management and Service Science, Wuhan, China.","DOI":"10.1109\/ICMSS.2010.5578521"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/3\/379\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:10:39Z","timestamp":1760119839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/3\/379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,19]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["diagnostics13030379"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13030379","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,19]]}}}