{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:03:13Z","timestamp":1790240593008,"version":"4.1.0"},"reference-count":24,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Patients diagnosed with Crohn\u2019s disease are increasingly subjected to repeat colonoscopic and radiological examinations to assess the extent of the disease severity and the effects of treatment. PillcamTM Crohn\u2019s video capsule, a modified colon capsule, was developed to generate a minimally invasive mouth to rectum video of the gastrointestinal tract. The capsule provides a wide-angle panoramic mucosal view to assess inflammation, ulceration, stenosis, disease extent, and effect of treatment. This review summarizes the evidence of its utility in both adult and paediatric Crohn\u2019s disease and reviews the scoring systems used to quantify findings. The literature survey indicates that the PillcamTM Crohn\u2019s capsule offers high sensitivity and specificity for the detection of inflammatory lesions and the extent and distribution of disease, and it could be considered a reliable imaging modality in both adults and childhood with Crohn\u2019s disease.<\/jats:p>","DOI":"10.3390\/diagnostics13122032","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T01:35:30Z","timestamp":1686620130000},"page":"2032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Is Panenteric PillcamTM Crohn\u2019s Capsule Endoscopy Ready for Widespread Use? A Narrative Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2642-1367","authenticated-orcid":false,"given":"Alexandros","family":"Toskas","sequence":"first","affiliation":[{"name":"St Mark\u2019s Hospital, Watford Rd., Harrow HA1 3UJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faidon-Marios","family":"Laskaratos","sequence":"additional","affiliation":[{"name":"Digestive Diseases Centre, Queen\u2019s Hospital, Barking Havering and Redbridge University Hospitals NHS Trust, Rom Valley Way, Romford RM7 0AG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3175-5548","authenticated-orcid":false,"given":"Sergio","family":"Coda","sequence":"additional","affiliation":[{"name":"Digestive Diseases Centre, Queen\u2019s Hospital, Barking Havering and Redbridge University Hospitals NHS Trust, Rom Valley Way, Romford RM7 0AG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saswata","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Digestive Diseases Centre, Queen\u2019s Hospital, Barking Havering and Redbridge University Hospitals NHS Trust, Rom Valley Way, Romford RM7 0AG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8560-7623","authenticated-orcid":false,"given":"Owen","family":"Epstein","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, Pond St., London NW3 2QG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00535-007-2153-6","article-title":"Capsule endoscopy: Past, present, and future","volume":"43","author":"Nakamura","year":"2008","journal-title":"J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Koffas, A., Papaefthymiou, A., Laskaratos, F.-M., Kapsoritakis, A., and Epstein, O. (2022). Colon Capsule Endoscopy in the Diagnosis of Colon Polyps: Who Needs a Colonoscopy?. Diagnostics, 12.","DOI":"10.3390\/diagnostics12092093"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101798","DOI":"10.1016\/j.clinre.2021.101798","article-title":"Upper gastrointestinal video capsule endoscopy: The state of the art","volume":"46","author":"Papaefthymiou","year":"2022","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4253\/wjge.v11.i6.395","article-title":"Training in video capsule endoscopy: Current status and unmet needs","volume":"11","author":"Koffas","year":"2019","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"26317745211001983","DOI":"10.1177\/26317745211001983","article-title":"How should we do colon capsule endoscopy reading: A practical guide","volume":"14","author":"Koulaouzidis","year":"2021","journal-title":"Ther. Adv. Gastrointest. Endosc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/MEG.0000000000002200","article-title":"Clinical feasibility of panintestinal (or panenteric) capsule endoscopy: A systematic review","volume":"33","author":"Valdivia","year":"2021","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_7","first-page":"580","article-title":"Pan-enteric capsule for bleeding high-risk patients. Can we limit endoscopies?","volume":"113","author":"Ribon","year":"2021","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Tontini, G.E., Rizzello, F., Cavallaro, F., Bonitta, G., Gelli, D., Pastorelli, L., Salice, M., Vecchi, M., Gionchetti, P., and Calabrese, C. (2020). Usefulness of panoramic 344\u00b0-viewing in Crohn\u2019s disease capsule endoscopy: A proof of concept pilot study with the novel PillCam\u2122 Crohn\u2019s system. BMC Gastroenterol., 20.","DOI":"10.1186\/s12876-020-01231-0"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Na, S.