{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:48:08Z","timestamp":1790092088937,"version":"4.0.1"},"reference-count":12,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences","award":["CIFMS 2022-I2M-JB-001"],"award-info":[{"award-number":["CIFMS 2022-I2M-JB-001"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["82071967"],"award-info":[{"award-number":["82071967"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2022-PUMCH-D-002"],"award-info":[{"award-number":["2022-PUMCH-D-002"]}]},{"name":"National Natural Science Foundation of China","award":["CIFMS 2022-I2M-JB-001"],"award-info":[{"award-number":["CIFMS 2022-I2M-JB-001"]}]},{"name":"National Natural Science Foundation of China","award":["82071967"],"award-info":[{"award-number":["82071967"]}]},{"name":"National Natural Science Foundation of China","award":["2022-PUMCH-D-002"],"award-info":[{"award-number":["2022-PUMCH-D-002"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["CIFMS 2022-I2M-JB-001"],"award-info":[{"award-number":["CIFMS 2022-I2M-JB-001"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["82071967"],"award-info":[{"award-number":["82071967"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-D-002"],"award-info":[{"award-number":["2022-PUMCH-D-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>A 47-year-old female with cardiac dysfunction and lymphadenopathy underwent 18FDG PET\/CT and 68Ga-FAPI-04 imaging for tumor screening. Mild uptake in the left ventricular wall was detected on the oncology 18FDG PET\/CT. True myocardiac-involvement could not be distinguished with physiological uptake. The following 68Ga-FAPI-04 showed intense heterogeneous uptake in the left ventricular wall, particularly in the septum and apex area, corresponding with the late gadolinium enhancement regions shown by cardiac MR. Intense uptake was also noted in the mediastinal and bilateral hilar lymph nodes. Endomyocardial biopsy demonstrated sarcoidosis.<\/jats:p>","DOI":"10.3390\/diagnostics13081450","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T01:36:45Z","timestamp":1681781805000},"page":"1450","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["In Vivo Fibroblast Activation of Systemic Sarcoidosis: A 68Ga-FAPI-04 PET\/CT Imaging Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Jingnan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China"},{"name":"Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China"},{"name":"Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3261-6569","authenticated-orcid":false,"given":"Lu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China"},{"name":"Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-6233","authenticated-orcid":false,"given":"Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1010 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tana, C. (2021). Sarcoidosis: An Old but Always Challenging Disease. Diagnostics, 11.","DOI":"10.3390\/diagnostics11040696"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ruaro, B., Confalonieri, P., Santagiuliana, M., Wade, B., Baratella, E., Kodric, M., Berria, M., Jaber, M., Torregiani, C., and Bruni, C. (2021). Correlation between Potential Risk Factors and Pulmonary Embolism in Sarcoidosis Patients Timely Treated. J. Clin. Med., 10.","DOI":"10.3390\/jcm10112462"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0002-8703(99)70115-8","article-title":"Histologic Diagnostic Rate of Cardiac Sarcoidosis: Evaluation of Endomyocardial Biopsies","volume":"138","author":"Uemura","year":"1999","journal-title":"Am. Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Dendl, K., Koerber, S.A., Kratochwil, C., Cardinale, J., Finck, R., Dabir, M., Novruzov, E., Watabe, T., Kramer, V., and Choyke, P.L. (2021). FAP and FAPI-PET\/CT in Malignant and Non-Malignant Diseases: A Perfect Symbiosis?. Cancers, 13.","DOI":"10.3390\/cancers13194946"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.jacc.2021.02.019","article-title":"Molecular Imaging Identifies Fibroblast Activation Beyond the Infarct Region After Acute Myocardial Infarction","volume":"77","author":"Diekmann","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1097\/RLU.0000000000003334","article-title":"68Ga-FAPI-04 Accumulation in Myocardial Infarction in a Patient with Neuroendocrine Carcinoma","volume":"45","author":"Zhu","year":"2020","journal-title":"Clin. Nucl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/RLU.0000000000003745","article-title":"Visualization of Fibroblast Activation After Myocardial Infarction Using 68Ga-FAPI PET","volume":"46","author":"Kessler","year":"2021","journal-title":"Clin. Nucl. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s12350-020-02315-w","article-title":"Cardiac Fibroblast Activation in Dilated Cardiomyopathy Detected by Positron Emission Tomography","volume":"29","author":"Shi","year":"2022","journal-title":"J. Nucl. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1007\/s12350-021-02646-2","article-title":"Diffuse Uptake of [(68)Ga]Ga-FAPI in the Left Heart in a Patient with Hypertensive Heart Disease by PET\/CT","volume":"29","author":"Lin","year":"2021","journal-title":"J. Nucl. 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Case Rep."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/8\/1450\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:17:42Z","timestamp":1760123862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/13\/8\/1450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":12,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["diagnostics13081450"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics13081450","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]}}}