{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:59:00Z","timestamp":1760147940904,"version":"build-2065373602"},"reference-count":18,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The clear-cell variant of epithelioid mesothelioma is an extremely rare neoplasm of the peritoneum. It shares histomorphologic features overlapping with a wide variety of tumors including carcinomas and other non-epithelial neoplasms. The diagnosis of peritoneal clear-cell mesothelioma is not always straightforward, despite known immunohistochemistry (IHC) markers. Due to its rarity, this entity may be diagnostically confused with other clear-cell neoplasms, particularly in intraoperative frozen sections. Here, we present a case of clear-cell mesothelioma originating in the uterine serosa that was initially misdiagnosed as clear-cell adenocarcinoma in the intraoperative frozen section. Microscopically, the tumor showed diffuse tubulocystic spaces of variable size lined by clear cells with moderate nuclear atypia. Immunohistochemical staining confirmed the diagnosis of clear-cell mesothelioma. Recognition of this entity, albeit rare, is important as the diagnosis may significantly affect the management considerations. The judicious use of an IHC panel helps to distinguish this tumor from other mimickers.<\/jats:p>","DOI":"10.3390\/diagnostics13061119","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T02:40:11Z","timestamp":1678934411000},"page":"1119","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clear-Cell Mesothelioma of Uterine Corpus: Diagnostic Challenges in Intraoperative Frozen Sections"],"prefix":"10.3390","volume":"13","author":[{"given":"Tip","family":"Pongsuvareeyakul","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9996-1933","authenticated-orcid":false,"given":"Kanokkan","family":"Saipattranusorn","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chonburi Hospital, Chonburi 20000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kornkanok","family":"Sukpan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prapaporn","family":"Suprasert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surapan","family":"Khunamornpong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/PAS.0000000000001418","article-title":"Malignant Diffuse Mesothelioma in Women: A Study of 354 Cases","volume":"44","author":"Pavlisko","year":"2020","journal-title":"Am. 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Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41379-020-00688-4","article-title":"Malignant peritoneal mesothelioma: Prognostic significance of clinical and pathologic parameters and validation of a nuclear-grading system in a multi-institutional series of 225 cases","volume":"34","author":"Chapel","year":"2021","journal-title":"Mod. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.humpath.2018.07.033","article-title":"Primary peritoneal epithelioid mesothelioma of clear cell type with a novel VHL gene mutation: A case report","volume":"83","author":"Naous","year":"2019","journal-title":"Hum. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1097\/PAS.0000000000001924","article-title":"Localized Malignant Peritoneal Mesothelioma (LMPeM) in Women: A Clinicopathologic Study of 18 Cases","volume":"46","author":"Malpica","year":"2022","journal-title":"Am. J. Surg. 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Oncol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"613099","DOI":"10.3389\/pore.2021.613099","article-title":"Napsin A Expression in Human Tumors and Normal Tissues","volume":"27","author":"Weidemann","year":"2021","journal-title":"Pathol. Oncol. Res."},{"key":"ref_17","unstructured":"Gilk, B. (2020). WHO Classification of Femal Genital Tumours, International Agency for Research on Cancer (IARC). [5th ed.]."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41379-019-0352-3","article-title":"Localized malignant mesothelioma, an unusual and poorly characterized neoplasm of serosal origin: Best current evidence from the literature and the International Mesothelioma Panel","volume":"33","author":"Marchevsky","year":"2020","journal-title":"Mod. Pathol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/6\/1119\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:56:06Z","timestamp":1760122566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/6\/1119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,15]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["diagnostics13061119"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13061119","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2023,3,15]]}}}