{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:18:07Z","timestamp":1764260287326,"version":"build-2065373602"},"reference-count":13,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Young Scientists","doi-asserted-by":"publisher","award":["20K16905"],"award-info":[{"award-number":["20K16905"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Juvenile polyps, typically localized in the rectum and sigmoid colon, are a common cause of pediatric bloody stool. An isolated small intestinal juvenile polyp is uncommon and generally difficult to diagnose. The first case of an isolated juvenile polyp diagnosed by abdominal ultrasonography before acute abdomen had developed and resected by double-balloon endoscopy is presented along with a review of previous reports including this case. A two-year-old Japanese boy was referred to our institute for further evaluation of anemia persisting from one year of age. Laboratory findings showed mild iron deficiency anemia and elevated fecal human hemoglobin (Hb) and fecal calprotectin values. Upper and lower endoscopic findings showed no abnormalities. Because the abdominal ultrasonography performed one year later demonstrated a 15 mm jejunal polyp, combined with a similar finding on small intestinal capsule endoscopy, this was diagnosed as an isolated lesion. The lesion was resected by cautery with double-balloon endoscopy and diagnosed as a juvenile polyp pathologically. All clinical symptoms disappeared, and all laboratory data improved after treatment, without recurrence for more than one year after the procedure. Abdominal ultrasonographic screening and the fecal calprotectin value led to the diagnosis and non-surgical invasive treatment of an isolated small intestinal juvenile polyp.<\/jats:p>","DOI":"10.3390\/diagnostics13030494","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T08:28:23Z","timestamp":1675067303000},"page":"494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Isolated Intestinal Juvenile Polyp Diagnosed by Abdominal Ultrasonography and Resected by Double-Balloon Endoscopy: A Case Report and Literature Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6561-2855","authenticated-orcid":false,"given":"Masumi","family":"Nagata","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6317-4305","authenticated-orcid":false,"given":"Keisuke","family":"Jimbo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyasu","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3749-7789","authenticated-orcid":false,"given":"Kosuke","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Tokushima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9969-3454","authenticated-orcid":false,"given":"Mitsuyoshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4708-8049","authenticated-orcid":false,"given":"Takahiro","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00383-004-1194-7","article-title":"Juvenile colorectal polyps in children: Experience in Pakistan","volume":"20","author":"Mandhan","year":"2004","journal-title":"Pediatr. Surg. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"873624","DOI":"10.3389\/fsurg.2022.873624","article-title":"Colocolic intussusception in children: A case series and review of the literature","volume":"9","author":"Yan","year":"2022","journal-title":"Front. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/ajg.2010.473","article-title":"High cumulative risk of intussusception in patients with Peutz\u2013Jeghers Syndrome: Time to update surveillance guidelines?","volume":"106","author":"Wagner","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.gie.2012.04.443","article-title":"Enteroscopic and radiologic diagnoses, treatment, and prognoses of small-bowel tumors","volume":"76","author":"Honda","year":"2012","journal-title":"Gastrointest. Endosc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/MPG.0000000000002813","article-title":"Endoscopic removal of a single, painless, juvenile polyp in the small intestine causing anemia","volume":"71","author":"Krasaelap","year":"2020","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_6","first-page":"856765","article-title":"Laparoscopic-assisted resection of jejunojejunal intussusception caused by a juvenile polyp in an adult","volume":"2014","author":"Kang","year":"2014","journal-title":"Case Rep. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jpedsurg.2011.10.063","article-title":"Laparoscopic-assisted resection of juvenile polyp of the jejunum in a 3-year-old girl","volume":"47","author":"Ceccanti","year":"2012","journal-title":"J. Pediatr. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/s005950200160","article-title":"Juvenile polyps in the small intestine presenting as jejunojejunal intussusception in a 10-year-old child: Report of a case","volume":"32","author":"Sah","year":"2002","journal-title":"Surg. Today"},{"key":"ref_9","first-page":"855","article-title":"Intestinal polyp of infrequent localization: Presentation of 2 cases","volume":"21","year":"1984","journal-title":"An. Esp. Pediatr."},{"key":"ref_10","first-page":"89","article-title":"Juvenile polyp in the small bowel (author\u2019s transl)","volume":"33","author":"Zimmermann","year":"1981","journal-title":"Z. Kinderchir."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5223\/pghn.2022.25.1.52","article-title":"Juvenile polyps in Bangladeshi children and their association with fecal calprotectin as a biomarker","volume":"25","author":"Das","year":"2022","journal-title":"Pediatr. Gastroenterol. Hepatol. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Hestvik, E., Tumwine, J.K., Tylleskar, T., Grahnquist, L., Ndeezi, G., Kaddu-Mulindwa, D.H., Aksnes, L., and Olafsdottir, E. (2011). Faecal calprotectin concentrations in apparently healthy children aged 0-12 years in urban Kampala, Uganda: A community-based survey. BMC. Pediatr., 11.","DOI":"10.1186\/1471-2431-11-9"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/MPG.0000000000001542","article-title":"Fecal calprotectin and eosinophil-derived neurotoxin in healthy children between 0 and 12 years","volume":"65","author":"Roca","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/3\/494\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:19:09Z","timestamp":1760120349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/3\/494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,29]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["diagnostics13030494"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13030494","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2023,1,29]]}}}