-Y., and Lim, Y.-J. (2021). Capsule Endoscopy in Inflammatory Bowel Disease: When? To Whom?. Diagnostics, 11.","DOI":"10.3390\/diagnostics11122240"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1177\/2050640620913368","article-title":"A novel PillCam Crohn\u2019s capsule score (Eliakim score) for quantification of mucosal inflammation in Crohn\u2019s disease","volume":"8","author":"Eliakim","year":"2020","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"E1361","DOI":"10.1055\/a-1507-4980","article-title":"A deep learning framework for autonomous detection and classification of Crohn\u2019s disease lesions in the small bowel and colon with capsule endoscopy","volume":"9","author":"Majtner","year":"2021","journal-title":"Endosc. Int. Open"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.gie.2016.09.009","article-title":"Comparing diagnostic yield of a novel pan-enteric video capsule endoscope with ileocolonoscopy in patients with active Crohn\u2019s disease: A feasibility study","volume":"85","author":"Leighton","year":"2017","journal-title":"Gastrointest. Endosc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"E1235","DOI":"10.1055\/a-0677-170","article-title":"Evaluation of a new pan-enteric video capsule endoscopy system in patients with suspected or established inflammatory bowel disease\u2014feasibility study","volume":"6","author":"Eliakim","year":"2018","journal-title":"Endosc. Int. Open"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"E1253","DOI":"10.1055\/a-0982-2786","article-title":"Comparison of small-bowel colon capsule endoscopy system to conventional colonoscopy for the evaluation of ulcerative colitis activity","volume":"7","author":"Adler","year":"2019","journal-title":"Endosc. Int. Open"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e000365","DOI":"10.1136\/bmjgast-2019-000365","article-title":"Panenteric capsule endoscopy versus ileocolonoscopy plus magnetic resonance enterography in Crohn\u2019s disease: A multicentre, prospective study","volume":"7","author":"Bruining","year":"2020","journal-title":"BMJ Open Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/2050640620948664","article-title":"Panenteric capsule endoscopy identifies proximal small bowel disease guiding upstaging and treatment intensification in Crohn\u2019s disease: A European multicentre observational cohort study","volume":"9","author":"Tai","year":"2021","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/00365521.2021.2018491","article-title":"Assessment of endoscopic response using pan-enteric capsule endoscopy in Crohn\u2019s disease; the Sensitivity to Change (STOC) study","volume":"57","author":"Volkers","year":"2022","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/j.cgh.2018.10.015","article-title":"A Treat to Target Strategy Using Panenteric Capsule Endoscopy in Pediatric Patients with Crohn\u2019s Disease","volume":"17","author":"Oliva","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/00365521.2021.2016945","article-title":"Adherence to the bowel cleansing regimen for pan-enteric capsule endoscopy in patients with suspected Crohn\u2019s disease and factors affecting the image quality","volume":"57","author":"Brodersen","year":"2022","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jpge.2015.08.004","article-title":"Endoscopic Scores for Evaluation of Crohn\u2019s Disease Activity at Small Bowel Capsule Endoscopy: General Principles and Current Applications","volume":"23","author":"Rosa","year":"2015","journal-title":"GE\u2014Port. J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1756283X17747780","DOI":"10.1177\/1756283X17747780","article-title":"The Lewis score or the capsule endoscopy Crohn\u2019s disease activity index: Which one is better for the assessment of small bowel inflammation in established Crohn\u2019s disease?","volume":"11","author":"Yablecovitch","year":"2018","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1080\/00365521.2019.1681499","article-title":"CECDAIic\u2014A new useful tool in pan-intestinal evaluation of Crohn\u2019s disease patients in the era of mucosal healing","volume":"54","author":"Arieira","year":"2019","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1111\/jgh.16007","article-title":"The diagnostic yield of pan-enteric capsule endoscopy in inflammatory bowel disease: A systematic review and meta-analysis","volume":"37","author":"Tamilarasan","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Tziortziotis, I., Laskaratos, F.-M., and Coda, S. (2021). Role of Artificial Intelligence in Video Capsule Endoscopy. 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