{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:23:32Z","timestamp":1791933812120,"version":"4.3.4"},"reference-count":77,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: The prevalence of aspergillus sensitization (AS) and allergic bronchopulmonary aspergillosis (ABPA) in asthmatic children remains unclear. Objective: To systematically review the literature to estimate the prevalence of AS and ABPA in children with bronchial asthma. Methods: We searched the PubMed and Embase databases for studies reporting the prevalence of AS or ABPA in pediatric asthma. The primary outcome was to assess the prevalence of AS, while the secondary outcome was to evaluate the prevalence of ABPA. We pooled the prevalence estimates using a random effects model. We also calculated the heterogeneity and publication bias. Results: Of the 11,695 records retrieved, 16 studies with 2468 asthmatic children met the inclusion criteria. Most studies were published from tertiary centers. The pooled prevalence of AS in asthma (15 studies; 2361 subjects) was 16.1% (95% confidence intervals [CI], 9.3\u201324.3). The prevalence of AS was significantly higher in prospective studies, studies from India, and those from developing countries. The pooled prevalence of ABPA in asthma (5 studies; 505 children) was 9.9% (95% CI, 0.81\u201327.6). There was significant heterogeneity and publication bias for both outcomes. Conclusions: We found a high prevalence of AS and ABPA in asthmatic children. There is a need for community-based studies from different ethnicities using a standard methodology to ascertain the true prevalence of AS and ABPA in pediatric asthma.<\/jats:p>","DOI":"10.3390\/diagnostics13050922","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T03:03:48Z","timestamp":1677639828000},"page":"922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Aspergillus Sensitization and Allergic Bronchopulmonary Aspergillosis in Asthmatic Children: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2547-7668","authenticated-orcid":false,"given":"Ritesh","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valliappan","family":"Muthu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderpaul Singh","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahajal","family":"Dhooria","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuruswamy Thurai","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4839-0138","authenticated-orcid":false,"given":"Kathirvel","family":"Soundappan","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-9253","authenticated-orcid":false,"given":"Shivaprakash Mandya","family":"Rudramurthy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh Nath","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-3807","authenticated-orcid":false,"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Doodhadhari Burfani Hospital, Haridwar 249411, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5334\/aogh.2416","article-title":"Pediatric Asthma: A Global Epidemic","volume":"85","author":"Serebrisky","year":"2019","journal-title":"Ann. Glob. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990\u20132010: A systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1365-2222.1998.028s5052.x","article-title":"The International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Steering Committee","volume":"28","author":"Asher","year":"1998","journal-title":"Clin. Exp. Allergy"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.aller.2012.03.001","article-title":"The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three: A global synthesis","volume":"41","author":"Mallol","year":"2013","journal-title":"Allergol. Immunopathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1183\/13993003.00780-2015","article-title":"The burden of severe asthma in childhood and adolescence: Results from the paediatric U-BIOPRED cohorts","volume":"46","author":"Fleming","year":"2015","journal-title":"Eur. Respir. J."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bush, A. (2020). Kids, Difficult Asthma and Fungus. J. Fungi, 6.","DOI":"10.3390\/jof6020055"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jaci.2010.11.037","article-title":"Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome","volume":"127","author":"Akdis","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/cea.12848","article-title":"The relationship between biomarkers of fungal allergy and lung damage in asthma","volume":"47","author":"Woolnough","year":"2017","journal-title":"Clin. Exp. Allergy"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/cea.13799","article-title":"Fungal sensitization and positive fungal culture from sputum in children with asthma are associated with reduced lung function and acute asthma attacks respectively","volume":"51","author":"Welsh","year":"2021","journal-title":"Clin. Exp. Allergy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/MCP.0000000000000129","article-title":"Allergic fungal airway disease: Pathophysiologic and diagnostic considerations","volume":"21","author":"Woolnough","year":"2015","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s11882-011-0217-4","article-title":"Severe asthma with fungal sensitization","volume":"11","author":"Agarwal","year":"2011","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0954-6111(94)90035-3","article-title":"A new look at the natural history of Aspergillus hypersensitivity in asthmatics","volume":"88","author":"Bateman","year":"1994","journal-title":"Respir. