{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:31:59Z","timestamp":1790695919533,"version":"4.1.0"},"reference-count":55,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Radiomics refers to a recent area of knowledge that studies features extracted from different imaging techniques and subsequently transformed into high-dimensional data that can be associated with biological events. Diffuse midline gliomas (DMG) are one of the most devastating types of cancer, with a median survival of approximately 11 months after diagnosis and 4\u20135 months after radiological and clinical progression. Methods: A retrospective study. From a database of 91 patients with DMG, only 12 had the H3.3K27M mutation and brain MRI DICOM files available. Radiomic features were extracted from MRI T1 and T2 sequences using LIFEx software. Statistical analysis included normal distribution tests and the Mann\u2013Whitney U test, ROC analysis, and calculation of cut-off values. Results: A total of 5760 radiomic values were included in the analyses. AUROC demonstrated 13 radiomics with statistical significance for progression-free survival (PFS) and overall survival (OS). Diagnostic performance tests showed nine radiomics with specificity for PFS above 90% and one with a sensitivity of 97.2%. For OS, 3 out of 4 radiomics demonstrated between 80 and 90% sensitivity. Conclusions: Several radiomic features demonstrated statistical significance and have the potential to further aid DMG diagnostic assessment non-invasively. The most significant radiomics were first- and second-order features with GLCM texture profile, GLZLM_GLNU, and NGLDM_Contrast.<\/jats:p>","DOI":"10.3390\/diagnostics13050849","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T03:56:58Z","timestamp":1677124618000},"page":"849","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diagnostic Performance of Selected MRI-Derived Radiomics Able to Discriminate Progression-Free and Overall Survival in Patients with Midline Glioma and the H3F3AK27M Mutation"],"prefix":"10.3390","volume":"13","author":[{"given":"Maria-Fatima","family":"Chilaca-Rosas","sequence":"first","affiliation":[{"name":"Radiotherapy Department, Hospital de Oncolog\u00eda, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Garcia-Lezama","sequence":"additional","affiliation":[{"name":"Directorate of Research, Hospital General de Mexico \u201cDr Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Moreno-Jimenez","sequence":"additional","affiliation":[{"name":"Directorate of Surgery, Instituto Nacional de Neurolog\u00eda y Neurocirugia, \u201cManuel Velasco Suarez\u201d, Mexico City 14269, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-5289","authenticated-orcid":false,"given":"Ernesto","family":"Roldan-Valadez","sequence":"additional","affiliation":[{"name":"Directorate of Research, Hospital General de Mexico \u201cDr Eduardo Liceaga\u201d, Mexico City 06720, Mexico"},{"name":"Department of Radiology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Di Ruscio, V., Del Baldo, G., Fabozzi, F., Vinci, M., Cacchione, A., de Billy, E., Megaro, G., Carai, A., and Mastronuzzi, A. (2022). Pediatric Diffuse Midline Gliomas: An Unfinished Puzzle. 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