{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:02:13Z","timestamp":1760148133649,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH CORE","doi-asserted-by":"publisher","award":["P30 EY08098"],"award-info":[{"award-number":["P30 EY08098"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Optical coherence tomography angiography (OCTA) is a noninvasive imaging modality used to analyze the retinochoroidal vasculature and detect vascular flow. The resulting images can be segmented to view each vascular plexus individually. While fluorescein angiography is still the gold standard for the diagnosis of posterior uveitis, it has limitations, and can be replaced by OCTA in some cases. Methods: This case series describes five patients with posterior noninfectious uveitis and their description by OCTA. Results: Cases included lupus retinopathy (n = 1) for which OCTA showed ischemic maculopathy as areas of flow deficit at the superficial and deep capillary plexus; choroidal granulomas (n = 1) with a non-detectable flow signal in the choroid; active punctate inner choroiditis and multifocal choroiditis (n = 1) with OCTA that showed active inflammatory chorioretinal lesions as non-detectable flow signals in choriocapillaris and choroid; dense type 2 inflammatory secondary neovascularization (n = 1) associated with active choroiditis; and acute posterior multifocal placoid pigment epitheliopathy (APMPPE) (n = 1) without flow abnormalities at the superficial and deep retinal plexuses but non-detectable flow at the levels of the choriocapillaris and choroid. Conclusions: Ophthalmologists can use OCTA to identify inflammatory changes in retinal and choroidal vasculature, aiding in the diagnosis, management, and monitoring of posterior uveitis.<\/jats:p>","DOI":"10.3390\/diagnostics13071296","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T03:17:35Z","timestamp":1680146255000},"page":"1296","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["OCT Angiography in Noninfectious Uveitis: A Description of Five Cases and Clinical Applications"],"prefix":"10.3390","volume":"13","author":[{"given":"Samyuktha","family":"Melachuri","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunal K.","family":"Dansingani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Wesalo","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Paez-Escamilla","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghal","family":"Gagrani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4175-6504","authenticated-orcid":false,"given":"Sarah","family":"Atta","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Indermill","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9-Alain","family":"Sahel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken K.","family":"Nischal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1772-3558","authenticated-orcid":false,"given":"Jay","family":"Chhablani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Errera","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12348-019-0176-9","article-title":"Optical coherence tomography angiography (OCTA) as a new diagnostic tool in uveitis","volume":"9","author":"Dingerkus","year":"2019","journal-title":"J. Ophthalmic Inflamm. Infect."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1364\/BOE.10.003560","article-title":"High dynamic range optical coherence tomography angiography (HDR-OCTA)","volume":"10","author":"Wei","year":"2019","journal-title":"Biomed. Opt. Express"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1080\/09273948.2022.2071743","article-title":"The Role of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Differential Diagnosis of Posterior Uveitis","volume":"30","author":"Agarwal","year":"2022","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1097\/IAE.0000000000001255","article-title":"En face optical coherence tomography and optical coherence tomography angiography of multiple evanescent white dot syndrome: New insights into pathogenesis","volume":"36","author":"Pichi","year":"2016","journal-title":"Retina"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1097\/IAE.0000000000003420","article-title":"Role of optical coherence tomography angiography in detecting and monitoring inflammatory choroidal neovascularization","volume":"42","author":"Kongwattananon","year":"2022","journal-title":"Retina"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1080\/09273948.2020.1837185","article-title":"Review of the Current Literature and Our Experience on the Value of OCT-angiography in White Dot Syndromes","volume":"30","author":"Terrada","year":"2022","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/IAE.0000000000002864","article-title":"Choroidal granulomas visualized by swept-source optical coherence tomography angiography","volume":"41","author":"Pichi","year":"2021","journal-title":"Retina"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1097\/IAE.0000000000000842","article-title":"Real-Time Full-Depth Visualization of Posterior Ocular Structures: Comparison between Full-Depth Imaging Spectral Domain Optical Coherence Tomography and Swept-Source Optical Coherence Tomography","volume":"36","author":"Barteselli","year":"2016","journal-title":"Retina"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ajo.2020.05.006","article-title":"Quantitative Analysis of the Choriocapillaris in Uveitis Using En Face Swept-Source Optical Coherence Tomography Angiography","volume":"218","author":"Chu","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12348-019-0184-9","article-title":"The broad spectrum of application of optical coherence tomography angiography to the anterior segment of the eye in inflammatory conditions: A review of the literature","volume":"9","author":"Pichi","year":"2019","journal-title":"J. Ophthalmic Inflamm. Infect."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pichi, F., Carre\u00f1o, E., Pavesio, C., Denniston, A.K., Grewal, D.S., Deak, G., Khairallah, M., Ruiz-Cruz, M., de Oliveira Dias, J.R., and Adan, A. (2022). Consensus-based recommendations for optical coherence tomography angiography reporting in uveitis. Br. J. Ophthalmol.","DOI":"10.1136\/bjophthalmol-2021-320021"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ajo.2005.03.057","article-title":"Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop","volume":"140","author":"Jabs","year":"2005","journal-title":"Am. