{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:45:24Z","timestamp":1770839124086,"version":"3.50.1"},"reference-count":69,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Sciences and Technological Development of The Republic of Serbia","award":["175005"],"award-info":[{"award-number":["175005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Incontinentia pigmenti (IP) is a rare skin disease combined with anomalies of the teeth, eyes, and central nervous system (CNS). Mutations of the IKBKG gene are responsible for IP. Among the most frequent CNS abnormalities found in IP using magnetic resonance imaging (MRI) are corpus callosum (CC) abnormalities. The aim of the study was to determine the presence of CC abnormalities, their relationship with the IKBKG mutations, and the possible presence of mutations of other genes. A group of seven IP patients was examined. Analyses of the IKBKG gene and the X-chromosome inactivation pattern were performed, as well as MRI and whole exome sequencing (WES) with the focus on the genes relevant for neurodegeneration. WES analysis showed IKBKG mutation in all examined patients. A patient who had a mutation of a gene other than IKBKG was excluded from further study. Four of the seven patients had clinically diagnosed CNS anomalies; two out of four had MRI-diagnosed CC anomalies. The simultaneous presence of IKBKG mutation and CC abnormalities and the absence of other mutations indicate that IKBKG may be the cause of CC abnormalities and should be included in the list of genes responsible for CC abnormalities.<\/jats:p>","DOI":"10.3390\/diagnostics13071300","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T04:45:35Z","timestamp":1680151535000},"page":"1300","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Impact of the IKBKG Gene on the Appearance of the Corpus Callosum Abnormalities in Incontinentia Pigmenti"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2185-9749","authenticated-orcid":false,"given":"Sne\u017eana","family":"Mini\u0107","sequence":"first","affiliation":[{"name":"Clinic of Dermatovenerology, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Deligradska 34, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nata\u0161a","family":"Cerovac","sequence":"additional","affiliation":[{"name":"Clinic for Neurology and Psychiatry for Children and Youth, University Clinical Center of Serbia, Dr. Subotica 6a, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Novakovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Faculty of Medicine, University of Belgrade, Vi\u0161egradska 26, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan","family":"Gazikalovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Mother and Child Healthcare of Serbia \u201cDr Vukan \u010cupi\u0107\u201d, Radoja Daki\u0107a 8, 11070 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Popadi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Dermatovenerology, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Deligradska 34, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Du\u0161an","family":"Trpinac","sequence":"additional","affiliation":[{"name":"Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, Vi\u0161egradska 26, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"ref_1","unstructured":"(2023, January 02). Orphanet Report Series. Number 1, 2022. Prevalence of Rare Diseases. Available online: https:\/\/www.orpha.net\/orphacom\/cahiers\/docs\/GB\/Prevalence_of_rare_diseases_by_alphabetical_list.pdf."},{"key":"ref_2","unstructured":"Adam, M.P., Mirzaa, G.M., Pagon, R.A., and Wallace, S.E. (2023, January 02). Incontinentia Pigmenti, Available online: https:\/\/www.ncbi.nlh.nih.gov\/books\/NBK1472."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1136\/jmg.30.1.53","article-title":"Incontinentia pigmenti (Bloch-Sulzberger syndrome)","volume":"30","author":"Landy","year":"1993","journal-title":"J. Med. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1067\/mjd.2002.125949","article-title":"Incontinentia pigmenti: A review and update on the molecular basis of pathophysiology","volume":"47","author":"Berlin","year":"2002","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/35013114","article-title":"Genomic rearrangement in NEMO impairs NF-\u03baB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium","volume":"405","author":"Smahi","year":"2000","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Karin, M. (2011). NF-kB in Health and Disease, Springer.","DOI":"10.1007\/978-3-642-16017-2"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.1038\/sj.onc.1209939","article-title":"Mutations in the NF-\u03baB signaling pathway: Implication for human disease","volume":"25","author":"Courtois","year":"2006","journal-title":"Oncogene"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/hmg\/10.19.2171","article-title":"A recurrent deletion in the ubiquitously expressed NEMO (IKK-\u03b3) gene accounts for the vast majority of incontinentia pigmenti mutations","volume":"10","author":"Aradhya","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1750-1172-8-25","article-title":"Central nervous system anomalies in incontinentia pigmenti","volume":"8","author":"Trpinac","year":"2013","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/cge.12223","article-title":"Incontinentia pigmenti diagnostic criteria update","volume":"85","author":"Trpinac","year":"2014","journal-title":"Clin. