{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:53:57Z","timestamp":1787068437150,"version":"build-2736575974"},"reference-count":138,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The microbiota is the complex community of microorganisms that populate a particular environment in the human body, whereas the microbiome is defined by the entire habitat\u2014microorganisms and their environment. The most abundant and, therefore, the most studied microbiome is that of the gastrointestinal tract. However, the microbiome of the female reproductive tract is an interesting research avenue, and this article explores its role in disease development. The vagina is the reproductive organ that hosts the largest number of bacteria, with a healthy profile represented mainly by Lactobacillus spp. On the other hand, the female upper reproductive tract (uterus, Fallopian tubes, ovaries) contains only a very small number of bacteria. Previously considered sterile, recent studies have shown the presence of a small microbiota here, but there are still debates on whether this is a physiologic or pathologic occurrence. Of particular note is that estrogen levels significantly influence the composition of the microbiota of the female reproductive tract. More and more studies show a link between the microbiome of the female reproductive tract and the development of gynecological cancers. This article reviews some of these findings.<\/jats:p>","DOI":"10.3390\/diagnostics13050877","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T04:13:16Z","timestamp":1677471196000},"page":"877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Female Reproductive Tract Microbiome and Cancerogenesis: A Review Story of Bacteria, Hormones, and Disease"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9566-7067","authenticated-orcid":false,"given":"Oana Gabriela","family":"Trifanescu","sequence":"first","affiliation":[{"name":"Department of Oncology, \u201eCarol Davila\u201d University of Medicine and Pharmacy, 022328 Bucharest, Romania"},{"name":"2nd Department of Radiotherapy, \u201eProf. Dr. Al. Trestioreanu\u201d Institute of Oncology, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca Alexandra","family":"Trifanescu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 011863 Bucharest, Romania"},{"name":"\u201cC.I. Parhon\u201d Institute of Endocrinology, 011863 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0454-0453","authenticated-orcid":false,"given":"Radu Iulian","family":"Mitrica","sequence":"additional","affiliation":[{"name":"Department of Oncology, \u201eCarol Davila\u201d University of Medicine and Pharmacy, 022328 Bucharest, Romania"},{"name":"2nd Department of Radiotherapy, \u201eProf. Dr. Al. Trestioreanu\u201d Institute of Oncology, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Maria","family":"Bran","sequence":"additional","affiliation":[{"name":"2nd Department of Radiotherapy, \u201eProf. Dr. Al. Trestioreanu\u201d Institute of Oncology, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia Luiza","family":"Serbanescu","sequence":"additional","affiliation":[{"name":"Department of Oncology, \u201eCarol Davila\u201d University of Medicine and Pharmacy, 022328 Bucharest, Romania"},{"name":"2nd Department of Radiotherapy, \u201eProf. Dr. Al. Trestioreanu\u201d Institute of Oncology, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurentiu","family":"Valcauan","sequence":"additional","affiliation":[{"name":"2nd Department of Radiotherapy, \u201eProf. Dr. Al. Trestioreanu\u201d Institute of Oncology, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serban Andrei","family":"Marinescu","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201eProf. Dr. Al. Trestioreanu\u201d Institute of Oncology, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-1607","authenticated-orcid":false,"given":"Laurentia Nicoleta","family":"Gales","sequence":"additional","affiliation":[{"name":"Department of Oncology, \u201eCarol Davila\u201d University of Medicine and Pharmacy, 022328 Bucharest, Romania"},{"name":"2nd Department of Oncology, \u201eProf. Dr. Al. Trestioreanu\u201d Institute of Oncology, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan Cosmin","family":"Tanase","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, \u201cProf. Dr. Al. Trestioreanu\u201d Institute of Oncology, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodica Maricela","family":"Anghel","sequence":"additional","affiliation":[{"name":"Department of Oncology, \u201eCarol Davila\u201d University of Medicine and Pharmacy, 022328 Bucharest, Romania"},{"name":"2nd Department of Radiotherapy, \u201eProf. Dr. Al. 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