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Standardization of Uveitis Nomenclature (SUN) Working Group (2021). Development of Classification Criteria for the Uveitides. Am. J. Ophthalmol., 228, 96\u2013105.","DOI":"10.1016\/j.ajo.2021.03.061"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/ceo.13470","article-title":"Optical coherence tomography and optical coherence tomography angiography in uveitis: A review","volume":"47","author":"Invernizzi","year":"2019","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.ophtha.2014.03.011","article-title":"Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography","volume":"121","author":"Keane","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4103\/0974-9233.58422","article-title":"Inflammatory choroidal neovascularization","volume":"16","author":"Neri","year":"2009","journal-title":"Middle East Afr. J. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/S0161-6420(96)30561-7","article-title":"Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome","volume":"103","author":"Brown","year":"1996","journal-title":"Ophthalmology"},{"key":"ref_18","first-page":"118","article-title":"Inflammatory Choroidal Neovascular Membranes in Patients with Noninfectious Uveitis: The Place of Intravitreal Anti-VEGF Therapy","volume":"9","author":"Karti","year":"2020","journal-title":"Med. Hypothesis Discov. Innov. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1177\/1120672117753704","article-title":"Clinical applications of optical coherence tomography angiography: What we have learnt in the first 3 years","volume":"28","author":"Cohen","year":"2018","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1097\/IAE.0000000000000744","article-title":"Retinal and choroidal vasculature in birdshot chorioretinopathy analyzed using spectral domain optical coherence tomography angiography","volume":"35","author":"Adhi","year":"2015","journal-title":"Retina"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40942-020-00245-w","article-title":"Posterior segment inflammatory outcomes assessed using fluorescein angiography in the STOP-UVEITIS study","volume":"6","author":"Sadiq","year":"2020","journal-title":"Int. J. Retin. Vitr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40942-015-0005-8","article-title":"A review of optical coherence tomography angiography","volume":"1","author":"Waheed","year":"2015","journal-title":"Int. J. Retin. Vitr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/jamaophthalmol.2014.3616","article-title":"Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography","volume":"133","author":"Spaide","year":"2015","journal-title":"JAMA Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1136\/bjophthalmol-2020-318191","article-title":"OCTA versus dye angiography for the diagnosis and evaluation of neovascularization in punctate inner choroidopathy","volume":"106","author":"Gan","year":"2022","journal-title":"Br. J. Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/bjophthalmol-2017-311764","article-title":"Optical coherence tomography angiography in comparison with other multimodal imaging techniques in punctate inner choroidopathy","volume":"103","author":"Pohlmann","year":"2019","journal-title":"Br. J. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.survophthal.2016.10.003","article-title":"Punctate inner choroidopathy: A review","volume":"62","author":"Ahnood","year":"2017","journal-title":"Surv. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/IAE.0000000000001128","article-title":"Longitudinal Follow-up of Choroidal Granulomas Using Enhanced Depth Imaging Optical Coherence Tomography","volume":"37","author":"Invernizzi","year":"2017","journal-title":"Retina"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1097\/ICB.0000000000000422","article-title":"Why the Dots Are Black Only in the late Phase of the Indocyanine Green Angiography in Multiple Evanescent White Dot Syndrome","volume":"11","author":"Gaudric","year":"2017","journal-title":"Retin. Cases Brief Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/eye.2017.180","article-title":"Application of OCT-angiography to characterize the evolution of chorioretinal lesions in acute posterior multifocal placoid pigment epitheliopathy","volume":"31","author":"Burke","year":"2017","journal-title":"Eye"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3928\/23258160-20170829-07","article-title":"Multi-Modal Imaging Including Optical Coherence Tomography Angiography in Patients With Posterior Multifocal Placoid Pigment Epitheliopathy","volume":"48","author":"Werner","year":"2017","journal-title":"Ophthalmic Surg. Lasers Imaging Retin."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.preteyeres.2017.04.005","article-title":"The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases","volume":"59","author":"Pichi","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00417-020-04945-9","article-title":"A quantitative comparison of four optical coherence tomography angiography devices in healthy eyes","volume":"259","author":"Lu","year":"2021","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Filali Ansary, M., Crincoli, E., Semoun, O., Uzzan, J., Amoroso, F., Jung, C., Miere, A., and Souied, E. (2022). Undetectable Macular Neovascularization on OCT Angiography in Age Related Macular Degeneration: Comparison between Different Devices. Medicina, 58.","DOI":"10.3390\/medicina58091246"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1097\/IAE.0000000000002915","article-title":"Longitudinal Follow-up of Tubercular Serpiginous-Like Choroiditis Using Optical Coherence Tomography Angiography","volume":"41","author":"Agarwal","year":"2023","journal-title":"Retina"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/7\/1296\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:06:52Z","timestamp":1760123212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/7\/1296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["diagnostics13071296"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13071296","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2023,3,30]]}}}