{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:17:17Z","timestamp":1778692637835,"version":"3.51.4"},"reference-count":130,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>A wide range of histological as well as clinical properties are exhibited by B-cell non-Hodgkin\u2019s lymphomas. These properties could make the diagnostics process complicated. The diagnosis of lymphomas at an initial stage is essential because early remedial actions taken against destructive subtypes are commonly deliberated as successful and restorative. Therefore, better protective action is needed to improve the condition of those patients who are extensively affected by cancer when diagnosed for the first time. The development of new and efficient methods for early detection of cancer has become crucial nowadays. Biomarkers are urgently needed for diagnosing B-cell non-Hodgkin\u2019s lymphoma and assessing the severity of the disease and its prognosis. New possibilities are now open for diagnosing cancer with the help of metabolomics. The study of all the metabolites synthesised in the human body is called \u201cmetabolomics.\u201d A patient\u2019s phenotype is directly linked with metabolomics, which can help in providing some clinically beneficial biomarkers and is applied in the diagnostics of B-cell non-Hodgkin\u2019s lymphoma. In cancer research, it can analyse the cancerous metabolome to identify the metabolic biomarkers. This review provides an understanding of B-cell non-Hodgkin\u2019s lymphoma metabolism and its applications in medical diagnostics. A description of the workflow based on metabolomics is also provided, along with the benefits and drawbacks of various techniques. The use of predictive metabolic biomarkers for the diagnosis and prognosis of B-cell non-Hodgkin\u2019s lymphoma is also explored. Thus, we can say that abnormalities related to metabolic processes can occur in a vast range of B-cell non-Hodgkin\u2019s lymphomas. The metabolic biomarkers could only be discovered and identified as innovative therapeutic objects if we explored and researched them. In the near future, the innovations involving metabolomics could prove fruitful for predicting outcomes and bringing out novel remedial approaches.<\/jats:p>","DOI":"10.3390\/diagnostics13050861","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T03:01:01Z","timestamp":1677207661000},"page":"861","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin\u2019s Lymphoma"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0747-9451","authenticated-orcid":false,"given":"Abdullah","family":"Alfaifi","sequence":"first","affiliation":[{"name":"Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"},{"name":"Fayfa General Hospital, Ministry of Health, Jazan 83581, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6590-5594","authenticated-orcid":false,"given":"Mohammed Y.","family":"Refai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Science, University of Jeddah, Jeddah 21493, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Alsaadi","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"},{"name":"Hematology Research Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salem","family":"Bahashwan","sequence":"additional","affiliation":[{"name":"Hematology Research Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia"},{"name":"Department of Hematology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia"},{"name":"King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-9769","authenticated-orcid":false,"given":"Hafiz","family":"Malhan","sequence":"additional","affiliation":[{"name":"Prince Mohammed Bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waiel","family":"Al-Kahiry","sequence":"additional","affiliation":[{"name":"Prince Mohammed Bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enas","family":"Dammag","sequence":"additional","affiliation":[{"name":"Prince Mohammed Bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3058-1366","authenticated-orcid":false,"given":"Ageel","family":"Ageel","sequence":"additional","affiliation":[{"name":"Prince Mohammed Bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amjed","family":"Mahzary","sequence":"additional","affiliation":[{"name":"Eradah Hospital, Ministry of Health, Jazan 82943, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9739-5496","authenticated-orcid":false,"given":"Raed","family":"Albiheyri","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein","family":"Almehdar","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-0585","authenticated-orcid":false,"given":"Ishtiaq","family":"Qadri","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"ref_1","unstructured":"Szyma\u0144ska, K., and Park, S. 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