{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T08:00:20Z","timestamp":1764403220663,"version":"build-2065373602"},"reference-count":8,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007354","name":"Yen Tjing Ling Medical Foundation","doi-asserted-by":"publisher","award":["CI-111-26"],"award-info":[{"award-number":["CI-111-26"]}],"id":[{"id":"10.13039\/501100007354","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Chordoid meningioma (CM) makes up only 1% of all meningiomas. Most cases of this variant are locally aggressive, have high growth potential, and are likely to recur. Although CMs are known to be invasive, they rarely extend into the retro-orbital space. Herein, we report a case of a central skull base CM in a 78-year-old woman whose only manifestation was unilateral proptosis with impaired vision resulting from the tumor extending into the retro-orbital space through the superior orbital fissure. The diagnosis was confirmed by analysis of specimens collected during endoscopic orbital surgery, which simultaneously relieved the protruding eye and restored the patient\u2019s visual acuity by decompressing the oppressed orbit. This rare presentation of CM reminds physicians there may be lesions outside the orbit that can cause unilateral orbitopathy and that endoscopic orbital surgery can be used to confirm its diagnosis as well as treat it.<\/jats:p>","DOI":"10.3390\/diagnostics13050815","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T02:30:35Z","timestamp":1676946635000},"page":"815","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unilateral Orbitopathy Caused by Skull Base Chordoid Meningioma"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3898-5031","authenticated-orcid":false,"given":"Jia-He","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Syuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Jin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-0623","authenticated-orcid":false,"given":"Yu-Hsuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"},{"name":"Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.survophthal.2017.07.001","article-title":"A review of nasal, paranasal, and skull base tumors invading the orbit","volume":"63","author":"Heegaard","year":"2018","journal-title":"Surv. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s11060-015-1940-9","article-title":"Predictors of recurrence in the management of chordoid meningioma","volume":"126","author":"Choy","year":"2016","journal-title":"J. Neurooncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/1097-0142(19880715)62:2<391::AID-CNCR2820620226>3.0.CO;2-7","article-title":"\u201cChordoid\u201d meningeal tumors in young individuals with peritumoral lymphoplasmacellular infiltrates causing systemic manifestations of the Castleman syndrome. A report of seven cases","volume":"62","author":"Kepes","year":"1988","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/02688697.2020.1861436","article-title":"Chordoid meningioma: Report of 5 cases and review of the literature","volume":"37","author":"Tahta","year":"2020","journal-title":"Br. J. Neurosurg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3174\/ajnr.A4309","article-title":"Chordoid Meningioma: Differentiating a Rare World Health Organization Grade II Tumor from Other Meningioma Histologic Subtypes Using MRI","volume":"36","author":"Pond","year":"2015","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_6","first-page":"433","article-title":"Preoperative MR Imaging to Differentiate Chordoid Meningiomas from Other Meningioma Histologic Subtypes","volume":"40","author":"Baal","year":"2019","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/alr.21645","article-title":"Endoscopic endonasal orbital cavernous hemangioma resection: Global experience in techniques and outcomes","volume":"6","author":"Bleier","year":"2016","journal-title":"Int. Forum. Allergy Rhinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.3171\/2014.7.FOCUS14303","article-title":"Endoscopic endonasal optic nerve and orbital apex decompression for nontraumatic optic neuropathy: Surgical nuances and review of the literature","volume":"37","author":"Berhouma","year":"2014","journal-title":"Neurosurg. Focus"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/5\/815\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:37:45Z","timestamp":1760121465000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/5\/815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,21]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["diagnostics13050815"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13050815","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2023,2,21]]}}}