{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:38:46Z","timestamp":1787027926910,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Carol Davila"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>We present the case of a 54-year-old male, without any significant medical history, who insidiously developed speech disturbances and walking difficulties, accompanied by backward falls. The symptoms progressively worsened over time. The patient was initially diagnosed with Parkinson\u2019s disease; however, he failed to respond to standard therapy with Levodopa. He came to our attention for worsening postural instability and binocular diplopia. A neurological exam was highly suggestive of a Parkinson-plus disease, most likely progressive supranuclear gaze palsy. Brain MRI was performed and revealed moderate midbrain atrophy with the characteristic \u201chummingbird\u201d and \u201cMickey mouse\u201d signs. An increased MR parkinsonism index was also noted. Based on all clinical and paraclinical data, a diagnosis of probable progressive supranuclear palsy was established. We review the main imaging features of this disease and their current role in diagnosis.<\/jats:p>","DOI":"10.3390\/diagnostics13111967","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T04:01:47Z","timestamp":1685937707000},"page":"1967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory?"],"prefix":"10.3390","volume":"13","author":[{"given":"Nicoleta","family":"Lupascu","sequence":"first","affiliation":[{"name":"Department of Neurology, \u201cDr. Carol Davila\u201d Central Military Emergency University Hospital, 010242 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioan Cristian","family":"Lupescu","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Department, University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest, 050474 Bucharest, Romania"},{"name":"Department of Neurology, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionu\u021b","family":"Caloianu","sequence":"additional","affiliation":[{"name":"Department of Neurology, \u201cDr. Carol Davila\u201d Central Military Emergency University Hospital, 010242 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin","family":"Naftanaila","sequence":"additional","affiliation":[{"name":"Radiology and Medical Imaging Department, \u201cDr. Carol Davila\u201d Central Military Emergency University Hospital, 010242 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remus Relu","family":"Glogojeanu","sequence":"additional","affiliation":[{"name":"Department of Special Motricity and Medical Recovery, The National University of Physical Education and Sports, 060057 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-1066","authenticated-orcid":false,"given":"Carmen Adella","family":"Sirbu","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Department, University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest, 050474 Bucharest, Romania"},{"name":"Center for Cognitive Research in Neuropsychiatric Pathology (Neuropsy-Cog), Department of Neurology, Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Mitrica","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Department, University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest, 050474 Bucharest, Romania"},{"name":"Department of Neurosurgery, \u201cDr. Carol Davila\u201d Central Military Emergency University Hospital, 010242 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"ref_1","unstructured":"Allan, H.R., Martin, A.S., Joshua, P.K., and Sashank, P. 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