{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:11:52Z","timestamp":1770833512371,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institut M\u00e9rieux at Lyon France","award":["G74882-2017"],"award-info":[{"award-number":["G74882-2017"]}]},{"name":"Institut de Recherche pour le D\u00e9veloppement (IRD)","award":["G74882-2017"],"award-info":[{"award-number":["G74882-2017"]}]},{"name":"SCAC\u2014Cultural and Cooperation Department\u2014French Embassy","award":["G74882-2017"],"award-info":[{"award-number":["G74882-2017"]}]},{"name":"Scholarship Secretariat Ghana","award":["G74882-2017"],"award-info":[{"award-number":["G74882-2017"]}]},{"name":"The Danish International Development Agency (DANIDA)","award":["G74882-2017"],"award-info":[{"award-number":["G74882-2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Among the barriers to accessing adequate treatment and high-level monitoring for malaria febrile patients is the lack of effective prognostic markers. Neopterin, which is a marker of monocyte\/macrophage activation, was found have increased during severe malaria. In this study, we used quantitative ELISA in order to assess the levels of plasma soluble neopterin in 151 patients from a cohort of Beninese children with severe malaria. We evaluated the prognostic accuracy of this molecule in order to predict the outcome of the disease. Our results show that neopterin levels were not significantly different between patients with different forms of severe malaria, including severe non-cerebral malaria (SNCM) and cerebral malaria (CM). However, the levels of this molecule were found to be higher in patients with severe malarial anemia (SMA) among both CM and SNCM cases (p-value = 0.02). Additionally, the levels of this molecule were found to be higher in patients who died from these pathologies compared to those who survived among the two clinical groups (p-value &lt; 0.0001) and within the same group (p-value &lt; 0.0001 for the CM group, p-value = 0.0046 for the SNCM group). The AUC-ROC for fatality among all the severe cases was 0.77 with a 95%CI of (0.69\u20130.85). These results suggest that plasma neopterin levels constitute a potential biomarker for predicting fatality among severe falciparum malaria patients.<\/jats:p>","DOI":"10.3390\/diagnostics13030528","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T04:27:02Z","timestamp":1675225622000},"page":"528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High Plasma Levels of Neopterin Are Associated with Increased Mortality among Children with Severe Malaria in Benin"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8963-6595","authenticated-orcid":false,"given":"Samuel Odarkwei","family":"Blankson","sequence":"first","affiliation":[{"name":"MERIT, IRD, Universit\u00e9 de Paris Cit\u00e9, 75006 Paris, France"},{"name":"West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra LG 54, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-651X","authenticated-orcid":false,"given":"Lauriane","family":"Rietmeyer","sequence":"additional","affiliation":[{"name":"MERIT, IRD, Universit\u00e9 de Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6060-9497","authenticated-orcid":false,"given":"Patrick","family":"Tettey","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra LG 54, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4201-2133","authenticated-orcid":false,"given":"Liliane","family":"Dikroh","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra LG 54, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Tornyigah","sequence":"additional","affiliation":[{"name":"MERIT, IRD, Universit\u00e9 de Paris Cit\u00e9, 75006 Paris, France"},{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra LG 54, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5506-1095","authenticated-orcid":false,"given":"Rafiou","family":"Adamou","sequence":"additional","affiliation":[{"name":"Institut de Recherche Clinique du Benin (IRCB), Calavi, Benin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6736-9476","authenticated-orcid":false,"given":"Azizath","family":"Moussiliou","sequence":"additional","affiliation":[{"name":"Institut de Recherche Clinique du Benin (IRCB), Calavi, Benin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Padounou","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de l\u2019Oueme, Porto-Novo, Benin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annick","family":"Amoussou","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, Centre Hospitalo-Universitaire, Surul\u00e9r\u00e9 (CHU-Surul\u00e9r\u00e9), Cotonou, Benin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedicta Ayiedu","family":"Mensah","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra LG 54, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maroufou J.","family":"Alao","sequence":"additional","affiliation":[{"name":"D\u00e9partement de P\u00e9diatrie, H\u00f4pital M\u00e8re-Enfant la Lagune (CHUMEL), Cotonou, Benin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Awandare","sequence":"additional","affiliation":[{"name":"West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra LG 54, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicaise Tuikue","family":"Ndam","sequence":"additional","affiliation":[{"name":"MERIT, IRD, Universit\u00e9 de Paris Cit\u00e9, 75006 Paris, France"},{"name":"Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra LG 54, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Roussilhon","sequence":"additional","affiliation":[{"name":"Institut Pasteur, 28 Rue du Docteur Roux, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachida","family":"Tahar","sequence":"additional","affiliation":[{"name":"MERIT, IRD, Universit\u00e9 de Paris Cit\u00e9, 75006 Paris, France"},{"name":"Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra LG 54, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"196432","DOI":"10.1155\/2013\/196432","article-title":"Neopterin in Diagnosis and Monitoring of Infectious Diseases","volume":"2013","author":"Eisenhut","year":"2013","journal-title":"J. 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