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ejmg.2012.04.007","article-title":"Neurological findings in incontinentia pigmenti; a review","volume":"55","author":"Meuwissen","year":"2012","journal-title":"Eur. J. Med. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40748-021-00136-4","article-title":"CNS malformations in the newborn","volume":"8","author":"Burd","year":"2022","journal-title":"Matern. Health Neonatol. Perinatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ajhg.2013.02.004","article-title":"Whole-exome sequencing identifies mutated c12orf57 in recessive corpus callosum hypoplasia","volume":"92","author":"Akizu","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0072-9752(07)87005-9","article-title":"Embryology and malformations of the forebrain commissures","volume":"87","author":"Sarnat","year":"2008","journal-title":"Handb. Clin. Neurol."},{"key":"ref_15","unstructured":"Carlson, B. (2019). Human Embryology and Developmental Biology, Elsevier. [6th ed.]."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1002\/ajmg.a.33558","article-title":"Identification of genomic loci contributing to agenesis of the corpus callosum","volume":"152A","author":"Black","year":"2010","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1399-0004.2004.00354.x","article-title":"Mechanisms regulating the development of the corpus callosum and its agenesis in mouse and human","volume":"66","author":"Richards","year":"2004","journal-title":"Clin. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrn2107","article-title":"Agenesis of the corpus callosum: Genetic, developmental and functional aspects of connectivity","volume":"8","author":"Paul","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11689-010-9059-y","article-title":"Developmental malformation of the corpus callosum: A review of typical callosal development and examples of developmental disorders with callosal involvement","volume":"3","author":"Paul","year":"2011","journal-title":"J. Neurodev. Disord."},{"key":"ref_20","first-page":"7","article-title":"Absence makes the search grow longer","volume":"58","author":"Dobyns","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"ref_21","unstructured":"Gleason, C.A., and Juul, S.E. (2018). Avery\u2019s Diseases of the Newborn, Elsevier. [10th ed.]."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hofman, J., Hutny, M., Sztuba, K., and Paprocka, J. (2020). Corpus callosum agenesis: An insight into the etiology and spectrum of symptoms. Brain Sci., 10.","DOI":"10.3390\/brainsci10090625"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.pediatrneurol.2005.08.008","article-title":"Agenesis of the corpus callosum: Clinical and genetic study in 63 young patients","volume":"34","author":"Bedeschi","year":"2006","journal-title":"Pediatr. Neurol."},{"key":"ref_24","unstructured":"Volpe, J.J. (2018). VOLPE\u2019S Neurology of the Newborn, Elsevier. [6th ed.]."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/brain\/awt358","article-title":"Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes","volume":"137","author":"Edwards","year":"2014","journal-title":"Brain"},{"key":"ref_26","unstructured":"(2023, January 02). OMIM, Available online: https:\/\/www.ncbi.nlm.nih.gov\/omim\/?term=corpus+callosum."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejpn.2017.08.003","article-title":"Outcome of isolated agenesis of the corpus callosum: A population-based prospective study","volume":"22","author":"Rolland","year":"2018","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1080\/15513815.2020.1723148","article-title":"Hypoplasia of the corpus callosum: A single center experience and a concise literature review","volume":"40","author":"Boccherini","year":"2021","journal-title":"Fetal Pediatr. Pathol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ku, R.Y., and Torii, M. (2021). New molecular players in the development of callosal projections. Cells, 10.","DOI":"10.3390\/cells10010029"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Mini\u0107, S., Trpinac, D., Novakovi\u0107, I., Cerovac, N., Dobrosavljevi\u0107 Vukojevi\u0107, D., and Rosain, J. (2022). Challenges in rare diseases diagnostics: Incontinentia pigmenti with heterozygous GBA mutation. Diagnostics, 12.","DOI":"10.3390\/diagnostics12071711"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/pd.889","article-title":"A novel PCR approach for prenatal detection of the common NEMO rearrangement in incontinentia pigmenti","volume":"24","author":"Steffan","year":"2004","journal-title":"Prenat. Diagn."