{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T08:21:27Z","timestamp":1772698887597,"version":"3.50.1"},"reference-count":9,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Acute interstitial nephritis (AIN) due to helminths is a rare cause of acute kidney injury (AKI). Helminthiases often progresses insidiously, making diagnosis difficult. This was the case of a 72-year-old man, who presented with renal failure, itching and diarrhoea. Urinalysis revealed leukocyturia, microhaematuria and mild proteinuria. A full blood count revealed leucocytosis with eosinophilia. A stool parasitological examination revealed fertilised eggs of Ascaris lumbricoides. Tubulointerstitial nephropathy secondary to A. lumbricoides infection was suspected. A percutaneous renal biopsy was not performed since the patient refused the anti-platelet therapy discontinuation. Mebendazole, albendazole and prednisone therapy was administered. After worm eradiation and discharge, recovery from the parasitosis, absence of pruritus and eosinophilia, and progressive improvement of renal function were observed, strongly suggesting a causal relationship between Ascaris infection and AIN. Parasite infection should be considered in the differential diagnosis of unexplained renal failure because early diagnosis and treatment are necessary to avoid irreversible complications.<\/jats:p>","DOI":"10.3390\/diagnostics13122054","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T03:02:24Z","timestamp":1686711744000},"page":"2054","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis"],"prefix":"10.3390","volume":"13","author":[{"given":"Nazareno","family":"Carullo","sequence":"first","affiliation":[{"name":"Nephrology and Dialysis Unit, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Divenuto","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Unit, Department of Health Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0880-8955","authenticated-orcid":false,"given":"Nadia","family":"Marascio","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Unit, Department of Health Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neill James","family":"Adams","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Unit, Department of Health Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Giancotti","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Unit, Department of Health Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolino","family":"Comi","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Faga","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Bolignano","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8000-0681","authenticated-orcid":false,"given":"Giuseppe","family":"Coppolino","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Serapide","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Disease Unit, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Costa","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Disease Unit, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7631-5453","authenticated-orcid":false,"given":"Carlo","family":"Torti","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Disease Unit, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Matera","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Unit, Department of Health Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Quirino","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Unit, Department of Health Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7974-3792","authenticated-orcid":false,"given":"Michele","family":"Andreucci","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s40475-020-00221-2","article-title":"Soil-Transmitted Helminths in the USA: A Review of Five Common Parasites and Future Directions for Avenues of Enhanced Epidemiologic Inquiry","volume":"8","author":"Lynn","year":"2021","journal-title":"Curr. 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Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Turgut, F., Awad, A.S., and Abdel-Rahman, E.M. (2023). Acute Kidney Injury: Medical Causes and Pathogenesis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12010375"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/ndt\/gfs143","article-title":"Spanish Registry of Glomerulonephritis. Increased prevalence of acute tubulointerstitial nephritis","volume":"28","author":"Goicoechea","year":"2013","journal-title":"Nephrol. Dial. 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