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.3109\/13693786.2010.504752","article-title":"Severe asthma and fungi: Current evidence","volume":"49","author":"Agarwal","year":"2011","journal-title":"Med. Mycol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.4103\/lungindia.lungindia_216_18","article-title":"Childhood allergic bronchopulmonary aspergillosis","volume":"35","author":"Jat","year":"2018","journal-title":"Lung India"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"582964","DOI":"10.3389\/fped.2020.582964","article-title":"Current Approach in the Diagnosis and Management of Allergic Bronchopulmonary Aspergillosis in Children with Cystic Fibrosis","volume":"8","author":"Sunman","year":"2020","journal-title":"Front. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3109\/1040841X.2012.754401","article-title":"Allergic bronchopulmonary mycosis due to fungi other than Aspergillus: A global overview","volume":"40","author":"Chowdhary","year":"2014","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ccm.2021.12.002","article-title":"Allergic Bronchopulmonary Aspergillosis","volume":"43","author":"Agarwal","year":"2022","journal-title":"Clin. Chest Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.7326\/0003-4819-86-4-405","article-title":"Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis","volume":"86","author":"Rosenberg","year":"1977","journal-title":"Ann. Intern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/cea.12141","article-title":"Allergic bronchopulmonary aspergillosis: Review of literature and proposal of new diagnostic and classification criteria","volume":"43","author":"Agarwal","year":"2013","journal-title":"Clin. Exp. Allergy"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Agarwal, R., Maskey, D., Aggarwal, A.N., Saikia, B., Garg, M., Gupta, D., and Chakrabarti, A. (2013). Diagnostic performance of various tests and criteria employed in allergic bronchopulmonary aspergillosis: A latent class analysis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061105"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jaip.2020.08.043","article-title":"Which Are the Optimal Criteria for the Diagnosis of Allergic Bronchopulmonary Aspergillosis? A Latent Class Analysis","volume":"9","author":"Saxena","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/myc.12541","article-title":"Role of Aspergillus fumigatus-specific IgG in diagnosis and monitoring treatment response in allergic bronchopulmonary aspergillosis","volume":"60","author":"Agarwal","year":"2017","journal-title":"Mycoses"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/myc.13488","article-title":"Comparative diagnostic accuracy of immunoprecipitation versus immunoassay methods for detecting Aspergillus fumigatus-specific IgG in allergic bronchopulmonary aspergillosis: A systematic review and meta-analysis","volume":"65","author":"Sehgal","year":"2022","journal-title":"Mycoses"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.jaci.2020.08.029","article-title":"New clinical diagnostic criteria for allergic bronchopulmonary aspergillosis\/mycosis and its validation","volume":"147","author":"Asano","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.anai.2013.06.022","article-title":"Dissociation between sensitizing and colonizing fungi in patients with allergic bronchopulmonary aspergillosis","volume":"111","author":"Matsuse","year":"2013","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2217\/fmb.13.116","article-title":"Allergic bronchopulmonary aspergillosis in asthma: Epidemiological, clinical and therapeutic issues","volume":"8","author":"Agarwal","year":"2013","journal-title":"Future Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"ref_28","unstructured":"Wells, G., Shea, B., O\u2019Connell, D., Peterson, J.W., Welch, V., Losos, M., and Tugwell, P. (2020, September 30). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta-Analyses. Available online: http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Modesti, P.A., Reboldi, G., Cappuccio, F.P., Agyemang, C., Remuzzi, G., Rapi, S., Perruolo, E., and Parati, G. (2016). Panethnic Differences in Blood Pressure in Europe: A Systematic Review and Meta-Analysis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0147601"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<857::AID-SIM777>3.0.CO;2-E","article-title":"Two-sided confidence intervals for the single proportion: A comparative evaluation of seven methods","volume":"17","author":"Newcombe","year":"1998","journal-title":"Stat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1214\/aoms\/1177729756","article-title":"Transformations Related to the Angular and the Square Root","volume":"21","author":"Freeman","year":"1950","journal-title":"Ann. Math. Stat."},{"key":"ref_32","first-page":"138","article-title":"The Inverse of the Freeman-Tukey Double Arcsine Transformation","volume":"32","author":"Miller","year":"1978","journal-title":"Am. Stat."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin. Trials"},{"key":"ref_34","unstructured":"Alderson, P., Green, S., and Higgins, J.P.T. (2004). Cochrane Reviewers\u2019 Handbook 4.2.2, John Wiley & Sons, Ltd.. Updated March 2004."