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/ajd.12407","article-title":"Improved molecular diagnosis of the common recurrent intragenic deletion mutation in IKBKG in a Filipino family with incontinentia pigmenti","volume":"57","author":"Guevara","year":"2016","journal-title":"Australas. J. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng1197-353","article-title":"A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation","volume":"17","author":"Plenge","year":"1997","journal-title":"Nat. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1086\/507565","article-title":"X chromosome-inactivation patterns of 1005 phenotypically unaffected females","volume":"79","author":"Cottle","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"ref_35","unstructured":"Illumina (2022, March 10). TruSight One Sequencing Panel Series. Available online: https:\/\/support.illumina.com\/downloads\/trusight_one_capture_sample_prep_guide_15046431.html."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1468-1331.2012.03817.x","article-title":"Glucocerebrosidase mutations in a Serbian Parkinson\u2019s disease population","volume":"20","author":"Kumar","year":"2013","journal-title":"Eur. J. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/cge.13848","article-title":"Diagnostic yield and clinical utility of whole exome sequencing using an automated variant prioritization system, EVIDENCE","volume":"98","author":"Seo","year":"2020","journal-title":"Clin. Genet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0387-7604(93)90122-O","article-title":"Incontinentia pigmenti: Clinical and neuroradiologic features","volume":"15","author":"Mangano","year":"1993","journal-title":"Brain Dev."},{"key":"ref_40","first-page":"555","article-title":"Imaging findings in patients with clinical anophthalmos","volume":"18","author":"Albernaz","year":"1997","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s002340050600","article-title":"Central nervous system involvement in incontinentia pigmenti: Cranial MRI of two siblings","volume":"40","author":"Midia","year":"1998","journal-title":"Neuroradiology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s004310000589","article-title":"Incontinentia pigmenti: A report of ten cases","volume":"160","author":"Lamas","year":"2001","journal-title":"Eur. J. Pediatr."},{"key":"ref_43","first-page":"1163","article-title":"Clinical study of 40 cases of incontinentia pigmenti","volume":"139","author":"Froidevaux","year":"2003","journal-title":"Arch. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"PO215","DOI":"10.1055\/s-2004-828208","article-title":"Bildgebung, DTI und Spektroskopie bei Incontinentia pigmenti (Bloch-Sulzberger-Syndrom)","volume":"176","author":"Boor","year":"2004","journal-title":"Fortschr. R\u00f6ntgenstr."},{"key":"ref_45","first-page":"239","article-title":"Incontinentia pigmenti: Clinical and neuroimaging findings in a series of 12 patients","volume":"21","author":"Martinez","year":"2006","journal-title":"Neurologia"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ejpn.2007.09.001","article-title":"Extensive cerebral infarction in the newborn due to incontinentia pigmenti","volume":"12","author":"Lequin","year":"2008","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00381-007-0550-z","article-title":"Serial changes in white matter lesions in a neonate with incontinentia pigmenti","volume":"24","author":"Lee","year":"2008","journal-title":"Childs Nerv. Syst."},{"key":"ref_48","first-page":"190","article-title":"Incontinentia pigmenti: A case report and literature review","volume":"51","author":"Emre","year":"2009","journal-title":"Turk. J. Pediatr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1177\/0883073808327835","article-title":"Recurrent stroke in a child with incontinentia pigmenti","volume":"24","author":"Cartwright","year":"2009","journal-title":"J. Child Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1177\/0883073808324774","article-title":"Incontinentia pigmenti with encephalocele in a neonate: A rare association","volume":"24","author":"Demirel","year":"2009","journal-title":"J. Child Neurol."},{"key":"ref_51","first-page":"157","article-title":"A female child with skin lesions and seizures","volume":"9","author":"Ganesh","year":"2009","journal-title":"SQU Med. