{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:15:47Z","timestamp":1784099747378,"version":"3.55.0"},"reference-count":16,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kyungpook National University Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>In patients with thyroid nodules, if the cervical lymph nodes gradually enlarge, a histological confirmation is required to rule out malignancy. Here is a case of benign intranodal thyroid tissue with cystic changes resembling lymph node metastasis of a papillary thyroid carcinoma. A 47-year-old man received ethanol sclerotherapy because of repeated enlargement of the thyroid gland 2 years prior to presentation. Subsequently, the patient underwent abscess removal from the deep neck and partial lobectomy of the attached left thyroid gland. Two months before the visit, extensive cervical lymphadenopathy was detected on ultrasonography (US) and computed tomography (CT). Total thyroidectomy and cervical lymph node dissection were performed to differentiate between metastatic papillary carcinoma of the thyroid gland and benign thyroid inclusions. Microscopic examination revealed multiple variable-sized nodules of benign thyroid follicles with cystic changes in both thyroid glands and bilateral cervical lymph nodes. An occult papillary microcarcinoma strongly positive for HBME-1 was also observed in the left thyroid lobe. However, the benign intranodal thyroid tissue was negative in both the real-time PCR-based BRAF V600E mutation test and HBME-1 immunohistochemical stain. Similarly, benign intranodal thyroid tissue can be enlarged by multiple cystic changes in a large number of lymph nodes along the neck node chain. For the differentiation of metastatic thyroid papillary carcinoma, real-time PCR-based BRAF V600E mutation test and HBME-1 immunohistochemical staining in addition to histological examination are helpful.<\/jats:p>","DOI":"10.3390\/diagnostics13030577","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T04:25:28Z","timestamp":1675657528000},"page":"577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Benign Intranodal Thyroid Tissue Similar to Nodal Metastasis of Thyroid Papillary Carcinoma: A Rare Case Report"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3634-9127","authenticated-orcid":false,"given":"Yoo-Na","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine, School of Medicine, Kyungpook National University, 680 Guk-chaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Guen","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1177\/1066896910382544","article-title":"Benign salivary gland tissue inclusion in a pulmonary hilar lymph node from a patient with invasive well-differentiated adenocarcinoma of the lung: A potential misinterpretation for the staging of carcinoma","volume":"19","author":"Lewis","year":"2011","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/1097-0142(196903)23:3<747::AID-CNCR2820230331>3.0.CO;2-9","article-title":"Benign nevus cells in the capsule of lymph nodes","volume":"23","author":"Johnson","year":"1969","journal-title":"Cancer"},{"key":"ref_3","first-page":"384","article-title":"Benign epithelial inclusion cyst in an axillary lymph node","volume":"88","author":"Hong","year":"1988","journal-title":"N. Y. State J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1006\/gyno.2000.5867","article-title":"Benign mullerian inclusions in pelvic and paraaortic lymph nodes","volume":"78","author":"Reich","year":"2000","journal-title":"Gynecol. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/jcp.47.3.245","article-title":"Benign lymph node inclusions mimicking metastatic carcinoma","volume":"47","author":"Fisher","year":"1994","journal-title":"J. Clin. Pathol."},{"key":"ref_6","first-page":"e7172","article-title":"Benign Ectopic Thyroid Tissue in the Neck: A Case Report of a Rare Finding","volume":"12","author":"Otondi","year":"2020","journal-title":"Cureus"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/1097-0142(197607)38:1<361::AID-CNCR2820380152>3.0.CO;2-8","article-title":"Ectopic thyroid tissue in the neck. Benign or malignant?","volume":"38","author":"Moses","year":"1976","journal-title":"Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/1097-0142(196908)24:2<302::AID-CNCR2820240213>3.0.CO;2-V","article-title":"Microscopically benign thyroid follicles in cervical lymph nodes. 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Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3348\/kjr.2018.0696","article-title":"Ethanol Ablation of the Thyroid Nodules: 2018 Consensus Statement by the Korean Society of Thyroid Radiology","volume":"20","author":"Hahn","year":"2019","journal-title":"Korean J. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/1097-0142(19860801)58:3<715::AID-CNCR2820580319>3.0.CO;2-P","article-title":"Occult papillary carcinoma of the thyroid in children and young adults. A systemic autopsy study in Finland","volume":"58","author":"Franssila","year":"1986","journal-title":"Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/hed.10304","article-title":"The prevalence and significance of clinically unsuspected neoplasms in cervical lymph nodes","volume":"25","author":"Westra","year":"2003","journal-title":"Head Neck"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"E106","DOI":"10.1002\/hed.23886","article-title":"Benign intranodal thyroid tissue mimicking nodal metastasis in a patient with papillary thyroid carcinoma: A case report","volume":"37","author":"Lee","year":"2015","journal-title":"Head Neck"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.7863\/ultra.32.7.1173","article-title":"Sonographic features of cervical lymph nodes after thyroidectomy for papillary thyroid carcinoma","volume":"32","author":"Kim","year":"2013","journal-title":"J. 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