{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:59:23Z","timestamp":1760147963240,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00741","JR19\/00006","CM20\/00171","RD21\/0012\/0012"],"award-info":[{"award-number":["PI20\/00741","JR19\/00006","CM20\/00171","RD21\/0012\/0012"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Recovery, Transformation and Resilience Plan 2017\u20132020, ISCIII","award":["PI20\/00741","JR19\/00006","CM20\/00171","RD21\/0012\/0012"],"award-info":[{"award-number":["PI20\/00741","JR19\/00006","CM20\/00171","RD21\/0012\/0012"]}]},{"DOI":"10.13039\/501100004587","name":"European Union\u2013Next Generation EU","doi-asserted-by":"publisher","award":["PI20\/00741","JR19\/00006","CM20\/00171","RD21\/0012\/0012"],"award-info":[{"award-number":["PI20\/00741","JR19\/00006","CM20\/00171","RD21\/0012\/0012"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Introduction: Suspected preterm labor (SPL), defined as the presence of regular and painful uterine contractions and cervical shortening, represents a prenatal insult with potential long-term consequences. However, despite recent evidence demonstrating suboptimal neurodevelopment at 2 years in this population, it remains underestimated as a significant risk factor for neurodevelopmental disorders or other chronic diseases. The aim of this study is to assess the impact of suspected preterm labor during pregnancy on cardiometabolic profile and neurodevelopment during childhood (6\u20138 years). Methods and analysis: Prospective cohort study including children whose mothers suffered suspected preterm labour during pregnancy and paired controls. Neurodevelopmental, cardiovascular, and metabolic assessments will be performed at 6\u20138 years of age. A trained psychologist will carry out the neurodevelopment assessment including intelligence, visual perception, and behavioral assessment. Body composition and physical fitness assessment will be performed by one trained pediatrician and nurse. Finally, cardiovascular evaluation, including echocardiography and blood pressure, will be performed by two pediatric cardiologists. Data regarding perinatal and postnatal characteristics, diet, lifestyle, and weekly screen time of the child will be obtained from medical history and direct interviews with families. Primary outcome measures will include body mass index and adiposity, percentage of fat mass and total and regional lean mass, bone mineral content and density, cardiorespiratory resistance, isometric muscle strength, dynamic lower body strength, systolic and diastolic blood pressure, left ventricle (LV) systolic and diastolic function, general intelligence index, visuospatial working memory span, oculomotor control test, index of emotional, and behavioral problems.<\/jats:p>","DOI":"10.3390\/diagnostics13061101","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T04:39:45Z","timestamp":1678855185000},"page":"1101","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Suspected Preterm Labor during Pregnancy on Cardiometabolic Profile and Neurodevelopment during Childhood: A Prospective Cohort Study Protocol"],"prefix":"10.3390","volume":"13","author":[{"given":"Jes\u00fas","family":"Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Pediatrics Department, Quir\u00f3nsalud Hospital Zaragoza, 50006 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Vilella","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Aragon), 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Aragon), 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-3646","authenticated-orcid":false,"given":"Iris","family":"Iglesia","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Aragon), 50009 Zaragoza, Spain"},{"name":"Red RICORS \u201cPrimary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin\u201d, RD21\/0012\/0001, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon IA2 Universidad de Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Clavero-Adell","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Aragon), 50009 Zaragoza, Spain"},{"name":"Paediatric Cardiology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Cardiovascular (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-8137","authenticated-orcid":false,"given":"Ariadna","family":"Ayerza-Casas","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Aragon), 50009 Zaragoza, Spain"},{"name":"Paediatric Cardiology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-1667","authenticated-orcid":false,"given":"Angel","family":"Matute-Llorente","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Aragon), 50009 Zaragoza, Spain"},{"name":"Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragon IA2 Universidad de Zaragoza, 50009 Zaragoza, Spain"},{"name":"Department of Physiatry and Nursing, Faculty of Health and Sport Sciences (FCSD), University of Zaragoza, 22001 Huesca, Spain"},{"name":"Physiopathology of Obesity and Nutrition Networking Biomedical Research Center (CIBERObn), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Oros","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Aragon), 50009 Zaragoza, Spain"},{"name":"Red RICORS \u201cPrimary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin\u201d, RD21\/0012\/0001, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Obstetrics Department, Hospital Cl\u00ednico Universitario Lozano Blesa Zaragoza, University of Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7215-6931","authenticated-orcid":false,"given":"Jose Antonio","family":"Casaj\u00fas","sequence":"additional","affiliation":[{"name":"Instituto de 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