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1002\/sim.2380","article-title":"A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints","volume":"25","author":"Harbord","year":"2006","journal-title":"Stat. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"ref_38","unstructured":"(2022, December 28). Developing Countries. Available online: https:\/\/www.worlddata.info\/developing-countries.php."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1378\/chest.63.2.177","article-title":"Allergic bronchopulmonary aspergillosis is not rare. With a note on preparation of antigen for immunologic tests","volume":"63","author":"Hoehne","year":"1973","journal-title":"Chest"},{"key":"ref_40","first-page":"46","article-title":"Allergic bronchopulmonary aspergillosis in Indian children with bronchial asthma","volume":"54","author":"Chetty","year":"1985","journal-title":"Ann. Allergy"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1398-9995.1991.tb00549.x","article-title":"Use of the extended Phadebas RAST panel in the diagnosis of mould allergy in asthmatic children","volume":"46","author":"Koivikko","year":"1991","journal-title":"Allergy"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1442-200X.2006.02275.x","article-title":"Skin test reactivity to molds in pre-school children with newly diagnosed asthma","volume":"48","author":"Korhonen","year":"2006","journal-title":"Pediatr. Int."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/j.1398-9995.2010.02382.x","article-title":"Mold-sensitivity in children with moderate-severe asthma is associated with HLA-DR and HLA-DQ","volume":"65","author":"Knutsen","year":"2010","journal-title":"Allergy"},{"key":"ref_44","first-page":"328","article-title":"Prevalence of mold allergy in asthmatic patients of less than 18 years old in Semnan","volume":"17","author":"Nabavi","year":"2010","journal-title":"J. Kerman Univ. Med. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jaip.2013.06.013","article-title":"The relationship between a specific IgE level and asthma outcomes: Results from the 2005-2006 National Health and Nutrition Examination Survey","volume":"1","author":"Arroyave","year":"2013","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ppul.22779","article-title":"Fungal sensitization in childhood persistent asthma is associated with disease severity","volume":"49","author":"Vicencio","year":"2014","journal-title":"Pediatr. Pulmonol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e206","DOI":"10.1111\/apa.12930","article-title":"The diagnostic criteria for allergic bronchopulmonary aspergillosis in children with poorly controlled asthma need to be re-evaluated","volume":"104","author":"Singh","year":"2015","journal-title":"Acta Paediatr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/1658-631X.204876","article-title":"Sensitization to Common Aeroallergens in Asthmatic Children in the Eastern Region of Saudi Arabia","volume":"5","author":"AlKhater","year":"2017","journal-title":"Saudi J. Med. Med. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4168\/aair.2017.9.6.509","article-title":"Association Between Sensitization to Mold and Impaired Pulmonary Function in Children with Asthma","volume":"9","author":"Byeon","year":"2017","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1753465816680786","article-title":"Clinical relevance of IgE-mediated sensitization against the mould Alternaria alternata in children with asthma","volume":"11","author":"Lehmann","year":"2017","journal-title":"Ther. Adv. Respir. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/myc.12726","article-title":"Correlation between fungal sensitisation in childhood persistent asthma and disease severity","volume":"61","author":"Gupta","year":"2018","journal-title":"Mycoses"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"100115","DOI":"10.1016\/j.waojou.2020.100115","article-title":"Prevalence of common sensitizing aeroallergens in Egyptian asthmatic patients","volume":"13","author":"Ishak","year":"2020","journal-title":"World Allergy Organ J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/tropej\/fmz066","article-title":"Prevalence and Risk Factors of Allergic Bronchopulmonary Aspergillosis and Aspergillus Sensitization in Children with Poorly Controlled Asthma","volume":"66","author":"Kumari","year":"2020","journal-title":"J. Trop. Pediatr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jaip.2014.06.022","article-title":"Severe asthma in children","volume":"2","author":"Guilbert","year":"2014","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1513\/AnnalsATS.201708-637FR","article-title":"A Practical Approach to Severe Asthma in Children","volume":"15","author":"Barsky","year":"2018","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.alit.2018.11.007","article-title":"Severe asthma in children: Evaluation and management","volume":"68","author":"Phipatanakul","year":"2019","journal-title":"Allergol. Int."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1183\/09031936.00104809","article-title":"Problematic severe asthma in children, not one problem but many: A GA2LEN initiative","volume":"36","author":"Hedlin","year":"2010","journal-title":"Eur. Respir. