{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:47:55Z","timestamp":1785332875315,"version":"3.55.0"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP\u2014Funda\u00e7\u00e3o de Amparo \u00e0 pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/18031-5"],"award-info":[{"award-number":["2015\/18031-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Secretariat of Economic development, Science, Technology and Innovation of S\u00e3o Paulo government, in Brazil","award":["2015\/18031-5"],"award-info":[{"award-number":["2015\/18031-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Repeated migraine attacks and aura could independently cause structural changes in the central nervous system. Our research aims to study the correlation of migraine type, attack frequency, and other clinical variables with the presence, volume and localization of white matter lesions (WML), in a controlled study. Methods: Sixty volunteers from a tertiary headache center were selected and divided equally into four groups: episodic migraine without aura (MoA), episodic migraine with aura (MA), chronic migraine (CM) and controls (CG). Voxel-based morphometry techniques were used to analyze WML. Results: There were no differences in WML variables between groups. There was a positive correlation between age and the number and total volume of WMLs, which persisted in the comparison categorized by size and brain lobe. Disease duration was positively correlated with the number and total volume of WML, and when controlled by age, the correlation maintained significance only for the insular lobe. Aura frequency was associated with frontal and temporal lobe WMLs. There was no statistically significant correlation between WML and other clinical variables. Conclusion: Migraine overall is not a risk factor for WML. Aura frequency is, however, associated with temporal WML. Disease duration, in adjusted analyses that account for age, is associated with insular WML.<\/jats:p>","DOI":"10.3390\/diagnostics13040799","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T05:57:52Z","timestamp":1676872672000},"page":"799","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["White Matter Lesions Identified by Magnetic Resonance in Women with Migraine: A Volumetric Analysis and Clinical Correlations"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2608-9184","authenticated-orcid":false,"given":"Nat\u00e1lia de Oliveira","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Neurosciences and Behavioral Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14015-010, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoly Machado","family":"Maciel","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14015-010, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"J\u00falio C\u00e9sar","family":"Nather","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14015-010, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Ferreira","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Institute of Health Sciences, University of Luebeck, 23562 Luebeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-2272","authenticated-orcid":false,"given":"Carina Ferreira","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14015-010, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Eduardo","family":"Bigal","sequence":"additional","affiliation":[{"name":"President and CEO, Ventus Therapeutics, Boston, MA 02453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Carlos dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14015-010, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Bevilaqua-Grossi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14015-010, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-4179","authenticated-orcid":false,"given":"Fabiola","family":"Dach","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Behavioral Sciences, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14015-010, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Waliszewska-Pros\u00f3\u0142, M., and Nowakowska-Kotas, M. 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