{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:01:18Z","timestamp":1783713678041,"version":"3.55.0"},"reference-count":56,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The choroid is the main part of the uvea, the vascular layer of the eye that lies between the retina and the sclera. The high vascular component of the choroid makes this structure susceptible to inflammation in multisystemic diseases, as well as the most common site of metastasis in the eye. Therefore, the choroid is involved in many pathological conditions, from uveitis to intraocular tumors. Differentiating between inflammatory and neoplastic lesions deforming the choroidal profile can sometimes be challenging. In addition, scleral disorders can also deform the choroidal profile. Choroidal imaging includes ophthalmic ultrasonography, indocyanine green angiography, and optical coherence tomography (OCT). Recent advances in choroidal imaging techniques, such as enhanced depth imaging optical coherence tomography (EDI-OCT) and swept-source optical coherence tomography (SS-OCT), have facilitated an in-depth analysis of the choroid. The purpose of this review article is to report on and highlight the most common OCT findings to help in the differential diagnosis between inflammatory and neoplastic lesions deforming the choroidal profile.<\/jats:p>","DOI":"10.3390\/diagnostics13121991","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T01:34:32Z","timestamp":1686188072000},"page":"1991","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Optical Coherence Tomography in Inflammatory and Neoplastic Lesions Deforming the Choroidal Profile"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-0153","authenticated-orcid":false,"given":"Elena","family":"Bolletta","sequence":"first","affiliation":[{"name":"Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1471-1914","authenticated-orcid":false,"given":"Luca","family":"De Simone","sequence":"additional","affiliation":[{"name":"Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Science \u201cLuigi Sacco\u201d, Luigi Sacco Hospital, University of Milan, 20157 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Preziosa","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Science \u201cLuigi Sacco\u201d, Luigi Sacco Hospital, University of Milan, 20157 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Mastrofilippo","sequence":"additional","affiliation":[{"name":"Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2477-5463","authenticated-orcid":false,"given":"Chantal","family":"Adani","sequence":"additional","affiliation":[{"name":"Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Gentile","sequence":"additional","affiliation":[{"name":"Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy"},{"name":"Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4147-5534","authenticated-orcid":false,"given":"Fabrizio","family":"Gozzi","sequence":"additional","affiliation":[{"name":"Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-9950","authenticated-orcid":false,"given":"Luca","family":"Cimino","sequence":"additional","affiliation":[{"name":"Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy"},{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences, with Interest in Transplants, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.survophthal.2019.04.007","article-title":"Choroidal and retinal thickness in systemic autoimmune and inflammatory diseases: A review","volume":"64","author":"Steiner","year":"2019","journal-title":"Surv. 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