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.braindev.2010.04.002","article-title":"Early infantile manifestations of incontinentia pigmenti mimicking acute encephalopathy","volume":"33","author":"Abe","year":"2011","journal-title":"Brain Dev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1651-2227.2010.01921.x","article-title":"Incontinentia pigmenti revisited. A novel nonsense mutation of the IKBKG gene","volume":"100","author":"Fryssira","year":"2011","journal-title":"Acta Paediatr."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Migeon, B.R. (2014). Females Are Mosaics: X Inactivation and Sex Differences in Disease, Oxford University Press.","DOI":"10.1093\/med\/9780199927531.001.0001"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s004390000382","article-title":"Age- and tissue-specific variation of X chromosome inactivation ratios in normal women","volume":"107","author":"Sharp","year":"2000","journal-title":"Hum. Genet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/hmg\/5.11.1777","article-title":"Selection against mutant alleles in blood leukocytes is a consistent feature in Incontinentia Pigmenti Type 2","volume":"5","author":"Parrish","year":"1996","journal-title":"Hum. Mol. Gen."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00439-005-0068-y","article-title":"A new mutation in exon 7 of NEMO gene: Late skewed X-chromosome inactivation in an incontinentia pigmenti female patient with immunodeficiency","volume":"118","author":"Martin","year":"2005","journal-title":"Hum. Genet."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ymgme.2017.07.001","article-title":"Severe neuroimaging anomalies are usually associated with random X inactivation in leucocytes circulating DNA in X-linked dominant Incontinentia Pigmenti","volume":"122","author":"Bal","year":"2017","journal-title":"Mol. Genet. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00784-012-0721-5","article-title":"Dental and oral anomalies in incontinentia pigmenti: A systematic review","volume":"17","author":"Trpinac","year":"2013","journal-title":"Clin. Oral. Investig."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Ruggieri, M., Pascual-Castroviejo, I., and di Rocco, C. (2008). Neurocutaneous Disorders. Phakomatoses & Hamartoneoplastic Syndromes, Springer.","DOI":"10.1007\/978-3-211-69500-5"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1111\/dmcn.13140","article-title":"Clinical presentation and spectrum of neuroimaging findings in newborn infants with incontinentia pigmenti","volume":"58","author":"Lichtenbelt","year":"2016","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_62","first-page":"1521","article-title":"Incontinentia pigmenti: MR demonstration of brain changes","volume":"15","author":"Roche","year":"1994","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/RMR.0000000000000185","article-title":"The Rare Neurocutaneous Disorders: Update on Clinical, Molecular, and Neuroimaging Features","volume":"27","author":"Barros","year":"2018","journal-title":"Top. Magn. Reson. Imaging"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/B978-0-444-52891-9.00040-3","article-title":"Incontinentia pigmenti and hypomelanosis of Ito","volume":"111","author":"Bodemer","year":"2013","journal-title":"Handb. Clin. Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4161\/cam.3.2.7855","article-title":"Cell lineages and early patterns of embryonic CNS vascularization","volume":"3","author":"Kurz","year":"2008","journal-title":"Cell Adh. Migr."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Rinaldi, C., Donato, L., Alibrandi, S., Scimone, C., D\u2019Angelo, R., and Sidoti, A. (2021). Oxidative Stress and the Neurovascular Unit. Life, 11.","DOI":"10.3390\/life11080767"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.pediatrneurol.2014.07.023","article-title":"Cerebrospinal fluid oxidative stress marker levels and cytokine concentrations in a neonate with incontinentia pigmenti","volume":"51","author":"Ohkawa","year":"2014","journal-title":"Pediatr. Neurol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Florian, I.S. (2020). Pineal Region Lesions, Springer.","DOI":"10.1007\/978-3-030-50913-2"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.mehy.2013.07.024","article-title":"Blaschko line analogies in the central nervous system: A hypothesis","volume":"81","author":"Trpinac","year":"2013","journal-title":"Med. Hypotheses"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/7\/1300\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:07:02Z","timestamp":1760123222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/7\/1300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":69,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["diagnostics13071300"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13071300","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,30]]}}}