{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T23:42:31Z","timestamp":1783208551953,"version":"3.54.6"},"reference-count":54,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The aim of this review is to identify a preventive strategy in order to minimize the risk of adverse events in patients with coronary syndromes and acute exposure to high-altitude. For this purpose we searched the electronic database of PubMed, EMBASE, and Web of Science for studies published in the last 30 years in this field. The conclusions of this review are: patients with stable coronary artery disease on optimal treatment and in a good physical condition can tolerate traveling to high altitude up to 3500 m; on the other hand, patients with unstable angina or recent myocardial infarction no older than 6 months should take less interest in hiking or any activity involving high altitude. Air-traveling is contraindicated for patients with myocardial infarction within previous 2 weeks, angioplasty or intracoronary stent placement within previous 2 weeks, and unstable angina or coronary artery bypass grafting within previous 3 weeks. The main trigger for sudden cardiac death is the lack of gradual acclimatization to high-altitude and to the exercise activity, and the most important risk factor is prior myocardial infarction.<\/jats:p>","DOI":"10.3390\/diagnostics13071317","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T01:37:05Z","timestamp":1680485825000},"page":"1317","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Coronary Syndromes and High-Altitude Exposure\u2014A Comprehensive Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Liviu","family":"Macovei","sequence":"first","affiliation":[{"name":"Acute Cardiac Care Unit, Cardiology Clinic, Institute of Cardiovascular Diseases \u201cProf. Dr. George I.M. Georgescu\u201d, \u201cGrigore T Popa\u201d University of Medicine and Pharmacy, 700503 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Mirela","family":"Macovei","sequence":"additional","affiliation":[{"name":"Pneumology Clinic, Pneumology Hospital, Dr. I Cihac No. 30 Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragos Cristian","family":"Macovei","sequence":"additional","affiliation":[{"name":"Faculty of Economics and Business Administration, \u201cAlexandru I Cuza\u201d University, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Miko\u0142ajczak, K., Czerwi\u0144ska, K., Pilecki, W., Por\u0119ba, R., Ga\u0107, P., and Por\u0119ba, M. (2021). The Impact of Temporary Stay at High Altitude on the Circulatory System. J. Clin. 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