{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:50:57Z","timestamp":1788306657463,"version":"build-2803163510"},"reference-count":54,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CMKP","award":["501-1-020-19-22"],"award-info":[{"award-number":["501-1-020-19-22"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: The role of platelets in the immune response against influenza has been raised, and a diagnostic or prognostic value of platelet parameter abnormalities, including platelet count (PLT), or mean platelet volume (MPV), has been suggested. The study aimed to analyze the prognostic value of platelet parameters in children hospitalized due to laboratory-confirmed influenza. Methods: We retrospectively verified the platelet parameters (PLT, MPV, MPV\/PLT, and PLT\/lymphocyte ratio regarding the influenza complications (acute otitis media, pneumonia, and lower respiratory tract infection\u2014LRTI), and the clinical course (antibiotic treatment, tertiary care transfer, and death). Results: An abnormal PLT was observed in 84 out of 489 laboratory-confirmed cases (17.2%, 44 thrombocytopaenia cases, and 40 thrombocytoses). Patients\u2019 age correlated negatively with PLT (rho = \u22120.46) and positively with MPV\/PLT (rho = 0.44), while MPV was not age-dependent. The abnormal PLT correlated with increased odds of complications (OR = 1.67), including LRTI (OR = 1.89). Thrombocytosis was related to increased odds of LRTI (OR = 3.64), and radiologically\/ultrasound-confirmed pneumonia (OR = 2.15), mostly in children aged under 1 year (OR = 4.22 and OR = 3.79, respectively). Thrombocytopaenia was related to antibiotic use (OR = 2.41) and longer hospital stays (OR = 3.03). A lowered MPV predicted a tertiary care transfer (AUC = 0.77), while MPV\/PLT was the most versatile parameter in predicting LRTI (AUC = 0.7 in &lt;1 yo), pneumonia (AUC = 0.68 in &lt;1 yo), and antibiotic treatment (AUC = 0.66 in 1\u20132 yo and AUC = 0.6 in 2\u20135 yo). Conclusions: Platelet parameters, including PLT count abnormalities and MPV\/PLT ratio, are related to the increased odds of complications and a more severe disease course, and may add important data in assessing pediatric influenza patients, but should be interpreted cautiously due to age-related specificities.<\/jats:p>","DOI":"10.3390\/diagnostics13040634","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T02:32:07Z","timestamp":1675909927000},"page":"634","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Platelet Abnormalities in Children with Laboratory-Confirmed Influenza"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3167-3975","authenticated-orcid":false,"given":"August","family":"Wrotek","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Centre of Postgraduate Medical Education, Marymoncka 99\/103, 01-813 Warsaw, Poland"},{"name":"Department of Pediatrics, Bielanski Hospital, Ceg\u0142owska 80, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliwia","family":"Wrotek","sequence":"additional","affiliation":[{"name":"Student Research Group, Bielanski Hospital, Ceg\u0142owska 80, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Jackowska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Centre of Postgraduate Medical Education, Marymoncka 99\/103, 01-813 Warsaw, Poland"},{"name":"Department of Pediatrics, Bielanski Hospital, Ceg\u0142owska 80, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1080\/14787210.2016.1227701","article-title":"Severe influenza in children: Incidence and risk factors","volume":"14","author":"Principi","year":"2016","journal-title":"Expert Rev. 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