{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:26:35Z","timestamp":1792095995360,"version":"4.4.0"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Purpose: After endovascular aneurysm repair (EVAR), an increased [18F]FDG uptake may be observed at PET\/CT, being common to both vascular graft\/endograft infection (VGEI) and sterile post-surgical inflammation. Increased non-specific metabolic activity, due to foreign body reaction, can persist for several years after surgery, thus complicating the interpretation of PET\/CT studies. In this paper, we aimed to assess [18F]FDG distribution at different time-points after the implant of abdominal Endurant\u00ae endografts in patients without suspicion of infection. Methods: We retrospectively evaluated [18F]FDG\/CT in 16 oncological patients who underwent abdominal aortic aneurysm exclusion with Endurant\u00ae grafts. Patients had no clinical suspicion of infection and were followed up for at least 24 months after scan. [18F]FDG PET\/CT scans were interpreted using both visual and semi-quantitative analyses. Results: The time between the EVAR procedure and [18F]FDG PET\/CT ranged between 1 and 36 months. All grafts showed mild and diffuse [18F]FDG uptake without a focal pattern. Mean values of SUVmax were 2.63 \u00b1 0.48 (95% CI 2.38\u20132.88); for SUVmean 1.90 \u00b1 0.33 (95% CI 1.72\u20132.08); for T\/B ratios 1.43 \u00b1 0.41 (95% CI 1.21\u20131.65). SUVmax and SUVmean were not correlated to the time elapsed from the procedure, but we observed a declining trend in T\/B ratio over time. Conclusions: Endovascular implant of Endurant\u00ae grafts does not cause a significant inflammatory reaction. The evidence of faint and diffuse [18F]FDG uptake along the graft can reliably exclude an infection, even in early post-procedural phases. Therefore, in patients with a low probability of VGEI, [18F]FDG PET\/CT can also be performed immediately after EVAR.<\/jats:p>","DOI":"10.3390\/diagnostics13030409","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T03:48:08Z","timestamp":1674445688000},"page":"409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["[18F]FDG Uptake in Non-Infected Endovascular Grafts: A Retrospective Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-5059","authenticated-orcid":false,"given":"Chiara","family":"Lauri","sequence":"first","affiliation":[{"name":"Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Sant\u2019Andrea Hospital, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8923-648X","authenticated-orcid":false,"given":"Alberto","family":"Signore","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Sant\u2019Andrea Hospital, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Campagna","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Sant\u2019Andrea Hospital, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-9199","authenticated-orcid":false,"given":"Francesco","family":"Aloisi","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of Clinical and Molecular Medicine, Sant\u2019Andrea Hospital, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5853-9410","authenticated-orcid":false,"given":"Maurizio","family":"Taurino","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of Clinical and Molecular Medicine, Sant\u2019Andrea Hospital, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1312-1915","authenticated-orcid":false,"given":"Pasqualino","family":"Sirignano","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Sant\u2019Andrea Hospital, Department of General and Specialistic Surgery, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.23736\/S0021-9509.22.12330-X","article-title":"Italian Guidelines for Vascular Surgery Collaborators\u2014AAA Group. 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