{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:33:50Z","timestamp":1776929630463,"version":"3.51.2"},"reference-count":43,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and intolerance to cyclooxygenase-1 inhibitors. Interest is emerging in studying the role of circulating inflammatory cells in CRSwNP pathogenesis and its course, as well as their potential use for a patient-tailored approach. By releasing IL-4, basophils play a crucial role in activating the Th2-mediated response. The main aim of this study was to, first, investigate the level of the pre-operative blood basophils\u2019 values, blood basophil\/lymphocyte ratio (bBLR) and blood eosinophil-to-basophil ratio (bEBR) as predictors of recurrent polyps after endoscopic sinus surgery (ESS) in AERD patients. The secondary aim was to compare the blood basophil-related variables of the AERD series (study group) with those of a control group of 95 consecutive cases of histologically non-eosinophilic CRSwNP. The AERD group showed a higher recurrence rate than the control group (p &lt; 0.0001). The pre-operative blood basophil count and pre-operative bEBR were higher in AERD patients than in the control group (p = 0.0364 and p = 0.0006, respectively). The results of this study support the hypothesis that polyps removal may contribute to reducing the inflammation and activation of basophils.<\/jats:p>","DOI":"10.3390\/diagnostics13111920","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T04:40:51Z","timestamp":1685508051000},"page":"1920","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease"],"prefix":"10.3390","volume":"13","author":[{"given":"Giuseppe","family":"Brescia","sequence":"first","affiliation":[{"name":"ENT Unit, Department of Surgery, Ospedali Riuniti Padova Sud, 35043 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-9802","authenticated-orcid":false,"given":"Cristoforo","family":"Fabbris","sequence":"additional","affiliation":[{"name":"ENT Unit, Department of Surgery, Ospedali Riuniti Padova Sud, 35043 Padova, Italy"},{"name":"Department of Medicine DIMED, Padova University, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Calvanese","sequence":"additional","affiliation":[{"name":"ENT Unit, Department of Surgery, Ospedali Riuniti Padova Sud, 35043 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigia","family":"Bandolin","sequence":"additional","affiliation":[{"name":"ENT Unit, Department of Surgery, Ospedali Riuniti Padova Sud, 35043 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Pedruzzi","sequence":"additional","affiliation":[{"name":"ENT Unit, Department of Surgery, Ospedali Riuniti Padova Sud, 35043 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio Maria","family":"Di Pasquale Fiasca","sequence":"additional","affiliation":[{"name":"Department of Neuroscience DNS, Section of Otolaryngology, Padova University, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7623-6963","authenticated-orcid":false,"given":"Silvia","family":"Marciani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience DNS, Section of Otolaryngology, Padova University, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Mularoni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience DNS, Section of Otolaryngology, Padova University, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Degli Esposti Pallotti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience DNS, Section of Otolaryngology, Padova University, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Negrisolo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience DNS, Padova University, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Spinato","sequence":"additional","affiliation":[{"name":"Department of Neuroscience DNS, Section of Otolaryngology, Padova University, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9705-4459","authenticated-orcid":false,"given":"Anna Chiara","family":"Frigo","sequence":"additional","affiliation":[{"name":"Department of Cardiac-Thoracic-Vascular Sciences and Public Health, Padova University, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8751-0588","authenticated-orcid":false,"given":"Gino","family":"Marioni","sequence":"additional","affiliation":[{"name":"Phoniatrics and Audiology Unit, Department of Neuroscience DNS, Padova University, 31100 Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jaci.2014.08.020","article-title":"Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature","volume":"135","author":"Rajan","year":"2015","journal-title":"J. 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