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s11046-014-9767-z","article-title":"Burden and distinctive character of allergic bronchopulmonary aspergillosis in India","volume":"178","author":"Agarwal","year":"2014","journal-title":"Mycopathologia"},{"key":"ref_59","first-page":"232","article-title":"Prevalence of fungal spores in rural and urban environments of Pondicherry region during 2013","volume":"5","author":"Nayak","year":"2014","journal-title":"Adv. Appl. Sci. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11882-013-0343-2","article-title":"Racial differences in allergic sensitization: Recent findings and future directions","volume":"13","author":"Wegienka","year":"2013","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1111\/all.13566","article-title":"De novo sensitization to Aspergillus fumigatus in adult asthma over a 10-year observation period","volume":"73","author":"Watai","year":"2018","journal-title":"Allergy"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1159\/000512230","article-title":"Sensitization against Fungi in Patients with Airway Allergies over 20 Years in Germany","volume":"182","author":"Forkel","year":"2021","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4103\/lungindia.lungindia_706_21","article-title":"Prevalence of asthma among children in India: A systematic review and meta-analysis","volume":"39","author":"Daniel","year":"2022","journal-title":"Lung India"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s13312-014-0396-x","article-title":"Prevalence and risk factors for allergic bronchopulmonary aspergillosis in Indian children with cystic fibrosis","volume":"51","author":"Sharma","year":"2014","journal-title":"Indian Pediatr."},{"key":"ref_65","first-page":"37","article-title":"Cystic fibrosis in low and middle-income countries (LMIC): A view from four different regions of the world","volume":"38","author":"Zampoli","year":"2021","journal-title":"Paediatr. Respir. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11046-022-00631-y","article-title":"Occurrence of Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations in Patients with Allergic Bronchopulmonary Aspergillosis Complicating Asthma","volume":"187","author":"Kanaujia","year":"2022","journal-title":"Mycopathologia"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2169\/internalmedicine.40.522","article-title":"The spectrum of CFTR-related disease","volume":"40","author":"Boyle","year":"2001","journal-title":"Intern. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1439-0507.2011.02130.x","article-title":"Link between CFTR mutations and ABPA: A systematic review and meta-analysis","volume":"55","author":"Agarwal","year":"2012","journal-title":"Mycoses"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1378\/chest.07-0808","article-title":"Clinical significance of hyperattenuating mucoid impaction in allergic bronchopulmonary aspergillosis: An analysis of 155 patients","volume":"132","author":"Agarwal","year":"2007","journal-title":"Chest"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4103\/0971-3026.90680","article-title":"Pictorial essay: Allergic bronchopulmonary aspergillosis","volume":"21","author":"Agarwal","year":"2011","journal-title":"Indian J. Radiol. Imaging"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/thx.2008.106609","article-title":"Global variation in the prevalence and severity of asthma symptoms: Phase three of the International Study of Asthma and Allergies in Childhood (ISAAC)","volume":"64","author":"Lai","year":"2009","journal-title":"Thorax"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1164\/rccm.200805-737OC","article-title":"Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study","volume":"179","author":"Denning","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1378\/chest.15-0069","article-title":"Specific IgE is better than skin testing for detecting Aspergillus sensitization and allergic bronchopulmonary aspergillosis in asthma","volume":"147","author":"Sehgal","year":"2015","journal-title":"Chest"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1801269","DOI":"10.1183\/13993003.01269-2018","article-title":"Treatable traits in bronchiectasis","volume":"52","author":"Boaventura","year":"2018","journal-title":"Eur. Respir. J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/resp.13509","article-title":"Pathophysiology, causes and genetics of paediatric and adult bronchiectasis","volume":"24","author":"Bush","year":"2019","journal-title":"Respirology"},{"key":"ref_76","unstructured":"Wilson, J.M.G., and Junger, G. (1968). Principles and Practice of Screening for Disease, World Health Organization."},{"key":"ref_77","first-page":"936","article-title":"Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: Systematic review and meta-analysis","volume":"13","author":"Agarwal","year":"2009","journal-title":"Int. J. Tuberc. Lung Dis."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/5\/922\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:44:53Z","timestamp":1760121893000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/5\/922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":77,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["diagnostics13050922"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13050922","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,1]]}}}