{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T09:40:06Z","timestamp":1763545206402,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Northeastern Society of Orthodontics Resident Research Program Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>In children born with cleft lip and palate, the timing of the secondary alveolar bone graft (SABG) is crucial to its success; this involves estimating the eruption of the permanent maxillary canine. Altered dental eruption in this patient group gives impetus to the identification of dental developmental factors concerning maxillary canine eruption, which may steer the clinical decision of SABG timing. Records of over nine hundred patients who received SABG with pre- and post-operative cone beam computed tomography (CBCT) scans were analyzed for inclusion and divided into two groups (erupting or non-erupting canine after SABG). Roots of the maxillary canines and premolars were segmented from the cementoenamel junction then linear and volumetric measurements were performed. The pre- and post-operative root length and volume differences were calculated and compared statistically using independent sample tests and paired t-tests. No statistically significant differences were found in the volume change (%), or reciprocal of mean root length in the erupted and unerupted groups in the canine, first premolar, or second premolar roots except for an association between the post-operative dental root length of the canine and the maxillary canine eruption status. Therefore, assessment of root development from pre-treatment CBCT scans was not deemed worthy from a diagnostic perspective.<\/jats:p>","DOI":"10.3390\/diagnostics13091642","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T01:32:53Z","timestamp":1683509573000},"page":"1642","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Dental Root Development Regarding Maxillary Canine Eruption Status after Secondary Alveolar Bone Grafting in Patients with Cleft Lip and Palate"],"prefix":"10.3390","volume":"13","author":[{"given":"Melissa A.","family":"Ferguson","sequence":"first","affiliation":[{"name":"Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sercan","family":"Akyalcin","sequence":"additional","affiliation":[{"name":"Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Campos","sequence":"additional","affiliation":[{"name":"Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Gliksten","sequence":"additional","affiliation":[{"name":"Evidence-Based Health Care Program, University of Oxford, Oxford OX1 3PJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadriye","family":"Hargett","sequence":"additional","affiliation":[{"name":"Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Yang","sequence":"additional","affiliation":[{"name":"Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"MacLaine","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Boston Children\u2019s Hospital, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1597\/08-171","article-title":"Three-dimensional assessment of the eruption path of the canine in individuals with bone-grafted alveolar clefts using cone beam computed tomography","volume":"47","author":"Oberoi","year":"2010","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jormas.2021.05.008","article-title":"Global prevalence of cleft palate, cleft lip and cleft palate and lip: A comprehensive systematic review and meta-analysis","volume":"123","author":"Salari","year":"2022","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Paradowska-Stolarz, A., Mikulewicz, M., and Dus-Ilnicka, I. (2022). Current Concepts and Challenges in the Treatment of Cleft Lip and Palate Patients-A Comprehensive Review. J. Pers. Med., 12.","DOI":"10.3390\/jpm12122089"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.joms.2018.11.019","article-title":"Optimal Timing of Secondary Alveolar Bone Grafting: A Literature Review","volume":"77","author":"Fahradyan","year":"2019","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1097\/PRS.0000000000002778","article-title":"Alveolar Bone Grafting and Cleft Lip and Palate: A Review","volume":"138","author":"Weissler","year":"2016","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1051\/orthodfr\/2017011","article-title":"Timing of alveolar bone graft and sequences of canine eruption in cases of cleft lip and palate: A systematic review","volume":"88","author":"Elhaddaoui","year":"2017","journal-title":"Orthod Fr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1097\/SCS.0000000000004680","article-title":"Optimal Timing of Alveolar Cleft Bone Grafting for Maxillary Clefts in the Cleft Palate Population","volume":"29","author":"Kaura","year":"2018","journal-title":"J. Craniofac. Surg."},{"key":"ref_8","first-page":"87","article-title":"Secondary bone grafting of residual alveolar and palatal clefts","volume":"30","author":"Boyne","year":"1972","journal-title":"J. Oral Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.dental.2010.10.017","article-title":"Deproteinized bovine bone in periodontal and implant surgery","volume":"27","author":"Baldini","year":"2011","journal-title":"Dent. Mater."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Petretta, M., Gambardella, A., Boi, M., Berni, M., Cavallo, C., Marchiori, G., Maltarello, M.C., Bellucci, D., Fini, M., and Baldini, N. (2021). Composite Scaffolds for Bone Tissue Regeneration Based on PCL and Mg-Containing Bioactive Glasses. Biology, 10.","DOI":"10.3390\/biology10050398"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chisci, G., Hatia, A., Chisci, E., Chisci, D., Gennaro, P., and Gabriele, G. (2023). Socket Preservation after Tooth Extraction: Particulate Autologous Bone vs. Deproteinized Bovine Bone. Bioengineering, 10.","DOI":"10.3390\/bioengineering10040421"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1177\/1055665621995047","article-title":"Long-Term Treatment Outcomes of Primary Alveolar Bone Grafts for Alveolar Clefts: A Qualitative Systematic Review","volume":"59","author":"Carbullido","year":"2022","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.sdentj.2015.01.006","article-title":"Is alveolar cleft reconstruction still controversial? (Review of literature)","volume":"28","author":"Seifeldin","year":"2016","journal-title":"Saudi Dent. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0889-5406(87)90417-3","article-title":"Effect of timing on long-term clinical success of alveolar cleft bone grafts","volume":"92","author":"Helms","year":"1987","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0002-9416(84)90376-2","article-title":"Delayed bone grafting in the cleft maxilla and palate: A retrospective multidisciplinary analysis","volume":"86","author":"Turvey","year":"1984","journal-title":"Am. J. Orthod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0002-9416(76)90258-X","article-title":"Combined orthodontic-surgical management of residual palato-alveolar cleft defects","volume":"70","author":"Boyne","year":"1976","journal-title":"Am. J. Orthod."},{"key":"ref_17","first-page":"721","article-title":"Alveolar bone grafts: The surgical\/orthodontic management of the cleft maxilla","volume":"28","author":"Vig","year":"1999","journal-title":"Ann. Acad. Med. Singap."},{"key":"ref_18","first-page":"175","article-title":"Elimination of the residual alveolar cleft by secondary bone grafting and subsequent orthodontic treatment","volume":"23","author":"Bergland","year":"1986","journal-title":"Cleft Palate J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.7181\/acfs.2022.00115","article-title":"Secondary bone grafting for alveolar clefts: Surgical timing, graft materials, and evaluation methods","volume":"23","author":"Kim","year":"2022","journal-title":"Arch. Craniofac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1177\/10556656211007692","article-title":"Cleft Alveolar Bone Graft Materials: Literature Review","volume":"59","author":"Dissaux","year":"2022","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0278-2391(91)90172-I","article-title":"Retrospective analysis of 135 secondary alveolar cleft grafts using iliac or calvarial bone","volume":"49","author":"Kortebein","year":"1991","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1016\/j.joms.2021.06.021","article-title":"Observing the Eruption of Canine after Secondary Alveolar Bone Grafting","volume":"79","author":"Desai","year":"2021","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0889-5406(86)90022-3","article-title":"A review of tooth formation in children with cleft lip\/palate","volume":"90","author":"Ranta","year":"1986","journal-title":"Am. J. Orthod Dentofacial. Orthop."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.forsciint.2019.04.011","article-title":"Dental development in cleft lip and palate patients: A systematic review","volume":"300","author":"Willems","year":"2019","journal-title":"Forensic Sci. Int."},{"key":"ref_25","unstructured":"Black, G.V. (1902). Anatomy of the Human Teeth, The S.S. White Dental Manufacturing Co."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1002\/sim.7263","article-title":"Analysis of small sample size studies using nonparametric bootstrap test with pooled resampling method","volume":"36","author":"Dwivedi","year":"2017","journal-title":"Stat. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.joms.2021.12.004","article-title":"Cone Beam Computed Tomographic Analysis Demonstrates a 94% Radiographic Success Rate in 783 Alveolar Bone Grafts","volume":"80","author":"Padwa","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_28","first-page":"335","article-title":"Confidence interval or p-value?: Part 4 of a series on evaluation of scientific publications","volume":"106","author":"Hommel","year":"2009","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.compbiomed.2016.01.018","article-title":"A new computational method for automatic dental measurement: The case of maxillary central incisor","volume":"70","author":"Bernardi","year":"2016","journal-title":"Comput. Biol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Haberthur, D., Hlushchuk, R., and Wolf, T.G. (2021). Automated segmentation and description of the internal morphology of human permanent teeth by means of micro-CT. BMC Oral Health, 21.","DOI":"10.1186\/s12903-021-01551-x"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kuralt, M., Cmok Ku\u010di\u010d, A., Ga\u0161per\u0161i\u010d, R., Gro\u0161elj, J., Knez, M., and Fidler, A. (2022). Gingival shape analysis using surface curvature estimation of the intraoral scans. 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